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FLT

FLT

Gli inibitori della FLT (Fms-like tyrosine kinase) sono composti che prendono di mira i recettori FLT, coinvolti nella regolazione dell'angiogenesi attraverso la via del VEGF (fattore di crescita endoteliale vascolare). I recettori FLT svolgono un ruolo cruciale nello sviluppo di nuovi vasi sanguigni nei tumori. Inibendo i recettori FLT, è possibile ridurre efficacemente l'angiogenesi e la crescita tumorale, rendendo questi inibitori importanti nella terapia del cancro. Presso CymitQuimica, offriamo una selezione di inibitori della FLT di alta qualità per supportare la tua ricerca in oncologia, biologia vascolare e angiogenesi.

Trovati 88 prodotti di "FLT"

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  • FLT3/ITD-IN-3
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    FLT3/ITD-IN-3

    CAS:
    <p>FLT3/ITD-IN-3 (Compound 19) is a potent FLT3-ITD inhibitor with IC50 values: FLT3D835Y (0.3 nM), FLT3 (0.4 nM), inhibits AML cell proliferation.</p>
    Formula:C22H26ClN7O2
    Colore e forma:Solid
    Peso molecolare:455.94

    Ref: TM-T62824

  • KRN383
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    KRN383

    CAS:
    KRN383 inhibits ITD cell growth at ≤2.9 nM, erases ITD tumors in mice at 80 mg/kg dose, and may suit various treatment plans.
    Formula:C17H17N3O4
    Colore e forma:Solid
    Peso molecolare:327.33

    Ref: TM-T68346

  • FN-1501
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    FN-1501

    CAS:
    <p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>
    Formula:C22H25N9O
    Purezza:97.4%
    Colore e forma:Solid
    Peso molecolare:431.49

    Ref: TM-T15335

  • FLT3-IN-12
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    FLT3-IN-12

    CAS:
    FLT3-IN-12: potent, selective oral FLT3 inhibitor; FLT3-WT IC50: 1.48 nM, FLT3-D835Y: 2.87 nM; >1000x selective over c-KIT; anti-AML, IC50: 0.75 nM MV4-11.
    Formula:C21H23F3N6O
    Colore e forma:Solid
    Peso molecolare:432.44

    Ref: TM-T62412

  • FLT3-IN-15
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    FLT3-IN-15

    CAS:
    FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).
    Formula:C22H23ClFN5O2
    Colore e forma:Solid
    Peso molecolare:443.91

    Ref: TM-T62607

  • FLT3-IN-18
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    FLT3-IN-18

    CAS:
    FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.
    Formula:C26H36N8O
    Colore e forma:Solid
    Peso molecolare:476.62

    Ref: TM-T73142

  • FLT3/D835Y-IN-1
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    FLT3/D835Y-IN-1

    CAS:
    FLT3/D835Y-IN-1, an oral FLT3 inhibitor (IC50: FLT3 - 0.26 nM, D835Y - 0.18 nM), shows anticancer potential in AML research.
    Formula:C22H21N5O3
    Colore e forma:Solid
    Peso molecolare:403.43

    Ref: TM-T61977

  • AGL 2043
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    AGL 2043

    CAS:
    AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.
    Formula:C15H12N4S
    Colore e forma:Solid
    Peso molecolare:280.35

    Ref: TM-T26576

  • MDK5466
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    MDK5466

    CAS:
    MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.
    Formula:C21H23N3OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:365.49

    Ref: TM-T24438

  • PDGFRα/FLT3-ITD-IN-1
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    PDGFRα/FLT3-ITD-IN-1

    CAS:
    PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively.
    Formula:C27H39N9O
    Colore e forma:Solid
    Peso molecolare:505.66

    Ref: TM-T63454

  • BSc5371
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    BSc5371

    CAS:
    BSc5371: Irreversible FLT3 inhibitor; Kds 0.83-5.8 nM for various FLT3 mutants including wild type.
    Formula:C24H31N5O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:485.6

    Ref: TM-T10622

  • PDGFRα/FLT3-ITD-IN-3
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    PDGFRα/FLT3-ITD-IN-3

    CAS:
    PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be
    Formula:C26H39N9
    Colore e forma:Solid
    Peso molecolare:477.65

    Ref: TM-T63127

  • FLT3-IN-11
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    FLT3-IN-11

    CAS:
    FLT3-IN-11, an oral FLT3 kinase inhibitor: potent, selective, IC50 - wild-type 7.22 nM, FLT3-D835Y 4.95 nM, anti-AML IC50 3.2 nM for MV4-11.
    Formula:C20H25F3N6O
    Colore e forma:Solid
    Peso molecolare:422.45

    Ref: TM-T62260

  • HP1328
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    HP1328

    CAS:
    HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.
    Formula:C23H23N3O3
    Colore e forma:Solid
    Peso molecolare:389.45

    Ref: TM-T61758

  • TG-46
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    TG-46

    CAS:
    TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.
    Formula:C26H34N6O3S
    Purezza:98.82% - 99.86%
    Colore e forma:Solid
    Peso molecolare:510.65

    Ref: TM-T20743

  • Gilteritinib hemifumarate
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    Gilteritinib hemifumarate

    CAS:
    <p>Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of</p>
    Formula:C29H44N8O3C4H4O4
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:610.75

    Ref: TM-T71973

  • AXL-IN-13
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    AXL-IN-13

    CAS:
    AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.
    Formula:C34H41FN6O5
    Purezza:99.95%
    Colore e forma:Solid
    Peso molecolare:632.72

