ALK
Gli inibitori di ALK sono composti che mirano specificamente e inibiscono la chinasi del linfoma anaplastico (ALK), una tirosina chinasi recettoriale coinvolta nello sviluppo e nella progressione di alcuni tipi di cancro, inclusi il carcinoma polmonare non a piccole cellule e il neuroblastoma. Inibendo ALK, questi composti bloccano le vie di segnalazione che promuovono la crescita e la sopravvivenza delle cellule tumorali. Presso CymitQuimica, offriamo inibitori di ALK per supportare la tua ricerca in oncologia, terapie mirate contro il cancro e trasduzione del segnale.
Trovati 159 prodotti per "ALK".
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F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Formula:C22H27ClN8O3SPurezza:97.66%Colore e forma:SolidPeso molecolare:519.02LDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Formula:C25H24Cl2N6Purezza:99.87%Colore e forma:SolidPeso molecolare:479.404ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formula:C23H28ClN7O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:518.032MS4078
CAS:MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Formula:C45H52ClN9O8SPurezza:98.74%Colore e forma:Yellow SolidPeso molecolare:914.47Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Purezza:SDS-PAGE:95% SEC-HPLC:98.18%Colore e forma:Transparent LiquidPeso molecolare:~150 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurezza:98.27%Colore e forma:White SolidPeso molecolare:562.483ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formula:C23H28ClN7O3SPurezza:99.77% - >99.99%Colore e forma:SolidPeso molecolare:518.032CEP-28122 mesylate salt
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formula:C29H39ClN6O6SPurezza:99.79%Colore e forma:SolidPeso molecolare:635.17ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Formula:C24H23NO3SPurezza:99.83%Colore e forma:SolidPeso molecolare:405.51CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formula:C43H47ClN8O7SColore e forma:SolidPeso molecolare:855.4Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Colore e forma:Odour SolidEntrectinib-D8
CAS:Entrectinib-D8 is the deuterated form of Entrectinib. Entrectinib (T3678) (NMS-E628) is an orally bioavailable inhibitor that effectively crosses the blood-brain barrier and exhibits central nervous system activity. It targets TrkA/B/C, ROS1, and ALK with IC50 values of 1, 3, 5, 12, and 7 nM, respectively. Entrectinib (T3678) induces apoptosis and cell cycle arrest in cancer cells, demonstrates antitumor properties, and alleviates bleomycin-induced pulmonary fibrosis in mice.Formula:C31H34F2N6O2Peso molecolare:568.69ALK degrader 2
ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50= 102 nM). It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC).Colore e forma:Odour SolidALK2-IN-6
CAS:ALK2-IN-6 is a potent and selective ALK2 inhibitor with an IC50 of 9 nM. ALK2-IN-6 exhibits excellent brain permeability and effectively suppresses bone morphogenetic protein signaling across various preclinical cancer models for the treatment of diffuse intrinsic pontine glioma.Formula:C26H31N3O3Purezza:99.97%Colore e forma:Gray SolidPeso molecolare:433.54SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Formula:C43H49Cl2N10O7PPurezza:98%Colore e forma:SolidPeso molecolare:919.79TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formula:C49H60ClN9O10SPurezza:98%Colore e forma:SolidPeso molecolare:1002.57TL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Formula:C45H53ClN10O10SPurezza:98%Colore e forma:SolidPeso molecolare:961.49ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formula:C13H13NO3Purezza:99.54%Colore e forma:SolidPeso molecolare:231.25ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 for hALK5. Administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. This compound holds potential for research in developing inhalable ALK5 inhibitors.Formula:C20H20ClFN6OPeso molecolare:414.86TL13-110
CAS:Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Formula:C49H62ClN9O9SColore e forma:SolidPeso molecolare:988.59
