Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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Resveratrol analog 1
CAS:Resveratrol analog 1 is a natural product analog of resveratrol, which has more significant anti-leukemic activity than resveratrol.Formula:C14H11FO2Purezza:98.42%Colore e forma:SolidPeso molecolare:230.23Rupatadine
CAS:Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors ,allergic and anti-inflammatory.Formula:C26H26ClN3Purezza:99.87%Colore e forma:SolidPeso molecolare:415.96Gefitinib-d8
CAS:Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.Formula:C22H24ClFN4O3Purezza:98%Colore e forma:SolidPeso molecolare:454.95Brivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormula:C19H19FN4O3Purezza:98.87%Colore e forma:SolidPeso molecolare:370.38Ref: TM-T6036
1mg47,00€5mg88,00€10mg144,00€25mg259,00€50mg375,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€Heparin Lithium
CAS:Heparin Lithium salt is an anticoagulant that reversibly binds to ATIII and enhances its inhibitory effect on coagulation factor(thrombin and factor Xa).Formula:C14H25NO20S3Colore e forma:SolidPeso molecolare:623.01321Afatinib D6
CAS:Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.Formula:C24H25ClFN5O3Colore e forma:SolidPeso molecolare:491.98KN-93 hydrochloride
CAS:KN-93 hydrochloride is a reversible, competitive CaMKII inhibitor inducing reversible G1 arrest, supporting cell cycle and signaling pathway studies.Formula:C26H30Cl2N2O4SPurezza:99.99%Colore e forma:SolidPeso molecolare:537.5Ref: TM-T21557
1mgPrezzo su richiesta5mg116,00€10mg159,00€25mg305,00€50mg376,00€1mL*10mM (DMSO)137,00€Regorafenib-d3
CAS:Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.Formula:C21H15ClF4N4O3Purezza:98%Colore e forma:SolidPeso molecolare:485.83LY2510924
CAS:LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Formula:C62H88N14O10Colore e forma:SolidPeso molecolare:1189.45Loperamide-d6 hydrochloride
CAS:Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.Formula:C29H34Cl2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:519.54Pemetrexed disodium heptahydrate
CAS:Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits TS, DHFR and GARFT, inhibits precursor purine and pyrimidine nucleotides.Formula:C20H33N5Na2O13Purezza:99.783%Colore e forma:SolidPeso molecolare:597.49Rosuvastatin D3 Sodium
CAS:Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).Formula:C22H24D3FN3NaO6SPurezza:98%Colore e forma:SolidPeso molecolare:506.54Dexamethasone-d5
CAS:<p>Dexamethasone-d5 is a deuterated compound of Dexamethasone.</p>Formula:C22H24D5FO5Colore e forma:SolidPeso molecolare:397.49Pyrazinamide-d3
CAS:Pyrazinamide-d3 is a deuterated compound of Pyrazinamide. Pyrazinamide has a CAS number of 98-96-4. Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.Formula:C5D3H2N3OColore e forma:SolidPeso molecolare:126.13Thiacloprid
CAS:Thiacloprid: insecticide targeting insect nAChRs, IC50 - Drosophila: 2.7 nM, Mouse α4β2 nAChRs: 860 nM.Formula:C10H9ClN4SPurezza:98.66% - 99.95%Colore e forma:Yellowish Crystalline PowderPeso molecolare:252.72Isorhapontigenin
CAS:Isorhapontigenin: a methoxylated stilbenoid isomer of rhapontigenin, similar to resveratrol, present in Gnetum spp. and Aiphanes aculeata seeds.Formula:C15H14O4Purezza:98.49% - 99.85%Colore e forma:Off White Crystals PowerPeso molecolare:258.27CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formula:C34H37N5O4Purezza:97.69% - 97.88%Colore e forma:SolidPeso molecolare:579.69Valproic Acid
CAS:Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels.Formula:C8H16O2Purezza:97.78% - 99%Colore e forma:Colourless To Pale Yellow Liquid ViscousPeso molecolare:144.21Ginkgolide K
CAS:Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.Formula:C20H22O9Purezza:99.44% - 99.72%Colore e forma:SolidPeso molecolare:406.38Nur77 modulator 1
CAS:Nur77 modulator 1: binds at 3.58 μM, boosts expression, alters location, triggers ER stress/autophagy, induces apoptosis, and fights hepatoma.Formula:C28H25N5O2SPurezza:99.62%Colore e forma:SolidPeso molecolare:495.6Ref: TM-T40130
1mg64,00€5mg140,00€10mg226,00€25mg373,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)153,00€Ginsenoside F2
CAS:Ginsenoside F2 halts breast CSCs growth, induces apoptosis via intrinsic pathway and impairs mitochondria.Formula:C42H72O13Purezza:99.04% - 99.3%Colore e forma:SolidPeso molecolare:785.01Ref: TM-T3916
1mg35,00€5mg69,00€10mg88,00€25mg144,00€50mg205,00€100mg303,00€500mg735,00€1mL*10mM (DMSO)97,00€Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purezza:97.07% - 99.56%Colore e forma:SolidPeso molecolare:414.46Ref: TM-T1849
1mg38,00€2mg49,00€5mg81,00€10mg95,00€25mg166,00€50mg259,00€100mg406,00€200mg625,00€1mL*10mM (DMSO)88,00€Clematichinenoside AR
CAS:Clematichinenoside AR is anti-inflammatory, immunosuppressive, and combats arthritis via PI3K/Akt and TNF-α pathways.Formula:C82H134O43Purezza:99.04% - 99.69%Colore e forma:SolidPeso molecolare:1807.92Tanespimycin
