Recettore Trk
Gli inibitori dei recettori Trk prendono di mira le chinasi recettoriali della tropomiosina (Trk), una famiglia di tirosina chinasi recettoriali che svolgono un ruolo significativo nello sviluppo e nella funzione del sistema nervoso. I recettori Trk sono coinvolti nella segnalazione delle neurotrofine, essenziale per la sopravvivenza, la differenziazione e la crescita dei neuroni. La disregolazione della segnalazione Trk è associata a disturbi neurologici e ad alcuni tipi di cancro. Presso CymitQuimica, offriamo inibitori dei recettori Trk per supportare la tua ricerca in neurobiologia, oncologia e malattie neurodegenerative.
Trovati 57 prodotti di "Recettore Trk"
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N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.
Formula:C12H14N2O2Purezza:98.31% - 99.91%Colore e forma:SolidPeso molecolare:218.25CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
Formula:C24H22Cl2N6O3Purezza:98.99% - 99.23%Colore e forma:SolidPeso molecolare:513.38Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurezza:97% - 99.94%Colore e forma:Crystals White To Off-White PowderPeso molecolare:313.86GNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formula:C25H27ClFN7Purezza:98.97%Colore e forma:SolidPeso molecolare:479.98Adimanebart
CAS:Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.Colore e forma:LiquidCRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Colore e forma:Odour LiquidTrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formula:C16H13N3O5Peso molecolare:327.08552Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
Formula:C29H35F2N7O6SPurezza:98%Colore e forma:SolidPeso molecolare:647.69Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a human-derived antibody produced in CHO cells, targeting TrkB. For the isotype control of Anti-TrkB/NTRK2 Antibody, refer to HumanIgG2kappa, Isotype Control.
Colore e forma:Odour LiquidAnti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Colore e forma:Odour LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formula:C25H28F4N2O6Purezza:98%Colore e forma:SolidPeso molecolare:528.49Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.61%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formula:C20H21FN6OPurezza:99.55% - ≥95%Colore e forma:SolidPeso molecolare:380.42LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).
Formula:C15H21N3O6Purezza:99.56%Colore e forma:SolidPeso molecolare:339.34Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formula:C26H21F3N4O4Purezza:99.67% - 99.75%Colore e forma:SolidPeso molecolare:510.46Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formula:C21H22F2N6O2Purezza:99.15% - >99.99%Colore e forma:SolidPeso molecolare:428.44Ref: TM-T5995
1mg37,00€5mg74,00€10mg90,00€25mg157,00€50mg236,00€100mg356,00€500mg820,00€1mL*10mM (DMSO)81,00€CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formula:C32H31N3O5SPurezza:99.92%Colore e forma:SolidPeso molecolare:569.67Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormula:C26H29Cl4FN6O3Purezza:98.73%Colore e forma:SolidPeso molecolare:634.36Ref: TM-T22324
1mg59,00€5mg127,00€10mg188,00€25mg404,00€50mg645,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)170,00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formula:C33H44FN5O3Purezza:99.33% - 99.44%Colore e forma:SolidPeso molecolare:577.73Ref: TM-T4257
1mg43,00€2mg57,00€5mg87,00€10mg140,00€25mg274,00€50mg378,00€100mg528,00€1mL*10mM (DMSO)111,00€LOXO-195
CAS:(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formula:C20H21FN6OPurezza:99.54%Colore e forma:SolidPeso molecolare:380.42GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formula:C28H21F4N5O2Purezza:97.26% - 98.08%Colore e forma:SolidPeso molecolare:535.49Ref: TM-T6097
5mg48,00€10mg80,00€25mg117,00€50mg178,00€100mg295,00€200mg384,00€500mg622,00€1mL*10mM (DMSO)52,00€Cyclotraxin B acetate(1203586-72-4 free base)
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Formula:C50H77N13O19S3Purezza:99.42%Colore e forma:SolidPeso molecolare:1260.42DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purezza:99.75%Colore e forma:SolidPeso molecolare:735.8GW 441756
CAS:GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.Formula:C17H13N3OPurezza:97.73% - 99.8%Colore e forma:SolidPeso molecolare:275.3Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formula:C18H24N2OSPurezza:99.05%Colore e forma:SolidPeso molecolare:316.46ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
Formula:C32H26N4O6Purezza:98.74%Colore e forma:SolidPeso molecolare:562.57ANA-12
CAS:ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
Formula:C22H21N3O3SPurezza:99.28% - 99.87%Colore e forma:SolidPeso molecolare:407.497,8-Dihydroxyflavone
CAS:7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.Formula:C15H10O4Purezza:98.48% - 99.81%Colore e forma:SolidPeso molecolare:254.24Repotrectinib
CAS:Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
Formula:C18H18FN5O2Purezza:99.92% - >99.99%Colore e forma:SolidPeso molecolare:355.37Larotrectinib sulfate
CAS:Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).Formula:C21H22F2N6O2·H2O4SPurezza:98.62% - 99.76%Colore e forma:SolidPeso molecolare:526.51Ref: TM-T6880
2mg37,00€5mg54,00€10mg88,00€25mg124,00€50mg155,00€100mg259,00€500mg623,00€1mL*10mM (DMSO)63,00€LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formula:C27H33ClN2O4Purezza:98.18%Colore e forma:SolidPeso molecolare:485.01Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormula:C33H29F2N5O4SPurezza:98.9% - 99.85%Colore e forma:SolidPeso molecolare:629.68Ref: TM-T4349
5mg51,00€10mg79,00€25mg137,00€50mg210,00€100mg338,00€200mg535,00€500mg845,00€1mL*10mM (DMSO)72,00€Frunevetmab
CAS:Frunevetmab (NV-02) is a feline-adapted monoclonal antibody targeting NGF (nerve growth factor), with a Kd value of 20 pM. Feline osteoarthritis (OA).
