ALK
Gli inibitori di ALK sono composti che mirano specificamente e inibiscono la chinasi del linfoma anaplastico (ALK), una tirosina chinasi recettoriale coinvolta nello sviluppo e nella progressione di alcuni tipi di cancro, inclusi il carcinoma polmonare non a piccole cellule e il neuroblastoma. Inibendo ALK, questi composti bloccano le vie di segnalazione che promuovono la crescita e la sopravvivenza delle cellule tumorali. Presso CymitQuimica, offriamo inibitori di ALK per supportare la tua ricerca in oncologia, terapie mirate contro il cancro e trasduzione del segnale.
Trovati 124 prodotti di "ALK"
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A 83-01
CAS:A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Formula:C25H19N5SPurezza:97% - 98.2%Colore e forma:SolidPeso molecolare:421.52Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formula:C21H22Cl2FN5OPurezza:99% - 99.87%Colore e forma:SolidPeso molecolare:450.34BIBF0775
CAS:<p>BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).</p>Formula:C31H34N4O2Purezza:99.45% - 99.79%Colore e forma:SolidPeso molecolare:494.63R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurezza:99.61%Colore e forma:SolidPeso molecolare:363.39CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formula:C28H30N4O2Purezza:98.96%Colore e forma:SolidPeso molecolare:454.56Lorlatinib
CAS:Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormula:C21H19FN6O2Purezza:99.77% - 99.95%Colore e forma:SolidPeso molecolare:406.41Ensartinib
CAS:Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).Formula:C26H27Cl2FN6O3Purezza:99.92%Colore e forma:SolidPeso molecolare:561.44DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formula:C24H20N4OPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:380.44Blu-782
CAS:<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Formula:C31H42N6O4Purezza:99.51%Colore e forma:SolidPeso molecolare:562.7LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Formula:C25H22N6Purezza:98% - 98.71%Colore e forma:SolidPeso molecolare:406.48Alectinib hydrochloride
CAS:<p>Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)</p>Formula:C30H35ClN4O2Purezza:99.61% - 99.96%Colore e forma:SolidPeso molecolare:519.08N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formula:C22H18BrN7Purezza:99.935%Colore e forma:SolidPeso molecolare:460.33ALK kinase inhibitor-1
CAS:SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Formula:C28H32FN5O3SPurezza:99.84%Colore e forma:SolidPeso molecolare:537.65A 83-01 sodium salt
CAS:A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Formula:C25H19N5NaSColore e forma:SolidPeso molecolare:444.51SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formula:C20H22ClN3O2Purezza:98.71%Colore e forma:SolidPeso molecolare:371.86AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Formula:C18H18N4O3SPurezza:98.23%Colore e forma:SolidPeso molecolare:370.43ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formula:C23H27N7OColore e forma:SolidPeso molecolare:417.51ALK5-IN-26
CAS:ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Formula:C23H17N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:427.48ALK-IN-21
CAS:ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Formula:C35H45ClN6O6S4Colore e forma:SolidPeso molecolare:809.48
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