CAS:Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!Formula:C31H43N3O8Purezza:98.24% - 99.83%Colore e forma:Dark Purple SolidPeso molecolare:585.69Pirarubicin HCl
CAS:Pirarubicin HCl, a less cardiotoxic doxorubicin analogue, hinders DNA replication and repairs by intercalating into DNA and inhibiting topoisomerase II.Formula:C32H38ClNO12Colore e forma:SolidPeso molecolare:664.1BAY 11-7082
CAS:BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM).Formula:C10H9NO2SPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:207.25Ref: TM-T1902
5mg50,00€10mg57,00€25mg96,00€50mg170,00€100mg265,00€200mg399,00€500mg662,00€1mL*10mM (DMSO)52,00€TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purezza:99.17% - 99.53%Colore e forma:White Solid PowderPeso molecolare:166.22Selenomethionine
CAS:DL-Selenomethionine (SeMet) is a selenium analog of methionine, substituting sulfur with selenium, and can replace methionine in proteins.Formula:C5H11NO2SePurezza:98% - 99.95%Colore e forma:Transparent Hexagonal Sheets Or Plates; Metallic Luster Of Crystals SolidPeso molecolare:196.11Dimethyl fumarate
CAS:Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.Formula:C6H8O4Purezza:90.51% - >99.99%Colore e forma:White To Off-White Powder White Crystalline PowderPeso molecolare:144.13JMS-17-2 hydrochloride
CAS:JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.Formula:C25H27Cl2N3OColore e forma:SolidPeso molecolare:456.41Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Formula:C14H16F3N7Purezza:98.01% - 99.97%Colore e forma:SolidPeso molecolare:339.32Ref: TM-T6031
1mg47,00€2mg60,00€5mg119,00€10mg187,00€25mg376,00€50mg562,00€100mg802,00€500mg1.644,00€1mL*10mM (DMSO)96,00€Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFormula:C14H11ClN6O3Purezza:99.25% - 99.41%Colore e forma:SolidPeso molecolare:346.73Ref: TM-T4219
2mg42,00€5mg62,00€10mg93,00€25mg169,00€50mg227,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)70,00€STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formula:C19H10N2O3Purezza:97.14% - 98.8%Colore e forma:SolidPeso molecolare:314.29Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Formula:C22H28N2O4Purezza:96.83% - 99.93%Colore e forma:SolidPeso molecolare:384.47ABT-751
CAS:ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.Formula:C18H17N3O4SPurezza:98.84% - 99.50%Colore e forma:SolidPeso molecolare:371.41KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormula:C19H17Cl2N3O2SPurezza:98.86%Colore e forma:SolidPeso molecolare:422.33SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurezza:98.84%Colore e forma:SolidPeso molecolare:469.56L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurezza:≥95%Colore e forma:SolidPeso molecolare:347.8CHIR-99021
CAS:View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.Formula:C22H18Cl2N8Purezza:97.94% - ≥95%Colore e forma:SolidPeso molecolare:465.34Ref: TM-T2310
2mg43,00€5mg64,00€10mg96,00€25mg160,00€50mg254,00€100mg404,00€200mg603,00€500mg938,00€1mL*10mM (DMSO)70,00€Sinomenine
CAS:<p>Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.</p>Formula:C19H23NO4Purezza:99.02% - 99.73%Colore e forma:White PowderPeso molecolare:329.39Bergapten
CAS:Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.Formula:C12H8O4Purezza:99.48% - ≥95%Colore e forma:Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Peso molecolare:216.19IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formula:C22H15Br2N3O4Purezza:98.92% - ≥95%Colore e forma:SolidPeso molecolare:545.18Pinocembrin
CAS:Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.Formula:C15H12O4Purezza:99.61% - >99.99%Colore e forma:SolidPeso molecolare:256.25MW-150 dihydrochloride dihydrate
CAS:MW-150: selective CNS-penetrant p38α MAPK inhibitor, orally active, Ki 101 nM, blocks MK2 phosphorylation in glia.Formula:C24H29Cl2N5O2Colore e forma:SolidPeso molecolare:490.43Cediranib
CAS:Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.Formula:C25H27FN4O3Purezza:97.21% - 99.94%Colore e forma:SolidPeso molecolare:450.51Ref: TM-T2500
2mg42,00€5mg63,00€10mg92,00€25mg136,00€50mg177,00€100mg254,00€200mg462,00€500mg742,00€1mL*10mM (DMSO)69,00€Tubastatin A Hydrochloride
CAS:<p>Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).</p>Formula:C20H21N3O2·HClPurezza:97.24% - 99.15%Colore e forma:SolidPeso molecolare:371.86Quizartinib
CAS:Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.Formula:C29H32N6O4SPurezza:98% - 99.42%Colore e forma:SolidPeso molecolare:560.67Ref: TM-T2066
5mg58,00€10mg79,00€25mg97,00€50mg127,00€100mg202,00€200mg300,00€500mg507,00€1mL*10mM (DMSO)71,00€AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formula:C21H21N3O2SPurezza:97.24% - 99.83%Colore e forma:SolidPeso molecolare:379.48U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Formula:C18H16N6S2·C2H6OPurezza:99.72% - 99.88%Colore e forma:SolidPeso molecolare:426.6
