FLT
Gli inibitori della FLT (Fms-like tyrosine kinase) sono composti che prendono di mira i recettori FLT, coinvolti nella regolazione dell'angiogenesi attraverso la via del VEGF (fattore di crescita endoteliale vascolare). I recettori FLT svolgono un ruolo cruciale nello sviluppo di nuovi vasi sanguigni nei tumori. Inibendo i recettori FLT, è possibile ridurre efficacemente l'angiogenesi e la crescita tumorale, rendendo questi inibitori importanti nella terapia del cancro. Presso CymitQuimica, offriamo una selezione di inibitori della FLT di alta qualità per supportare la tua ricerca in oncologia, biologia vascolare e angiogenesi.
Trovati 88 prodotti di "FLT"
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BSc5371
CAS:BSc5371: Irreversible FLT3 inhibitor; Kds 0.83-5.8 nM for various FLT3 mutants including wild type.Formula:C24H31N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:485.6PDGFRα/FLT3-ITD-IN-3
CAS:PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to beFormula:C26H39N9Colore e forma:SolidPeso molecolare:477.65FLT3-IN-11
CAS:FLT3-IN-11, an oral FLT3 kinase inhibitor: potent, selective, IC50 - wild-type 7.22 nM, FLT3-D835Y 4.95 nM, anti-AML IC50 3.2 nM for MV4-11.Formula:C20H25F3N6OColore e forma:SolidPeso molecolare:422.45HP1328
CAS:HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.Formula:C23H23N3O3Colore e forma:SolidPeso molecolare:389.45TG-46
CAS:TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Formula:C26H34N6O3SPurezza:98.82% - 99.86%Colore e forma:SolidPeso molecolare:510.65Gilteritinib hemifumarate
CAS:<p>Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of</p>Formula:C29H44N8O3C4H4O4Purezza:99.78%Colore e forma:SolidPeso molecolare:610.75AXL-IN-13
CAS:AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.Formula:C34H41FN6O5Purezza:99.95%Colore e forma:SolidPeso molecolare:632.72AC710
CAS:<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Formula:C31H42N6O4Purezza:99.67%Colore e forma:SolidPeso molecolare:562.7FLT3/ITD-IN-2
CAS:<p>FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.</p>Formula:C23H26F3N7O2Colore e forma:SolidPeso molecolare:489.49JNJ-47117096 hydrochloride
CAS:JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.Formula:C21H23ClN4O2Colore e forma:SolidPeso molecolare:398.89FLT3-IN-6
CAS:FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.Formula:C23H25N5O3Colore e forma:SolidPeso molecolare:419.48AAE871
CAS:<p>AAE871 is a type I FLT3 inhibitor.</p>Formula:C24H34N8O2SColore e forma:SolidPeso molecolare:498.64GTP-14564
CAS:<p>GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.</p>Formula:C15H10N2OPurezza:99.69%Colore e forma:SolidPeso molecolare:234.25TG-89
CAS:<p>TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian and</p>Formula:C26H34N6O3SPurezza:98.68%Colore e forma:SolidPeso molecolare:510.65HPK1-IN-2 dihydrochloride
CAS:HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].Formula:C19H22Cl2N6OSColore e forma:SolidPeso molecolare:453.39SG3-179
CAS:SG3-179 is a BET inhibitor.Formula:C28H35ClFN7O3SColore e forma:SolidPeso molecolare:604.14TAK-659
CAS:TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Formula:C17H21FN6OPurezza:98%Colore e forma:SolidPeso molecolare:344.39UNC4203
CAS:UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.Formula:C30H44N6OColore e forma:SolidPeso molecolare:504.71OTS447
CAS:<p>OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .</p>Formula:C27H32ClN3O2Purezza:98.78%Colore e forma:SolidPeso molecolare:466.02FLT3/ITD-IN-5
CAS:FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Formula:C23H25N7O2Colore e forma:SolidPeso molecolare:431.49
