Recettore del fattore di crescita dei fibroblasti (FGFR)
Gli inibitori dei recettori del fattore di crescita dei fibroblasti (FGFR) sono terapie mirate che bloccano l'attività dei FGFR, coinvolti nella proliferazione cellulare, differenziazione e angiogenesi. La segnalazione FGFR contribuisce alla formazione di nuovi vasi sanguigni nei tumori, promuovendo la loro crescita e sopravvivenza. Inibire i FGFR può quindi ridurre l'angiogenesi e la progressione del tumore. Presso CymitQuimica, offriamo una gamma di inibitori FGFR di alta qualità per supportare la tua ricerca in oncologia, biologia dello sviluppo e angiogenesi.
Trovati 182 prodotti di "Recettore del fattore di crescita dei fibroblasti (FGFR)"
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Zoligratinib
CAS:Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Formula:C20H16N6OPurezza:95.28% - 99.51%Colore e forma:SolidPeso molecolare:356.38SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Formula:C17H16N2O3Purezza:98.91% - 99.64%Colore e forma:Yellow-Green SolidPeso molecolare:296.32Futibatinib
CAS:Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.Formula:C22H22N6O3Purezza:97.66% - 99.44%Colore e forma:SolidPeso molecolare:418.45Ref: TM-T5044
1mg50,00€5mg114,00€10mg167,00€25mg313,00€50mg485,00€100mg627,00€200mg890,00€1mL*10mM (DMSO)127,00€Infigratinib
CAS:<p>Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and</p>Formula:C26H31Cl2N7O3Purezza:98% - 98.97%Colore e forma:SolidPeso molecolare:560.48Ref: TM-T1975
5mg47,00€10mg60,00€25mg88,00€50mg96,00€100mg153,00€200mg274,00€500mg460,00€1mL*10mM (DMSO)50,00€R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Formula:C18H14ClFN4OPurezza:98.422%Colore e forma:SolidPeso molecolare:356.78Ref: TM-TQ0317
1mg42,00€2mg55,00€5mg88,00€10mg137,00€25mg279,00€50mg445,00€100mg677,00€1mL*10mM (DMSO)87,00€SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purezza:99.36%Colore e forma:SolidPeso molecolare:451.6Orantinib
CAS:Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Formula:C18H18N2O3Purezza:98.92% - 99.52%Colore e forma:SolidPeso molecolare:310.35CHIR-98014
CAS:<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Formula:C20H17Cl2N9O2Purezza:97.25% - 99.59%Colore e forma:SolidPeso molecolare:486.31DGY-06-116
CAS:DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.Formula:C32H33ClN8O2Purezza:97.65%Colore e forma:SolidPeso molecolare:597.11Ref: TM-T22306
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)70,00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purezza:97.58% - 99.94%Colore e forma:SolidPeso molecolare:419.48PD173074
CAS:PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.Formula:C28H41N7O3Purezza:98.15% - 98.21%Colore e forma:Yellow SolidPeso molecolare:523.67Ref: TM-T2642
5mg40,00€10mg54,00€25mg94,00€50mg133,00€100mg210,00€200mg371,00€500mg620,00€1mL*10mM (DMSO)56,00€FGFR2-IN-3
CAS:<p>FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].</p>Formula:C28H24FN7O2Purezza:99.63%Colore e forma:SoildPeso molecolare:509.53TG 100801
CAS:TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).Formula:C33H30ClN5O3Purezza:99.28% - 99.61%Colore e forma:SolidPeso molecolare:580.08Aminoquinuride
CAS:Surfen, or Aminoquinuride, reduces inflammation but blocks remyelination in MS mouse models and regulates murine T cell activation.Formula:C21H20N6OColore e forma:SolidPeso molecolare:372.42FGFR2-IN-2
CAS:FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Formula:C23H22N4OPurezza:98.09%Colore e forma:SolidPeso molecolare:370.45FGFR3-IN-2
CAS:FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).Formula:C28H39N9O4SColore e forma:SolidPeso molecolare:597.73ARQ 069
CAS:ARQ 069 inhibits FGFR2 phosphorylation concentration-dependently (IC50: 9.7 µM), without affecting β-actin. Preferentially binds inactive FGFR1/2.Formula:C18H15N3Purezza:98%Colore e forma:SolidPeso molecolare:273.33MAX-40279 hemifumarate
CAS:MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.Formula:C48H50F2N12O6S2Colore e forma:SolidPeso molecolare:993.12TG 100801 Hydrochloride
CAS:TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.Formula:C33H31Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:616.54SSR128129E free acid
CAS:SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Formula:C18H16N2O4Purezza:98%Colore e forma:SolidPeso molecolare:324.33
