ALK
Gli inibitori di ALK sono composti che mirano specificamente e inibiscono la chinasi del linfoma anaplastico (ALK), una tirosina chinasi recettoriale coinvolta nello sviluppo e nella progressione di alcuni tipi di cancro, inclusi il carcinoma polmonare non a piccole cellule e il neuroblastoma. Inibendo ALK, questi composti bloccano le vie di segnalazione che promuovono la crescita e la sopravvivenza delle cellule tumorali. Presso CymitQuimica, offriamo inibitori di ALK per supportare la tua ricerca in oncologia, terapie mirate contro il cancro e trasduzione del segnale.
Trovati 152 prodotti per "ALK".
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LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formula:C25H26Cl4N6Purezza:98.21%Colore e forma:SolidPeso molecolare:552.33CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formula:C30H38ClN7O3Purezza:98.86% - 99.98%Colore e forma:White SolidPeso molecolare:580.12A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formula:C18H14N4Purezza:98.82% - ≥95%Colore e forma:SolidPeso molecolare:286.33Ref: TM-T2098
1mg40,00€2mg52,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg118,00€25mg200,00€50mg280,00€100mg394,00€200mg580,00€Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formula:C29H39ClN7O2PPurezza:97.18% - >99.99%Colore e forma:White SolidPeso molecolare:584.09Ref: TM-T3621
2mg34,00€5mg48,00€1mL*10mM (DMSO)62,00€10mg63,00€25mg92,00€50mg108,00€100mg158,00€200mg227,00€500mg385,00€Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formula:C30H34N4O2Purezza:98% - 99.94%Colore e forma:White SolidPeso molecolare:482.62Ref: TM-T1936
2mg44,00€5mg65,00€1mL*10mM (DMSO)70,00€10mg82,00€50mg100,00€100mg159,00€200mg245,00€500mg414,00€GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purezza:98.89% - >99.99%Colore e forma:Yellow SolidPeso molecolare:532.57LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formula:C25H22N6Purezza:98% - 99.86%Colore e forma:SolidPeso molecolare:406.48CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formula:C28H30N4O2Purezza:98.96%Colore e forma:White SolidPeso molecolare:454.56Ref: TM-T9224
1mg124,00€5mg271,00€1mL*10mM (DMSO)324,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formula:C17H13N5Purezza:99.10% - 99.92%Colore e forma:Gray SolidPeso molecolare:287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€5-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Formula:C12H9N3SPurezza:97%Colore e forma:Yellow SolidPeso molecolare:227.29Ref: TM-T50042
2mg43,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg90,00€25mg138,00€50mg200,00€100mg301,00€200mg432,00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurezza:99.13% - 99.97%Colore e forma:Cyan SolidPeso molecolare:448.95Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurezza:98.73% - 98.87%Colore e forma:SolidPeso molecolare:486.8Ref: TM-T8399
5mg34,00€1mL*10mM (DMSO)35,00€10mg50,00€25mg78,00€50mg94,00€100mg131,00€200mg162,00€500mg215,00€Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.67%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€Lorlatinib
CAS:Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormula:C21H19FN6O2Purezza:99.77% - 99.95%Colore e forma:SolidPeso molecolare:406.41Ref: TM-T3061
1mg34,00€2mg42,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg89,00€25mg137,00€50mg212,00€100mg374,00€ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Formula:C22H16N4OPurezza:99.30% - ≥95%Colore e forma:SolidPeso molecolare:352.39DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formula:C24H20N4OPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:380.44ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formula:C22H18BrN7Purezza:99.93%Colore e forma:SolidPeso molecolare:460.33Ref: TM-T9837
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta200mgPrezzo su richiesta1mg93,00€5mg182,00€1mL*10mM (DMSO)215,00€Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formula:C23H26Cl2FN5O3Colore e forma:SolidPeso molecolare:510.39GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.Formula:C25H23N5O2Purezza:98.03% - 99.58%Colore e forma:SolidPeso molecolare:425.48CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purezza:98%Colore e forma:White SolidPeso molecolare:428.53
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