c-RET
Gli inibitori di c-RET prendono di mira il proto-oncogene RET (Rearranged during Transfection), che codifica una tirosina chinasi recettoriale coinvolta nella crescita, differenziazione e sopravvivenza cellulare. L'attivazione anomala della segnalazione RET può portare a una proliferazione cellulare incontrollata e alla resistenza all'apoptosi, contribuendo allo sviluppo di tumori come il carcinoma midollare della tiroide e il carcinoma polmonare non a piccole cellule. L'inibizione di c-RET può indurre l'apoptosi nelle cellule tumorali ed è un approccio promettente nella terapia oncologica mirata. Presso CymitQuimica, offriamo una varietà di inibitori di c-RET di alta qualità per supportare la tua ricerca in oncologia, trasduzione del segnale e apoptosi.
Trovati 64 prodotti per "c-RET".
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Pyrazoloadenine
CAS:Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.Formula:C5H5N5Purezza:99.02%Colore e forma:SolidPeso molecolare:135.13SPP-86
CAS:SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.Formula:C16H15N5Purezza:99.53%Colore e forma:SolidPeso molecolare:277.32Ref: TM-T16923
1mg46,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg144,00€25mg281,00€50mg447,00€100mg650,00€500mg1.369,00€WHI-P180 hydrochloride
CAS:WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.Formula:C16H16ClN3O3Colore e forma:SolidPeso molecolare:333.77Pralsetinib
CAS:Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918TFormula:C27H32FN9O2Purezza:97.88% - 99.8%Colore e forma:White SolidPeso molecolare:533.6WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purezza:99.21%Colore e forma:White SolidPeso molecolare:297.31AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurezza:99.49% - 99.75%Colore e forma:SolidPeso molecolare:473.43Ref: TM-T4301
1mg44,00€1mL*10mM (DMSO)90,00€5mg96,00€10mg138,00€25mg268,00€50mg439,00€100mg645,00€500mg1.333,00€Treprostinil Sodium
CAS:Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).Formula:C23H33NaO5Purezza:99.67% - >99.99%Colore e forma:SolidPeso molecolare:412.5GSK3179106
CAS:GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nMFormula:C22H21F4N3O4Purezza:99.8% - 99.90%Colore e forma:SolidPeso molecolare:467.41Selpercatinib
CAS:"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."Formula:C29H31N7O3Purezza:99.87% - >99.99%Colore e forma:White SolidPeso molecolare:525.6Ref: TM-T8222
2mg34,00€5mg49,00€1mL*10mM (DMSO)56,00€10mg84,00€25mg166,00€50mg259,00€100mg477,00€200mg692,00€500mg1.035,00€RET V804M-IN-1
CAS:RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).Formula:C19H16N6OPurezza:97.94% - 99.62%Colore e forma:White SolidPeso molecolare:344.37Ref: TM-T8467
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg90,00€25mg157,00€50mg236,00€100mg334,00€200mg495,00€BBT594
CAS:BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.Formula:C28H30F3N7O3Purezza:99.57%Colore e forma:White SolidPeso molecolare:569.58RET-IN-16
CAS:RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.Formula:C31H29F3N8O2Colore e forma:SolidPeso molecolare:602.61RET-IN-6
CAS:RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).Formula:C30H29N7Colore e forma:SolidPeso molecolare:487.6RET-IN-22
CAS:RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-Formula:C29H31F3N6O4Colore e forma:SolidPeso molecolare:584.59DUN73423
CAS:DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.Formula:C19H16N6OPurezza:98.03%Colore e forma:SolidPeso molecolare:344.37XMD15-44
CAS:XMD15-44, a RET kinase inhibitor, demonstrates potent growth-inhibitory effects on RAT1 cells transformed by RET/C634R and RET/M918T, with IC50 values of 11.5 nM and 8.3 nM, respectively. It effectively inhibits RET kinase activity and signaling in human thyroid cancer cell lines harboring oncogenic RET alleles, thereby reducing cell proliferation.Formula:C29H29F3N4OColore e forma:SolidPeso molecolare:506.56RET-IN-8
CAS:RET-IN-8 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Formula:C27H30N6O3Colore e forma:SolidPeso molecolare:486.57RET-IN-12
CAS:RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).Formula:C30H30F3N5O4Colore e forma:SolidPeso molecolare:581.59RET-IN-15
CAS:RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Formula:C27H28N8O2Colore e forma:SolidPeso molecolare:496.56TRK II-IN-1
CAS:TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Formula:C29H31F3N8OPurezza:98%Colore e forma:SolidPeso molecolare:564.6
