IGF-1R
Gli inibitori di IGF-1R sono composti che prendono di mira specificamente il recettore del fattore di crescita insulino-simile 1 (IGF-1R), una tirosina chinasi recettore coinvolta nella crescita, sviluppo e sopravvivenza cellulare. La segnalazione dell'IGF-1R svolge un ruolo significativo nella progressione del cancro, rendendo questi inibitori preziosi nella ricerca oncologica. Presso CymitQuimica, offriamo inibitori di IGF-1R per supportare la tua ricerca in biologia del cancro, endocrinologia e sviluppo di terapie mirate.
Trovati 104 prodotti di "IGF-1R"
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Ganitumab
CAS:Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:145.70 kDaRobatumumab
CAS:Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.Purezza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Colore e forma:LiquidMSDC-0602K
CAS:MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.Formula:C19H16KNO5SPurezza:99.42%Colore e forma:SolidPeso molecolare:409.5AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purezza:99.65%Colore e forma:SolidPeso molecolare:522.04ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurezza:98.27%Colore e forma:SolidPeso molecolare:562.48Ref: TM-T10285
1mg50,00€5mg110,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€1mL*10mM (DMSO)136,00€GIP (human) acetate
GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.Purezza:98.65%Colore e forma:SoildGIP (3-42), human
CAS:Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.Formula:C214H324N58O63SPurezza:95.73%Colore e forma:SolidPeso molecolare:4749.35Insulin α-chain (1-13)
CAS:Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.Formula:C66H118N20O22S3Purezza:98%Colore e forma:SolidPeso molecolare:1639.96IGF-I (24-41)
CAS:IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.
Formula:C88H133N27O28Purezza:98%Colore e forma:SolidPeso molecolare:2017.16Xenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Formula:C53H83N15O11Purezza:95.54%Colore e forma:SoildPeso molecolare:1106.32cis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Formula:C28H31N5OColore e forma:SolidPeso molecolare:453.59Proinsulin C-Peptide (55-89), human
CAS:Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Formula:C153H259N49O52Purezza:98%Colore e forma:SolidPeso molecolare:3616.99GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismPurezza:98%Colore e forma:LiquidHNMPA
CAS:HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.
Formula:C11H11O4PPurezza:99.18%Colore e forma:SolidPeso molecolare:238.18Ref: TM-T21761
1mg50,00€2mg65,00€5mg93,00€10mg144,00€25mg301,00€50mg452,00€100mg660,00€500mg1.396,00€INSR agonist 1
INSR agonist 1, an insulin receptor (INSR) agonist, effectively elevates INSR pY1355/1361 levels and exhibits synergistic effects with insulin.Formula:C36H47BrN4O6Colore e forma:SolidPeso molecolare:711.69GIP, human
CAS:Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.
Formula:C226H338N60O66SPurezza:98%Colore e forma:SolidPeso molecolare:4983.6[Pro3]-GIP (Mouse)
GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.Formula:C225H342N62O64SPurezza:98%Colore e forma:SolidPeso molecolare:4971.62AVE1642
AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidOI338
OI338 is an orally available, ultralong-acting insulin analogue.Formula:C260H403N65O84S6Colore e forma:SolidPeso molecolare:5971.76[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Formula:C72H110N19O33P3Purezza:98%Colore e forma:SolidPeso molecolare:1862.67CPF-7
CAS:CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulationFormula:C118H193N33O32Colore e forma:SolidPeso molecolare:2586LDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Formula:C55H59F2N11O6Colore e forma:SolidPeso molecolare:1008.12C-Peptide 2, rat
CAS:C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.Formula:C135H222N38O49Colore e forma:SolidPeso molecolare:3161.478TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Formula:C24H28NO7PSPurezza:98%Colore e forma:SolidPeso molecolare:505.52IGF-I (30-41)
CAS:IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).Formula:C51H83N19O19Purezza:98%Colore e forma:SolidPeso molecolare:1266.34TLK19781
CAS:TLK19781 is an insulin receptor modulator.Formula:C33H24Cl2N4O13S4Purezza:98%Colore e forma:SolidPeso molecolare:883.73Proinsulin C-peptide (human)
CAS:C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.Formula:C129H211N35O48Purezza:98%Colore e forma:SolidPeso molecolare:3020.26Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.
