Recettore Trk
Gli inibitori dei recettori Trk prendono di mira le chinasi recettoriali della tropomiosina (Trk), una famiglia di tirosina chinasi recettoriali che svolgono un ruolo significativo nello sviluppo e nella funzione del sistema nervoso. I recettori Trk sono coinvolti nella segnalazione delle neurotrofine, essenziale per la sopravvivenza, la differenziazione e la crescita dei neuroni. La disregolazione della segnalazione Trk è associata a disturbi neurologici e ad alcuni tipi di cancro. Presso CymitQuimica, offriamo inibitori dei recettori Trk per supportare la tua ricerca in neurobiologia, oncologia e malattie neurodegenerative.
Trovati 68 prodotti per "Recettore Trk".
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurezza:99.39% - 99.94%Colore e forma:SolidPeso molecolare:313.864CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formula:C24H22Cl2N6O3Purezza:98.99% - 99.23%Colore e forma:SolidPeso molecolare:513.38N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Formula:C12H14N2O2Purezza:98.31% - 99.91%Colore e forma:Yellow SolidPeso molecolare:218.25Luvagrobart
CAS:Luvagrobart is a human monoclonal antibody targeting NGF that inhibits NGF binding to its receptor and is used in pain therapy research.Purezza:95%Peso molecolare:~150 kDaTrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formula:C16H13N3O5Colore e forma:SolidPeso molecolare:327.08552TRK-IN-31 hydrochloride
TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. It demonstrates excellent antiproliferative activity in Ba/F3-MPRIP-TRKAG667C cells and selectively inhibits TRK kinase activity. Additionally, TRK-IN-31 hydrochloride significantly suppresses tumor growth in a Ba/F3-MPRIP-TRKAG667C subcutaneous mouse model.Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formula:C29H35F2N7O6SPurezza:98%Colore e forma:SolidPeso molecolare:647.69GNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formula:C25H27ClFN7Purezza:99.16%Colore e forma:SolidPeso molecolare:479.98Anti-NGF Antibody (5D767)
Anti-NGF Antibody (5D767) is a Rabbit IgG monoclonal antibody targeting Human NGF.Colore e forma:Odour LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formula:C25H28F4N2O6Purezza:98%Colore e forma:SolidPeso molecolare:528.49Anti-MUSK Antibody
Anti-MUSK Antibody serves as a functional therapeutic tool specifically designed to enable the precise detection and neutralization of the muscle-specific kinase which plays a pivotal role in the maintenance of the neuromuscular junction structural integrity during strictly monitored laboratory observation periods and molecular investigations to evaluate the pathological consequences of receptor tyrosine kinase inhibition in advanced neuroscience and immunology research models to facilitate the study of neuromuscular disorders.GBR-900
GBR-900 is an anti-TrkA mAb that inhibits pain signaling by blocking NGF binding, used for chronic pain with a better safety profile than anti-NGF antibodies.Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a potent monoclonal antibody targeting the TrkB/NTRK2 receptor. Anti-TrkB/NTRK2 Antibody demonstrates significant receptor engagement activity in vitro and facilitates the measurable protection of neuronal integrity while improving cognitive performance in various preclinical models of neurodegeneration.Colore e forma:Odour LiquidBelizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formula:C33H44FN5O3Purezza:99.33% - 99.44%Colore e forma:SolidPeso molecolare:577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€1mL*10mM (DMSO)105,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).Formula:C15H21N3O6Purezza:99.56%Colore e forma:SolidPeso molecolare:339.34GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formula:C28H21F4N5O2Purezza:97.26% - 98.08%Colore e forma:SolidPeso molecolare:535.49Ref: TM-T6097
5mg48,00€1mL*10mM (DMSO)52,00€10mg80,00€25mg117,00€50mg178,00€100mg295,00€200mg384,00€500mg622,00€Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formula:C20H21FN6OPurezza:99.57% - ≥95%Colore e forma:SolidPeso molecolare:380.42LOXO-195
CAS:(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formula:C20H21FN6OPurezza:99.54%Colore e forma:SolidPeso molecolare:380.42Cyclotraxin B acetate
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Formula:C50H77N13O19S3Purezza:99.73%Colore e forma:SolidPeso molecolare:1260.42Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.67%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€
