ALK
Gli inibitori di ALK sono composti che mirano specificamente e inibiscono la chinasi del linfoma anaplastico (ALK), una tirosina chinasi recettoriale coinvolta nello sviluppo e nella progressione di alcuni tipi di cancro, inclusi il carcinoma polmonare non a piccole cellule e il neuroblastoma. Inibendo ALK, questi composti bloccano le vie di segnalazione che promuovono la crescita e la sopravvivenza delle cellule tumorali. Presso CymitQuimica, offriamo inibitori di ALK per supportare la tua ricerca in oncologia, terapie mirate contro il cancro e trasduzione del segnale.
Trovati 146 prodotti per "ALK".
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F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Formula:C22H27ClN8O3SPurezza:97.66%Colore e forma:SolidPeso molecolare:519.02LDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Formula:C25H24Cl2N6Purezza:99.87%Colore e forma:SolidPeso molecolare:479.4Ref: TM-T35348
5mg70,00€1mL*10mM (DMSO)74,00€10mg90,00€25mg138,00€50mg213,00€100mg318,00€500mg753,00€ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formula:C23H28ClN7O3SPurezza:98.32%Colore e forma:SolidPeso molecolare:518.03Ref: TM-T13416
1mg96,00€5mg219,00€1mL*10mM (DMSO)250,00€10mg344,00€25mg587,00€50mg803,00€100mg1.063,00€200mg1.431,00€MS4078
CAS:MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Formula:C45H52ClN9O8SPurezza:98.74%Colore e forma:Yellow SolidPeso molecolare:914.47Ref: TM-T16153
1mg49,00€2mg66,00€5mg90,00€10mg152,00€1mL*10mM (DMSO)152,00€25mg260,00€50mg416,00€100mg615,00€Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Purezza:SDS-PAGE:95% SEC-HPLC:98.18%Colore e forma:Transparent LiquidPeso molecolare:150 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurezza:98.27%Colore e forma:White SolidPeso molecolare:562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formula:C23H28ClN7O3SPurezza:99.77% - >99.99%Colore e forma:SolidPeso molecolare:518.03CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formula:C29H39ClN6O6SPurezza:99.79%Colore e forma:SolidPeso molecolare:635.17ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Formula:C24H23NO3SPurezza:99.83%Colore e forma:SolidPeso molecolare:405.51Ref: TM-T77754
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta500mgPrezzo su richiesta1mg39,00€5mg82,00€TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formula:C49H60ClN9O10SPurezza:98%Colore e forma:SolidPeso molecolare:1002.57ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Formula:C32H28F2N4O3Colore e forma:SolidPeso molecolare:554.586ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formula:C13H13NO3Purezza:99.54%Colore e forma:SolidPeso molecolare:231.25Ref: TM-T203011
5mg34,00€10mg46,00€1mL*10mM (DMSO)49,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formula:C43H47ClN8O7SColore e forma:SolidPeso molecolare:855.4ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 for hALK5. Administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. This compound holds potential for research in developing inhalable ALK5 inhibitors.Formula:C20H20ClFN6OPeso molecolare:414.86SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Formula:C43H49Cl2N10O7PPurezza:98%Colore e forma:SolidPeso molecolare:919.79Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Purezza:98%Colore e forma:Odour SolidTL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Formula:C45H53ClN10O10SPurezza:98%Colore e forma:SolidPeso molecolare:961.49FDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Colore e forma:LiquidRef: TM-L1610
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaZilurgisertib fumarate
CAS:Zilurgisertib fumarate is a selective ALK2 inhibitor that modulates iron metabolism and improves anemia by inhibiting SMAD phosphorylation and hepcidin production.Formula:C30H38N4O3·xC4H4O4Purezza:99.96%Colore e forma:Yellow SolidPeso molecolare:502.66 (free base)TL13-110
CAS:Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Formula:C49H62ClN9O9SColore e forma:SolidPeso molecolare:988.59
