c-Met/HGFR
Gli inibitori di c-Met/HGFR mirano al Recettore del Fattore di Crescita degli Epatociti (c-Met), una tirosina chinasi coinvolta in processi cellulari come crescita, motilità e morfogenesi. La segnalazione di c-Met è implicata nella progressione del cancro, nella metastasi e nella resistenza alle terapie. L'inibizione di c-Met può interrompere la crescita e la diffusione del tumore, rendendo questi inibitori preziosi nella ricerca sul cancro. Presso CymitQuimica, offriamo inibitori di c-Met/HGFR per supportare la tua ricerca in oncologia, metastasi e terapie oncologiche mirate.
Trovati 137 prodotti di "c-Met/HGFR"
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c-Met inhibitor 1
CAS:c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer.Formula:C17H14N8SPurezza:98.77%Colore e forma:SolidPeso molecolare:362.41JNJ-38877618
CAS:JNJ-38877618 (OMO-1) is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively).Formula:C20H12F2N6Purezza:98.84% - 99.74%Colore e forma:SolidPeso molecolare:374.35Emibetuzumab
CAS:Emibetuzumab: potent humanized MET antibody, antitumor, inhibits HGF/MET pathways, for advanced prostate cancer research.Purezza:SDS-PAGE:96.2%;SEC-HPLC:98.8%Colore e forma:LiquidPeso molecolare:143.74 kDaCSF1R-IN-2
CAS:CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formula:C20H20FN7O2Purezza:99.29%Colore e forma:SolidPeso molecolare:409.42Rilotumumab
CAS:<p>Rilotumumab (AMG 102) is an HGF-targeting antibody, inhibits HGF/MET signaling, and is used for CRPC and gastric cancer research.</p>Purezza:SDS-PAGE:95% SEC-HPLC:97.51%Colore e forma:LiquidPeso molecolare:145.2 kDaPamufetinib
CAS:Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase.Formula:C27H23FN4O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:518.56Bozitinib
CAS:<p>Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability.</p>Formula:C20H15F3N8Purezza:99.16%Colore e forma:SolidPeso molecolare:424.38SU 5616
CAS:<p>SU 5616 (WAY-608241) regulates abnormal cell proliferation and modulates tyrosine kinase signaling.</p>Formula:C13H8ClNOSPurezza:98.84%Colore e forma:SoildPeso molecolare:261.73Onartuzumab
CAS:Onartuzumab (MetMAb) is a humanized monoclonal antibody targeting c-MET, with antitumor effects by blocking HGF and signal transduction.Purezza:97.3%Colore e forma:LiquidPeso molecolare:146.99 kDac-Met ligand-Linker Conjugate 1
c-Met ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that consists of a c-Met ligand and a PROTAC linker, capable of recruiting E3 ligase. This compound is used in the synthesis of PROTACc-Met degrader-5.Colore e forma:Odour SolidPROTAC c-Met degrader-2
CAS:PROTACc-Met degrader-2 (PROTAC2) is a c-Met degrader developed using PROTAC technology, with a DC50 value of 50 nM.Formula:C51H50F2N6O13Peso molecolare:992.97Umikibart
Umikibart is a humanized IgG4κ antibody targeting HGF, with the corresponding isotype control being HumanIgG4(S228P) kappa, Isotype Control.Colore e forma:Odour Liquidc-Met-IN-23
c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.Formula:C16H13N7OPeso molecolare:319.11816PROTAC c-Met degrader-1
CAS:PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC50 of 4.37 nM and causes cell cycle arrest in the G0/G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.Formula:C45H41FN10O5Colore e forma:SolidPeso molecolare:820.87PF-04217903 phenolsulfonate
CAS:PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Formula:C25H22N8O5SPurezza:98%Colore e forma:SolidPeso molecolare:546.56PROTAC c-Met degrader-3
PROTACc-Met degrader-3 (Compound 22b) is a c-Met PROTAC degrader. It facilitates the ubiquitination and degradation of c-Met, with a DC50 of 0.59 nM in EBC-1 cells. PROTACc-Met degrader-3 is applicable in lung cancer research.Formula:C51H54N10O7Colore e forma:SolidPeso molecolare:919.037Norleual
CAS:<p>Angiotensin IV analog, potent HGF/c-MET inhibitor (IC50=3 pM), halts MDCK cell growth and invasion, AT4 antagonist, impairs LTP, antiangiogenic.</p>Formula:C41H58N8O7Purezza:98%Colore e forma:SolidPeso molecolare:774.95LMTK3-IN-1
CAS:Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.Formula:C18H11F3N4OPurezza:99.58%Colore e forma:SoildPeso molecolare:356.3BMS-777607
CAS:BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.Formula:C25H19ClF2N4O4Purezza:98.16% - 98.56%Colore e forma:SolidPeso molecolare:512.89Fosgonimeton acetate
Fosgonimeton acetate is an agonist of hepatocyte growth factor (HGF).Formula:C29H49N4O10PPurezza:98.01%Colore e forma:SolidPeso molecolare:644.69
