Recettore del fattore di crescita dei fibroblasti (FGFR)
Gli inibitori dei recettori del fattore di crescita dei fibroblasti (FGFR) sono terapie mirate che bloccano l'attività dei FGFR, coinvolti nella proliferazione cellulare, differenziazione e angiogenesi. La segnalazione FGFR contribuisce alla formazione di nuovi vasi sanguigni nei tumori, promuovendo la loro crescita e sopravvivenza. Inibire i FGFR può quindi ridurre l'angiogenesi e la progressione del tumore. Presso CymitQuimica, offriamo una gamma di inibitori FGFR di alta qualità per supportare la tua ricerca in oncologia, biologia dello sviluppo e angiogenesi.
Trovati 183 prodotti di "Recettore del fattore di crescita dei fibroblasti (FGFR)"
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FGFR4-IN-19
FGFR4-IN-19 (compound 8B) is a potent covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) with an IC50 value of 1.2 nM. It achieves high efficiency and selectivity by covalently targeting the rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 is applicable for hepatocellular carcinoma (HCC) research.Formula:C21H14Cl3N5O4Peso molecolare:505.01114BR-cpd7
BR-cpd7 is a PROTAC degrader of fibroblast growth factor receptors (FGFR1/2) with a DC50 of 10 nM. It is capable of arresting the cell cycle and inhibiting the proliferation of tumor cells with aberrant activation of FGFR1/2.Formula:C44H47Cl2N11O8Peso molecolare:927.29861Recifercept
CAS:Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for ligands of mutant FGFR3.Purezza:98.8% (SDS-PAGE); 98.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 98.4% (SEC-HPLC)Colore e forma:LiquidPNU-145156E (FCE26644)
CAS:PNU-145156E, an angiogenesis blocker with anti-tumor effects in mice, inhibits growth factors in animal studies.Formula:C45H36N10Na4O17S4Purezza:96.15%Colore e forma:SolidPeso molecolare:1209.04U3-1784
U3-1784 is a humanized monoclonal antibody targeting CD334, with anti-cancer activity, used in liver cancer research.Colore e forma:LiquidPeso molecolare:143.22 kDaFGFR4-IN-14
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutantFormula:C27H25Cl2N5O2Purezza:98%Colore e forma:SolidPeso molecolare:522.43PD 173074
CAS:Formula:C28H41N7O3Purezza:>95.0%(HPLC)Colore e forma:White to Yellow to Orange powder to crystalPeso molecolare:523.68Nintedanib
CAS:Formula:C31H33N5O4Purezza:>95.0%(T)(HPLC)Colore e forma:White to Yellow to Yellow green powder to crystalPeso molecolare:539.64Regorafenib
CAS:Formula:C21H15ClF4N4O3Purezza:>98.0%(HPLC)Colore e forma:White to Light yellow to Light orange powder to crystalPeso molecolare:482.82NSC 12
CAS:NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.Formula:C24H34F6O3Purezza:99.51%Colore e forma:SolidPeso molecolare:484.52SM27
CAS:SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.Formula:C21H16N2O9S2Purezza:98.83%Colore e forma:SolidPeso molecolare:504.49PD-161570
CAS:Formula:C26H35Cl2N7OPurezza:>98.0%(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:532.51(Z)-Orantinib
CAS:(Z)-Orantinib ((Z)-SU6668) is an orally active ATP-competitive inhibitor of Flk-1/KDR, PDGFRβ, and FGFR1, acting as a potent anti-angiogenic and anti-tumor agent.Formula:C18H18N2O3Purezza:98.05%Colore e forma:SolidPeso molecolare:310.35FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Formula:C34H36Cl2N8O4Purezza:97.63% - 98.92%Colore e forma:SolidPeso molecolare:691.61Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formula:C28H30N6OSPurezza:97.56% - >99.99%Colore e forma:SolidPeso molecolare:498.64S49076 HCl
CAS:<p>S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.</p>Formula:C22H18ClN3O5Purezza:98%Colore e forma:SolidPeso molecolare:439.85Dovitinib lactate
CAS:Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).Formula:C24H27FN6O4Purezza:99.54% - 99.77%Colore e forma:SolidPeso molecolare:482.51Ref: TM-T7104
5mg51,00€10mg79,00€25mg129,00€50mg213,00€100mg358,00€200mg535,00€500mg843,00€1mL*10mM (DMSO)57,00€R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Formula:C18H14ClFN4OPurezza:98.422%Colore e forma:SolidPeso molecolare:356.78Ref: TM-TQ0317
1mg42,00€2mg55,00€5mg88,00€10mg137,00€25mg279,00€50mg445,00€100mg677,00€1mL*10mM (DMSO)87,00€PRN1371
CAS:PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Formula:C26H30Cl2N6O4Purezza:98.65%Colore e forma:SolidPeso molecolare:561.46Ref: TM-TQ0015
1mg81,00€2mg105,00€5mg170,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)212,00€KHS 101
CAS:<p>KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.</p>Formula:C18H21N5SPurezza:99.63%Colore e forma:SolidPeso molecolare:339.46