Formula:C225H342N60O66S·XCF3COOHColore e forma:SolidPeso molecolare:4975.55GIP (1-39)
CAS:Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.Formula:C210H316N56O61SPurezza:98%Colore e forma:SolidPeso molecolare:4633.21Teprotumumab
CAS:Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.
Purezza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Colore e forma:LiquidPeso molecolare:145.62 kDaCixutumumab
CAS:Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impedingPurezza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:LiquidInsulin efsitora alfa
CAS:Insulin efsitora alfa(LY-3209590) is an IR agonist and a fusion protein that binds a novel single-chain insulin variant to the structural domain of human IgG FcPurezza:98.3% (SDS-PAGE); 98.1% (SEC-HPLC) - 98.3% (SDS-PAGE); 98.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:32.04 kDaInsulin glulisine
CAS:Insulin glulisine (HMR 1964), a rapid-acting analogue, mimics human insulin; used in diabetes research.Formula:C258H384N64O78S6Colore e forma:SolidPeso molecolare:5822.57[D-Ala2]-GIP (human)
CAS:Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.Formula:C226H338N60O66SPurezza:98%Colore e forma:SolidPeso molecolare:4983.58Xenin-8
CAS:neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effectsFormula:C51H79N15O9Purezza:98%Colore e forma:SolidPeso molecolare:1046.27IGF-1R inhibitor-2
CAS:IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.Formula:C24H24FN7O2Colore e forma:SolidPeso molecolare:461.501GIP (1-30) amide,human
CAS:GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Formula:C162H240N40O47SPurezza:98%Colore e forma:SolidPeso molecolare:3531.94Valanafusp alfa
CAS:Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.Colore e forma:LiquidWAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Formula:C18H16N2O2Purezza:99.97%Colore e forma:SoildPeso molecolare:292.33PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79Insulin sensitizer C59
CAS:Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.Formula:C16H18Cl2N2OPurezza:99.98%Colore e forma:SoildPeso molecolare:325.23ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Formula:C39H40N6O3Purezza:98.34% - 99.32%Colore e forma:SolidPeso molecolare:640.77Acetyl Gastric Inhibitory Peptide (human)
CAS:Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Formula:C228H340N60O67SColore e forma:SolidPeso molecolare:5025.6Insulin peglispro
CAS:Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.Formula:C370H566N104O110S4Colore e forma:SolidPeso molecolare:8359.32(Pro3) GIP, human
CAS:(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.Formula:C226H338N60O64SColore e forma:SolidPeso molecolare:4951.53DA-JC4
CAS:DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.Formula:C225H346N56O65Colore e forma:SolidPeso molecolare:4875.49Macupatide
CAS:Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Colore e forma:SolidGIP (1-30) amide, porcine TFA
GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.Colore e forma:LiquidNBI-31772
CAS:NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Formula:C17H11NO7Purezza:99.79%Colore e forma:SolidPeso molecolare:341.27IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColore e forma:Lyophilized PowderPeso molecolare:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Purezza:> 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLCColore e forma:Lyophilized PowderPeso molecolare:80.72+23.0 kDa (predicted); 110-140 kDa and 50-65 kDa, corresponding to the α subunit and β subunit respectively (reducing condition, due to glycosylation)Ref: TM-TMPY-06195
1mg4.244,00€5µg90,00€10µg129,00€20µg204,00€50µg406,00€100µg672,00€200µg1.170,00€500µg2.405,00€IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColore e forma:Lyophilized PowderPeso molecolare:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.HNMPA-(AM)3
