Cellule staminali
Gli inibitori delle cellule staminali sono composti che mirano specificamente alle cellule staminali e alle loro vie di segnalazione, influenzando la loro capacità di autorinnovarsi e differenziarsi. Questi inibitori sono cruciali nella ricerca focalizzata sul controllo del comportamento delle cellule staminali, sulla comprensione dei processi di sviluppo e sullo sviluppo di terapie per malattie come il cancro, dove si ritiene che le cellule staminali svolgano un ruolo chiave. Presso CymitQuimica, offriamo una varietà di inibitori delle cellule staminali per supportare la tua ricerca in medicina rigenerativa, biologia dello sviluppo e oncologia.
Trovati 145 prodotti per "Cellule staminali".
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CJJ300
CAS:CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formula:C30H33N3Purezza:99.51%Colore e forma:SolidPeso molecolare:435.6031(Rac)-SIS3 free base
CAS:(Rac)-SIS3 free base blocks Smad3 signaling, lowering ADAMTS-5 and raising miRNA-140 in chondrocytes, suppressing TGF-β1–Smad3–driven podocyte EMT, and reducing activin A–induced MHSteC proliferatFormula:C28H27N3O3Purezza:98%Colore e forma:SolidPeso molecolare:453.5323LY2382770
LY2382770 is a human monoclonal antibody (mAb) that specifically targets TGFB1. It is utilized in the study of diabetic nephropathy.SAR-439459
SAR-439459 is a human monoclonal antibody (mAb) targeting TGFB1/TGFβ-1. It blocks TGFβ-mediated pSMAD signaling and inhibits T cell and NK cell activity. Additionally, SAR-439459 exhibits antitumor properties.PF-06952229
CAS:PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.Formula:C23H24ClFN4O3Purezza:99.73% - 99.73%Colore e forma:SolidPeso molecolare:458.913LM-41
CAS:LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Formula:C19H14FNO2Purezza:99.97%Colore e forma:SolidPeso molecolare:307.32IHMT-MST1-58
CAS:IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.Formula:C21H22N6O3SPurezza:98.31% - 99.92%Colore e forma:SolidPeso molecolare:438.503LEQ506
CAS:LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Formula:C25H32N6OPurezza:99.76%Colore e forma:White SolidPeso molecolare:432.5612SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Formula:C14H14ClFN2O2Purezza:99.94%Colore e forma:White SolidPeso molecolare:296.725TT-10
CAS:TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.Formula:C11H10FN3OS2Purezza:99.76%Colore e forma:SolidPeso molecolare:283.345MSC-4106
CAS:MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.Formula:C18H12F3N3O2Purezza:99.89%Colore e forma:SolidPeso molecolare:359.302Myristoyl tetrapeptide-12
CAS:Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formula:C32H63N7O5Purezza:98%Colore e forma:SolidPeso molecolare:625.8865TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formula:C27H32N6O2Colore e forma:SolidPeso molecolare:472.582YAP-TEAD-IN-2
CAS:YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Formula:C25H24ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:470.923,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formula:C17H14O4Purezza:98%Colore e forma:SolidPeso molecolare:282.29TP0427736
CAS:TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formula:C14H10N4S2Purezza:97.26%Colore e forma:SolidPeso molecolare:298.386DT-6
CAS:DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showingFormula:C89H130N20O29S2Purezza:98%Colore e forma:SolidPeso molecolare:2008.23MR24
CAS:MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.Formula:C26H29ClN6O3Peso molecolare:509.00SWTX-143
CAS:SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFormula:C19H18F3N3OPurezza:98%Colore e forma:SolidPeso molecolare:361.36M4K2308
CAS:M4K2308, a selective ALK2 ether-linked inhibitor, demonstrates an IC50 of 2 nM and exhibits greater specificity for ALK2 over ALK5, with an IC50 of 224 nM for ALK5. This compound holds potential for research into Diffuse Intrinsic Pontine Glioma (DIPG).Formula:C26H29N3O4Peso molecolare:447.53
