Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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N-Benzylpalmitamide
CAS:N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for theFormula:C23H39NOPurezza:97.08% - 99.77%Colore e forma:SolidPeso molecolare:345.56Parthenolide
CAS:Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB and HDAC1 inhibitor with anti-inflammatory effect. Cost-effective and quality-assured.Formula:C15H20O3Purezza:98.19% - 99.46%Colore e forma:White To Pale Yellow Crystalline PowderPeso molecolare:248.32Capivasertib
CAS:<p>Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity.</p>Formula:C21H25ClN6O2Purezza:97.59% - 99.6%Colore e forma:SolidPeso molecolare:428.92PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurezza:99.13% - 99.83%Colore e forma:SolidPeso molecolare:369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€Everolimus
CAS:<p>Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.</p>Formula:C53H83NO14Purezza:97.76% - 99.78%Colore e forma:Off-White To Light Yellow PowdPeso molecolare:958.22Sophocarpine
CAS:Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formula:C15H22N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:246.35Dinoprost tromethamine salt
CAS:Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.Formula:C24H45NO8Purezza:99.73%Colore e forma:Natural Form Crystals SolidPeso molecolare:475.62Idarubicin
CAS:Idarubicin, a potent oral anthracycline, halts DNA/RNA replication and synthesis, damages DNA, and inhibits microbial growth.Formula:C26H27NO9Colore e forma:SolidPeso molecolare:497.49Sanguinarine
CAS:Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.Formula:C20H14NO4Purezza:99.04% - 99.76%Colore e forma:SolidPeso molecolare:332.33Lys05
CAS:Lys05, a potent autophagy inhibitor, outperforms HCQ in cancer treatment, showing promise for drug development.Formula:C23H26Cl5N5Purezza:99.13% - 99.55%Colore e forma:SolidPeso molecolare:549.75Polydatin
CAS:Polydatin, a resveratrol glycoside from Polygonum cuspidatum, inhibits platelet aggregation, alters lipid ratios, and modulates cell functions.Formula:C20H22O8Purezza:97.2% - 98.94%Colore e forma:White Fine PowderPeso molecolare:390.38Rac-Belinostat
CAS:<p>Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.</p>Formula:C15H14N2O4SPurezza:99.67% - 99.96%Colore e forma:SolidPeso molecolare:318.35Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purezza:97.03% - 99.90%Colore e forma:SolidPeso molecolare:317.34Elubrixin HCl
CAS:Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Formula:C17H18Cl3FN4O4SColore e forma:SolidPeso molecolare:499.77SNX2112
CAS:SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.Formula:C23H27F3N4O3Purezza:98.75% - 99.46%Colore e forma:SolidPeso molecolare:464.48Ref: TM-T6305
1mg38,00€5mg80,00€10mg120,00€25mg216,00€50mg334,00€100mg477,00€200mg662,00€1mL*10mM (DMSO)81,00€Mavorixafor trihydrochloride
CAS:Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.Formula:C21H30Cl3N5Purezza:98.00%Colore e forma:SolidPeso molecolare:458.86Enalaprilat Dihydrate
CAS:Enalaprilat Dihydrate (MK-422 Dihydrate) （IC50=1.94 nM） is a potent angiotensin-converting enzyme (ACE) inhibitor.Formula:C18H24N2O5·2H2OPurezza:99.46% - 99.78%Colore e forma:SolidPeso molecolare:348.4Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurezza:98% - 99.45%Colore e forma:SolidPeso molecolare:393.49Ref: TM-T1825
1mg38,00€2mg49,00€5mg70,00€10mg88,00€25mg164,00€50mg224,00€100mg393,00€1mL*10mM (DMSO)70,00€MLN9708 analogues
CAS:MLN2238 inhibits 20S proteasome's β5 site (Ki50=0.93 nM, IC50=3.4 nM), active form of Ixazomib Citrate in solutions/plasma.Formula:C20H23BCl2N2O9Purezza:98.24% - 99.23%Colore e forma:SolidPeso molecolare:517.12Ref: TM-T2016
5mg50,00€10mg66,00€25mg96,00€50mg131,00€100mg215,00€200mg319,00€500mg535,00€1mL*10mM (DMSO)52,00€Tepotinib hydrochloride(1 : x)
CAS:Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14Formula:C29H29ClN6O2Purezza:99.81%Colore e forma:SolidPeso molecolare:529.04Regorafenib mesylate
CAS:Regorafenib mesylate is an oral multi-kinase inhibitor targeting VEGFR, PDGFRβ, Kit, RET, Raf-1 with strong anti-tumor and anti-angiogenic effects.Formula:C22H19ClF4N4O6SColore e forma:SolidPeso molecolare:578.92Aliskiren hydrochloride
CAS:Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is a selective, orally active, renin inhibitor (IC50: 1.5 nM). Cachexia.Formula:C30H54ClN3O6Colore e forma:SolidPeso molecolare:588.23Atorvastatin hemicalcium trihydrate
CAS:Atorvastatin hemicalcium trihydrate, an oral HMG-CoA reductase inhibitor, lowers blood lipids and inhibits SV-SMC with IC50s: 0.39/2.39 μM.Formula:C33H35FN2O5Ca·3H2OColore e forma:SolidPeso molecolare:632.73Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purezza:99% - 99.98%Colore e forma:SolidPeso molecolare:392.49Ref: TM-T2588
1mg38,00€2mgPrezzo su richiesta5mg81,00€10mg127,00€25mg205,00€50mg304,00€100mg439,00€200mgPrezzo su richiesta1mL*10mM (DMSO)88,00€Nitroprusside disodium dihydrate