CAS:HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。Formula:C20H23O10PPurezza:97.22%Colore e forma:SolidPeso molecolare:454.36IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColore e forma:Lyophilized PowderPeso molecolare:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.Ref: TM-TMPK-00456
5µg97,00€10µg157,00€20µg252,00€50µg497,00€100µg823,00€200µg1.488,00€500µg3.185,00€IMP2-IN-1
CAS:IMP2-IN-1 effectively inhibits IMP2 (IC50: 81.3-127.5 μM), reduces IMP2 in SW480 cells, and hinders Huh7 cell activity.Formula:C21H14F3NO4Colore e forma:SolidPeso molecolare:401.34XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurezza:99.07%Colore e forma:SolidPeso molecolare:437.54Ref: TM-T17267
1mg52,00€2mg73,00€5mg94,00€10mg141,00€25mg244,00€50mg371,00€100mg552,00€1mL*10mM (DMSO)104,00€NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Formula:C23H25ClN6O3Purezza:98.07% - 98.78%Colore e forma:SolidPeso molecolare:468.94Ref: TM-T1918
1mg46,00€2mg59,00€5mg96,00€10mg155,00€25mg250,00€50mg358,00€100mg537,00€1mL*10mM (DMSO)96,00€GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purezza:98.89% - >99.99%Colore e forma:SolidPeso molecolare:532.57NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormula:C27H29N5OPurezza:98.7% - 99.86%Colore e forma:SolidPeso molecolare:439.55NVP-ADW742
CAS:NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFormula:C28H31N5OPurezza:96.14% - 98.70%Colore e forma:SolidPeso molecolare:453.58NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Formula:C16H14BrNO5SPurezza:99.64%Colore e forma:SolidPeso molecolare:412.26Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formula:C42H70O12Purezza:98% - 99.65%Colore e forma:SolidPeso molecolare:767.00Ref: TM-T6S1487
1mg107,00€5mg251,00€10mg404,00€25mg665,00€50mg888,00€100mg1.251,00€1mL*10mM (DMSO)341,00€Insulin(cattle)
CAS:Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.Formula:C254H377N65O75S6Purezza:98%Colore e forma:SolidPeso molecolare:5733.49NBI-31772 hydrate
NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.Formula:C17H13NO8Colore e forma:SolidPeso molecolare:372.82Linsitinib
CAS:OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.Formula:C26H23N5OPurezza:99.71% - ≥95%Colore e forma:SolidPeso molecolare:421.49AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurezza:99.13%Colore e forma:SolidPeso molecolare:448.95AG1024
CAS:AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formula:C14H13BrN2OPurezza:98% - 99.37%Colore e forma:SolidPeso molecolare:305.17MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€BRD7552
CAS:BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.Formula:C33H33N3O15Purezza:>99.99% - ≥98%Colore e forma:SolidPeso molecolare:711.63Sari 59-801
CAS:Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Formula:C18H23N3O2Purezza:99.92%Colore e forma:SolidPeso molecolare:313.39Ref: TM-T34532
1mg37,00€5mg113,00€10mg170,00€25mg278,00€50mg386,00€100mg520,00€1mL*10mM (DMSO)114,00€Glymidine
CAS:Glycodiazine, a sulfadiazine derivative, reduces blood sugar by boosting insulin release and sensitivity.Formula:C13H15N3O4SColore e forma:SolidPeso molecolare:309.34GIP (1-30) amide, porcine acetate
GIP (1-30) amide, porcine is a GIP receptor agonist that stimulates insulin and mildly inhibits gastric acid.Formula:C164H249N41O49SPurezza:98.50%Colore e forma:SolidPeso molecolare:3611.04Glymidine sodium
CAS:Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.Formula:C13H14N3NaO4SPurezza:98.19%Colore e forma:SolidPeso molecolare:331.32PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Formula:C18H17Cl2N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:378.25Insulin (human)
CAS:Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood.Formula:C257H383N65O77S6Purezza:97.32% - 99.99%Colore e forma:SolidPeso molecolare:5807.57MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Formula:C19H18N2O4SPurezza:98.11% - 99.53%Colore e forma:SolidPeso molecolare:370.42Ref: TM-T2607
