Gamma-secretasi
Gli inibitori della gamma-secretasi sono composti che prendono di mira il complesso enzimatico gamma-secretasi, coinvolto nella scissione della proteina precursore dell'amiloide (APP) per produrre peptidi beta-amiloidi. Questi peptidi possono aggregarsi per formare placche amiloidi, una caratteristica distintiva della malattia di Alzheimer. Inibendo la gamma-secretasi, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, diventando così un focus chiave nella ricerca sulla malattia di Alzheimer. Presso CymitQuimica, offriamo inibitori della gamma-secretasi per supportare la tua ricerca in biologia dell'amiloide, terapia dell'Alzheimer e malattie neurodegenerative.
Trovati 62 prodotti di "Gamma-secretasi"
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Demcizumab
CAS:<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.34 kDaCB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Formula:C15H18N2OPurezza:99.44%Colore e forma:SolidPeso molecolare:242.32Rovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.02 kDaBrontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Purezza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Colore e forma:LiquidNotch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Formula:C62H97N15O22S3Colore e forma:SolidPeso molecolare:1500.72Navicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Colore e forma:LiquidSAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Formula:C96H163N36F3O25SColore e forma:SolidPeso molecolare:2310.6CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formula:C17H19N3O2SPurezza:99%Colore e forma:SolidPeso molecolare:329.42γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Formula:C25H23F3N4O2Colore e forma:SolidPeso molecolare:468.48SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Formula:C27H28FN5O4Purezza:98%Colore e forma:SolidPeso molecolare:505.54PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Formula:C20H19ClF3NO3SColore e forma:SolidPeso molecolare:445.88PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Formula:C20H18ClFN2O3SColore e forma:SolidPeso molecolare:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Formula:C94H162N36O23SPurezza:98%Colore e forma:SolidPeso molecolare:2196.58FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFormula:C22H22ClN5O2Colore e forma:SolidPeso molecolare:423.9Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Formula:C64H98N15F3O25S3Purezza:98%Colore e forma:SolidPeso molecolare:1614.81BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formula:C26H26F6N4O3Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:556.5RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFormula:C17H14FN3O2Purezza:99.79%Colore e forma:SoildPeso molecolare:311.315β-Cholanic acid
CAS:<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formula:C24H40O2Purezza:98.91% - 99.89%Colore e forma:SoildPeso molecolare:360.57Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Purezza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Colore e forma:LiquidLegumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Formula:C23H25N5O4SPurezza:98.14%Colore e forma:SolidPeso molecolare:467.54γ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formula:C24H23FN4OSPurezza:98%Colore e forma:SolidPeso molecolare:434.53FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formula:C25H30N2O5Purezza:99.81% - ≥98%Colore e forma:SolidPeso molecolare:438.52IMR-1A
CAS:IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C13H11NO5S2Purezza:97.1% - 99.76%Colore e forma:SolidPeso molecolare:325.36JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Formula:C23H24N2O3Purezza:99.61%Colore e forma:SolidPeso molecolare:376.45IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C15H15NO5S2Purezza:97.96% - 98.38%Colore e forma:SolidPeso molecolare:353.41γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Formula:C24H25ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:453MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formula:C21H21ClF2NaO4SColore e forma:SolidPeso molecolare:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purezza:97.07%Colore e forma:SolidPeso molecolare:409.48RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formula:C25H28F3N7Purezza:99.50%Colore e forma:SolidPeso molecolare:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Formula:C20H14D3FO2SColore e forma:SolidPeso molecolare:343.43Dilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Purezza:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Colore e forma:LiquidTarextumab
CAS:<p>Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.</p>Purezza:95%Colore e forma:LiquidTarlatamab
CAS:"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."Colore e forma:LiquidAβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Formula:C29H26N4O2Purezza:98%Colore e forma:SolidPeso molecolare:462.54γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formula:C24H24N4OSPurezza:99.75% - 99.96%Colore e forma:SolidPeso molecolare:416.54ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formula:C19H20BrClN2O3SPurezza:99.69%Colore e forma:SolidPeso molecolare:471.8γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Formula:C23H19FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:402.42tCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Formula:C24H44O2Purezza:98%Colore e forma:SolidPeso molecolare:364.61γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Formula:C25H22F4N6O2Purezza:98%Colore e forma:SolidPeso molecolare:514.47LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Formula:C26H23F2N3O4Purezza:98%Colore e forma:SolidPeso molecolare:479.48ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Formula:C19H20BrClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Formula:C22H29N5O8Purezza:98.80%Colore e forma:SolidPeso molecolare:491.49RR-11a
CAS:<p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>Formula:C24H28N6O10Purezza:98%Colore e forma:SolidPeso molecolare:560.51CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFormula:C17H20ClN3O2SPurezza:99.02%Colore e forma:SolidPeso molecolare:365.88BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Formula:C23H23FN6OColore e forma:SolidPeso molecolare:418.47γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFormula:C28H22F2N4O2Colore e forma:SolidPeso molecolare:484.5Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Formula:C24H24N4O2Colore e forma:SolidPeso molecolare:400.47Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formula:C24H26N6O2Purezza:98.09% - 99.87%Colore e forma:SolidPeso molecolare:430.5JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formula:C22H24N2O3Purezza:≥98% - ≥98.0%Colore e forma:SolidPeso molecolare:364.44BT-GSI
BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.Formula:C26H46BrN5O10P2Colore e forma:SolidPeso molecolare:730.52