Purezza:95% - 95%Colore e forma:LiquidFasinumab
CAS:Fasinumab (anti-NGF mAb) is in Phase III trials for acute sciatica & knee OA. It significantly improves pain & function vs. placebo.Purezza:95%Colore e forma:LiquidTanezumab
CAS:Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF，pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.Purezza:95%Colore e forma:LiquidPeso molecolare:145.43 kDaFulranumab
CAS:Fulranumab (AMG-403) is a humanised monoclonal antibody targeting NGF, analgesic effects, and can be used for the study of chronic pain.Purezza:95%Colore e forma:LiquidTrkA-IN-1
CAS:TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Formula:C25H20N4OPurezza:98%Colore e forma:SolidPeso molecolare:392.45Tavilermide
CAS:Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.Formula:C24H32N6O11Purezza:98.98%Colore e forma:SolidPeso molecolare:580.54Protein kinase inhibitor 5
CAS:Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Formula:C29H31F2N7OPurezza:98%Colore e forma:SolidPeso molecolare:531.6Paltimatrectinib
CAS:Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Formula:C20H15F5N6Purezza:99.96%Colore e forma:SolidPeso molecolare:434.37Type II TRK inhibitor 1
CAS:Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Formula:C35H33F3N8O3Purezza:98%Colore e forma:SolidPeso molecolare:670.68ENT-C225
CAS:ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Formula:C26H40N4O5Purezza:99.36% - 99.36%Colore e forma:SolidPeso molecolare:488.62PF-06733804
CAS:PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.Formula:C20H19F5N4O4Purezza:98%Colore e forma:SolidPeso molecolare:474.38TRK-IN-24
CAS:TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,Formula:C39H45N7O3Purezza:98%Colore e forma:SolidPeso molecolare:659.82AZ-23
CAS:AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.Formula:C17H19ClFN7OPurezza:99.4%Colore e forma:SolidPeso molecolare:391.83BNN-20
CAS:BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.Formula:C20H30O2Colore e forma:SolidPeso molecolare:302.45ONO-7579
CAS:ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.Formula:C24H18ClF3N6O4SColore e forma:SolidPeso molecolare:578.95TRK-IN-26
CAS:TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].Formula:C30H22F2N6O4Colore e forma:SolidPeso molecolare:568.53NMS-P626
CAS:NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.
Formula:C28H35F2N7O4SColore e forma:SolidPeso molecolare:603.68TRK-IN-28
CAS:TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].Formula:C27H25F2N7Colore e forma:SolidPeso molecolare:485.53TrkA-IN-8
CAS:TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.Formula:C20H16N4Colore e forma:SolidPeso molecolare:312.368TrkA-IN-9
CAS:TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.Formula:C31H32N4O4Colore e forma:SolidPeso molecolare:524.61PF-06273340
CAS:PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。Formula:C23H22ClN7O3Purezza:98% - 98.00%Colore e forma:SolidPeso molecolare:479.92TrkA-IN-7
CAS:TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.
Formula:C16H13N3O3Colore e forma:SolidPeso molecolare:295.293TrkC-IN-1
CAS:TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.Formula:C28H20BrN5O2Colore e forma:SolidPeso molecolare:538.395Trk-IN-4
CAS:Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor and antinociceptive. It is also a selective type II PTK6 inhibitor antitumor.Formula:C24H23F4N5O4Purezza:98.13%Colore e forma:SolidPeso molecolare:521.46TrkB-IN-1
CAS:TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.
Formula:C19H16N2O6Purezza:98%Colore e forma:SolidPeso molecolare:368.34