    Ref: TM-T73300

  • AC710
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    AC710

    CAS:
    <p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>
    Formula:C31H42N6O4
    Purezza:99.67%
    Colore e forma:Solid
    Peso molecolare:562.7

    Ref: TM-TQ0235

  • FLT3/ITD-IN-2
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    FLT3/ITD-IN-2

    CAS:
    <p>FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.</p>
    Formula:C23H26F3N7O2
    Colore e forma:Solid
    Peso molecolare:489.49

    Ref: TM-T63274

  • JNJ-47117096 hydrochloride
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    JNJ-47117096 hydrochloride

    CAS:
    JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.
    Formula:C21H23ClN4O2
    Colore e forma:Solid
    Peso molecolare:398.89

    Ref: TM-T11725

  • FLT3-IN-6
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    FLT3-IN-6

    CAS:
    FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.
    Formula:C23H25N5O3
    Colore e forma:Solid
    Peso molecolare:419.48

    Ref: TM-T11300

  • AAE871
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    AAE871

    CAS:
    <p>AAE871 is a type I FLT3 inhibitor.</p>
    Formula:C24H34N8O2S
    Colore e forma:Solid
    Peso molecolare:498.64

    Ref: TM-T69497

  • GTP-14564
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    GTP-14564

    CAS:
    <p>GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.</p>
    Formula:C15H10N2O
    Purezza:99.69%
    Colore e forma:Solid
    Peso molecolare:234.25

    Ref: TM-T71857

  • TG-89
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    TG-89

    CAS:
    <p>TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian and</p>
    Formula:C26H34N6O3S
    Purezza:98.68%
    Colore e forma:Solid
    Peso molecolare:510.65

    Ref: TM-T20742

  • HPK1-IN-2 dihydrochloride
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    HPK1-IN-2 dihydrochloride

    CAS:
    HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].
    Formula:C19H22Cl2N6OS
    Colore e forma:Solid
    Peso molecolare:453.39

    Ref: TM-T84714

  • SG3-179
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    SG3-179

    CAS:
    SG3-179 is a BET inhibitor.
    Formula:C28H35ClFN7O3S
    Colore e forma:Solid
    Peso molecolare:604.14

    Ref: TM-T70100

  • TAK-659
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    TAK-659

    CAS:
    TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.
    Formula:C17H21FN6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:344.39

    Ref: TM-T21062

  • UNC4203
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    UNC4203

    CAS:
    UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.
    Formula:C30H44N6O
    Colore e forma:Solid
    Peso molecolare:504.71

    Ref: TM-T63444

  • OTS447
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    OTS447

    CAS:
    OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .
    Formula:C27H32ClN3O2
    Purezza:98.78%
    Colore e forma:Solid
    Peso molecolare:466.02

    Ref: TM-T62979

  • FLT3/ITD-IN-5
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    FLT3/ITD-IN-5

    CAS:
    FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.
    Formula:C23H25N7O2
    Colore e forma:Solid
    Peso molecolare:431.49

    Ref: TM-T88606

  • Lomonitinib
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    Lomonitinib

    CAS:
    <p>Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.</p>
    Formula:C27H24N4O2
    Colore e forma:Solid
    Peso molecolare:436.505

    Ref: TM-T205470

  • TTT 3002
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    TTT 3002

    CAS:
    TTT 3002: oral FLT3 inhibitor for AML research, blocks D835 mutations, potent at 0.2 nM IC50.
    Formula:C27H23N5O3
    Colore e forma:Solid
    Peso molecolare:465.50

    Ref: TM-T73349

  • Multi-kinase inhibitor 4
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    Multi-kinase inhibitor 4

    CAS:
    Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.
    Formula:C25H24N6O2
    Colore e forma:Solid
    Peso molecolare:440.50

    Ref: TM-T201144

  • Logo CymitQuimica
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    FLT3/ITD-IN-1

    FLT3/ITD-IN-1 inhibits FLT3-ITD with IC50s: 38.2 nM (FLT3) and 144.1 nM (ITD), and fights acute myeloid leukemia.
    Formula:C19H22N6O2
    Colore e forma:Solid
    Peso molecolare:366.42

    Ref: TM-T61415

  • Multi-kinase inhibitor 3
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    Multi-kinase inhibitor 3

    CAS:
    <p>Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.</p>
    Formula:C26H26N6O2
    Colore e forma:Solid
    Peso molecolare:454.52

    Ref: TM-T200518

  • JNJ-47117096
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    JNJ-47117096

    CAS:
    <p>JNJ-47117096 is a potent and selective MELK inhibitor with an IC50 of 23 nM, and it also exhibits strong activity against Flt3 with an IC50 of 18 nM.</p>
    Formula:C21H22N4O2
    Colore e forma:Solid
    Peso molecolare:362.425

    Ref: TM-T204607

  • E6201
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    E6201

    CAS:
    E6201, a dual kinase inhibitor, blocks MEK1/FLT3 and has anti-tumor/psoriasis effects with low IC50s: ERK2 (5.2 nM), JNK (91 nM), p38 MAPK (19 nM).
    Formula:C21H27NO6
    Colore e forma:Solid
    Peso molecolare:389.44

    Ref: TM-T61755

  • Logo CymitQuimica
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    LT-850-166

    LT-850-166 is a potent inhibitor of FLT3 and has shown efficacy in overcoming a wide range of FLT3 mutations.
    Formula:C30H29Cl2N7O
    Colore e forma:Solid
    Peso molecolare:574.5

    Ref: TM-T64062