1mg35,00€2mg50,00€5mg77,00€10mg99,00€25mg154,00€50mg197,00€100mg350,00€1mL*10mM (DMSO)82,00€MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:314.38AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purezza:97.07% - 99.75%Colore e forma:SolidPeso molecolare:485.58Ceritinib dihydrochloride
CAS:Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Formula:C28H38Cl3N5O3SPurezza:99.85% - 99.99%Colore e forma:SolidPeso molecolare:631.06Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formula:C28H36ClN5O3SPurezza:98.52% - 99.77%Colore e forma:SolidPeso molecolare:558.14Picropodophyllin
CAS:Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Formula:C22H22O8Purezza:98.38% - 99.83%Colore e forma:SolidPeso molecolare:414.41Ref: TM-T6943
5mg64,00€10mg88,00€25mg170,00€50mg316,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)69,00€BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFormula:C25H26ClN5O3Purezza:99.02%Colore e forma:SolidPeso molecolare:479.96Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formula:C20H19N3O4Purezza:98.54%Colore e forma:SolidPeso molecolare:365.38Ref: TM-T11654
1mg42,00€5mg88,00€10mg124,00€25mg197,00€50mg293,00€100mg434,00€200mg622,00€1mL*10mM (DMSO)93,00€GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Formula:C44H47F2N9O5SPurezza:98.2% - 99.76%Colore e forma:SolidPeso molecolare:851.96Figitumumab
CAS:Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.Purezza:95%Colore e forma:LiquidAnti-IGFBP2 Antibody (M14)
Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.Colore e forma:Odour LiquidDusigitumab
CAS:Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.
Purezza:95% - 95%Colore e forma:LiquidVeligrotug
CAS:Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.Purezza:95% - 96.7% (SDS-PAGE); 99.8% (SEC-HPLC)Colore e forma:LiquidS961
CAS:S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.Formula:C211H297N55O71S2Purezza:98%Colore e forma:SolidPeso molecolare:4804.13BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formula:C23H24FN9OPurezza:99.69% - 99.94%Colore e forma:SolidPeso molecolare:461.49Ref: TM-T2349
1mg49,00€2mg70,00€5mg96,00€10mg166,00€25mg328,00€50mg537,00€100mg772,00€1mL*10mM (DMSO)116,00€AZ12253801
CAS:AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.Formula:C21H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:402.45BM-131246
CAS:BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.Formula:C22H20N2O4SPurezza:>99.99%Colore e forma:SolidPeso molecolare:408.47KU14R
CAS:KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.Formula:C13H14N2OPurezza:98%Colore e forma:White SolidPeso molecolare:214.26IMP2-IN-2
CAS:IMP2-IN-2: potent, selective IMP2 inhibitor; IC50s: 120.9 μM (RNA_A), 236.7 μM (RNA_B); used in cancer research.Formula:C22H19F3N2O3SColore e forma:SolidPeso molecolare:448.46H-1356
CAS:H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.Formula:C55H88N14O15S2Colore e forma:SolidPeso molecolare:1249.5D-(+)-Sorbose
CAS:D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.Formula:C6H12O6Colore e forma:SolidPeso molecolare:180.16Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Formula:C8H5NO2S2Purezza:99.77%Colore e forma:SolidPeso molecolare:211.26Ref: TM-T71812
1mg90,00€5mg215,00€10mg313,00€25mg537,00€50mg713,00€100mg982,00€200mg1.333,00€1mL*10mM (DMSO)236,00€NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formula:C16H14BrNO5SPurezza:98.06% - 99.72%Colore e forma:SolidPeso molecolare:412.26I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Formula:C17H12INO5Purezza:98.8%Colore e forma:SolidPeso molecolare:437.19Ref: TM-T11593
1mg56,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)131,00€BMS-695735
CAS:BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.Formula:C26H31ClFN7OColore e forma:SolidPeso molecolare:512.02
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