CAS:Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.Formula:C5H4FeN6Na2O3Purezza:98%Colore e forma:Bright RedPeso molecolare:297.95Sofalcone
CAS:Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.Formula:C27H30O6Purezza:97.55%Colore e forma:SolidPeso molecolare:450.52PI3Kδ-IN-15
CAS:CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.Formula:C21H16FN7OPurezza:99.61%Colore e forma:SolidPeso molecolare:401.4TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purezza:99.55% - 99.94%Colore e forma:SolidPeso molecolare:351.32Ref: TM-T4645
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg235,00€100mg329,00€200mg464,00€1mL*10mM (DMSO)71,00€XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Formula:C23H22FN3O4SPurezza:99.39% - 99.53%Colore e forma:SolidPeso molecolare:455.5PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Formula:C17H13Br2N5OS·HBrPurezza:99.91%Colore e forma:SolidPeso molecolare:576.1Ref: TM-T6178
1mg37,00€5mg78,00€10mg124,00€25mg265,00€50mg465,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)89,00€CCT128930 hydrochloride
CAS:CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.Formula:C18H21Cl2N5Purezza:98.55%Colore e forma:SolidPeso molecolare:378.3Ref: TM-T6303L
1mg52,00€5mg97,00€10mg157,00€25mg254,00€50mg379,00€100mg552,00€200mg815,00€1mL*10mM (DMSO)110,00€Pinosylvin
CAS:Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.Formula:C14H12O2Purezza:99.89% - 99.91%Colore e forma:SolidPeso molecolare:212.24U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Formula:C18H16N6S2·C2H6OPurezza:99.72% - 99.88%Colore e forma:SolidPeso molecolare:426.6MW-150 dihydrochloride dihydrate
CAS:MW-150: selective CNS-penetrant p38α MAPK inhibitor, orally active, Ki 101 nM, blocks MK2 phosphorylation in glia.Formula:C24H29Cl2N5O2Colore e forma:SolidPeso molecolare:490.43Pinocembrin
CAS:Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.Formula:C15H12O4Purezza:99.61% - >99.99%Colore e forma:SolidPeso molecolare:256.25IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formula:C22H15Br2N3O4Purezza:98.92% - ≥95%Colore e forma:SolidPeso molecolare:545.18JMS-17-2 hydrochloride
CAS:JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.Formula:C25H27Cl2N3OColore e forma:SolidPeso molecolare:456.41TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purezza:99.17% - 99.53%Colore e forma:White Solid PowderPeso molecolare:166.22Ginsenoside F2
CAS:Ginsenoside F2 halts breast CSCs growth, induces apoptosis via intrinsic pathway and impairs mitochondria.Formula:C42H72O13Purezza:99.04% - 99.3%Colore e forma:SolidPeso molecolare:785.01Ref: TM-T3916
1mg35,00€5mg69,00€10mg88,00€25mg144,00€50mg205,00€100mg303,00€500mg735,00€1mL*10mM (DMSO)97,00€Thiacloprid
CAS:Thiacloprid: insecticide targeting insect nAChRs, IC50 - Drosophila: 2.7 nM, Mouse α4β2 nAChRs: 860 nM.Formula:C10H9ClN4SPurezza:98.66% - 99.95%Colore e forma:Yellowish Crystalline PowderPeso molecolare:252.72PFE-360
CAS:<p>PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).</p>Formula:C16H16N6OPurezza:98.14% - 99.73%Colore e forma:SolidPeso molecolare:308.34Mocetinostat
CAS:Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.Formula:C23H20N6OPurezza:99% - 99.21%Colore e forma:SolidPeso molecolare:396.44Sertaconazole
CAS:Sertaconazole is a broad-spectrum antifungal.Formula:C20H15Cl3N2OSPurezza:99.483%Colore e forma:SolidPeso molecolare:437.77Ref: TM-T50005
5mg58,00€10mg82,00€25mg126,00€50mg182,00€100mg273,00€200mg409,00€1mL*10mM (DMSO)84,00€NAcM-OPT HCl(2089293-61-6 free base)
CAS:NAcM-OPT HCL: Oral DCN1 inhibitor targeting N-Acetyl-UBE2M & DCN1, IC50=79 nM.Formula:C23H30Cl3N3OPurezza:99.43%Colore e forma:SolidPeso molecolare:470.86Ref: TM-T9140
2mg38,00€5mg51,00€10mg92,00€25mg148,00€50mg240,00€100mg391,00€500mg929,00€1mL*10mM (DMSO)87,00€AZD-8055
CAS:<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Formula:C25H31N5O4Purezza:98% - 99.69%Colore e forma:SolidPeso molecolare:465.54ARRY-797
CAS:<p>ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.</p>Formula:C22H26F2N4O2Purezza:98.97% - 99.81%Colore e forma:SolidPeso molecolare:416.46Sulfosuccinimidyl oleate sodium
CAS:Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits fatty acid transport into cells.Cost-effective and quality-assured.Formula:C22H36NNaO7SPurezza:96.53%Colore e forma:SolidPeso molecolare:481.58Ref: TM-T13036L
1mg38,00€5mg72,00€10mg117,00€25mg187,00€50mg299,00€100mg472,00€200mg607,00€500mg938,00€Lamotrigine hydrate
CAS:Lamotrigine hydrate: oral anticonvulsant, blocks Na+ channels, stabilizes neurons, inhibits glutamate, treats epilepsy, focal seizure.Formula:C9H9Cl2N5OColore e forma:SolidPeso molecolare:274.11Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.61%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Formula:C15H10O7Purezza:96.29% - 98.05%Colore e forma:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Peso molecolare:302.24
