Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1491 prodotti di "Autofagia"
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Dacinostat
CAS:LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.Formula:C22H25N3O3Purezza:95.28% - 97.88%Colore e forma:SolidPeso molecolare:379.45Ref: TM-T2454
1mg49,00€2mg67,00€5mg110,00€10mg180,00€25mg323,00€50mg487,00€100mg705,00€500mg1.444,00€1mL*10mM (DMSO)110,00€PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Formula:C26H22N4O3Purezza:98.80% - ≥95%Colore e forma:SolidPeso molecolare:438.48Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)
Myristoylated autocamtide-2-related inhibitory peptide acetate is a cell-permeable CaM kinase II inhibitor.Formula:C80H146N22O22Purezza:97.03%Colore e forma:SolidPeso molecolare:1768.15Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formula:C21H28O2Purezza:99.4% - 99.8%Colore e forma:Light Yellow PowderPeso molecolare:312.45Ref: TM-T5574
1mg35,00€5mg52,00€10mg87,00€25mg160,00€50mg216,00€100mg305,00€200mg455,00€1mL*10mM (DMSO)58,00€SR-18292
CAS:SR-18292 inhibits PGC-1α, enhances acetylation, lowers gluconeogenesis, and cuts hepatic glucose production.Formula:C23H30N2O2Purezza:99.16% - 99.91%Colore e forma:SolidPeso molecolare:366.5Ref: TM-T4353
2mg40,00€5mg60,00€10mg87,00€25mg180,00€50mg283,00€100mg449,00€500mg938,00€1mL*10mM (DMSO)71,00€SB 242235
CAS:SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.Formula:C19H20FN5OPurezza:99.13% - 99.68%Colore e forma:SolidPeso molecolare:353.39Temsirolimus
CAS:Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.Formula:C56H87NO16Purezza:97.76% - >99.99%Colore e forma:White Crystalline PowderPeso molecolare:1030.29CA77.1
CAS:CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).Formula:C16H12ClN3OPurezza:99.50%Colore e forma:SolidPeso molecolare:297.74TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formula:C27H46ClNO2Purezza:99.75% - ≥95%Colore e forma:SolidPeso molecolare:452.11Triptonide
CAS:Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.Formula:C20H22O6Purezza:99.11% - 99.64%Colore e forma:White Crystalline PowderPeso molecolare:358.39Ref: TM-T5S1058
1mg56,00€2mgPrezzo su richiesta5mg114,00€10mg166,00€25mg283,00€50mg432,00€100mg628,00€200mg879,00€1mL*10mM (DMSO)140,00€Leonurine hydrochloride
CAS:Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt.Formula:C14H22ClN3O5Purezza:99.07%Colore e forma:SolidPeso molecolare:347.79Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Formula:C27H30O14Purezza:98.11% - 98.58%Colore e forma:SolidPeso molecolare:578.52palovarotene
CAS:<p>Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).</p>Formula:C27H30N2O2Purezza:97.88% - 98.05%Colore e forma:SolidPeso molecolare:414.54C646
CAS:<p>C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).</p>Formula:C24H19N3O6Purezza:98% - 99.21%Colore e forma:SolidPeso molecolare:445.42Ref: TM-T2452
2mg48,00€5mg69,00€10mg97,00€25mg195,00€50mg380,00€100mg562,00€500mg1.206,00€1mL*10mM (DMSO)69,00€SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purezza:99.42% - 99.81%Colore e forma:SolidPeso molecolare:368.4Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formula:C19H12ClN3O2Purezza:98% - 99.90%Colore e forma:SolidPeso molecolare:349.77Ref: TM-T2259
1mg40,00€2mg51,00€5mg85,00€10mg125,00€25mg207,00€50mg329,00€100mg520,00€500mg1.111,00€1mL*10mM (DMSO)93,00€Scriptaid
CAS:Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.Formula:C18H18N2O4Purezza:96.74% - 99.45%Colore e forma:SolidPeso molecolare:326.35Ref: TM-T6980
5mg67,00€10mg92,00€25mg193,00€50mg358,00€100mg537,00€500mg1.134,00€1mL*10mM (DMSO)74,00€4E1rcat
CAS:4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.Formula:C28H18N2O6Purezza:99.47%Colore e forma:SolidPeso molecolare:478.45Hemin
CAS:Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.Formula:C34H32ClFeN4O4Purezza:97.169% - 99.59%Colore e forma:Dark Purple Crystalline PowderPeso molecolare:651.94β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purezza:99.76% - 99.88%Colore e forma:SolidPeso molecolare:242.27DAPT
CAS:DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.Formula:C23H26F2N2O4Purezza:98.06% - 99.81%Colore e forma:White SolidPeso molecolare:432.46Ref: TM-T6202
2mg40,00€5mg58,00€10mg88,00€25mg165,00€50mg279,00€100mg378,00€200mg517,00€1mL*10mM (DMSO)59,00€Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purezza:99.12% - 99.76%Colore e forma:SolidPeso molecolare:1109.29SB225002
CAS:SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Formula:C13H10BrN3O4Purezza:98.16% - 99.85%Colore e forma:SolidPeso molecolare:352.14Ref: TM-T1955
5mg50,00€10mg66,00€25mg127,00€50mg225,00€100mg404,00€200mg617,00€500mg938,00€1mL*10mM (DMSO)52,00€FC131 TFA (606968-52-9 free base)
CAS:FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hivFormula:C38H48F3N11O8Purezza:99.39% - 99.67%Colore e forma:SolidPeso molecolare:843.85ATI-2341 acetate(1337878-62-2 free base)
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.Formula:C106H182N26O27S2Purezza:97.14%Colore e forma:SolidPeso molecolare:2316.87MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formula:C16H16N6Purezza:98.31% - 98.94%Colore e forma:SolidPeso molecolare:292.34Acacetin
CAS:Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidantFormula:C16H12O5Purezza:96.26% - ≥95%Colore e forma:Pale-Yellow NeedlesPeso molecolare:284.26Danirixin
CAS:<p>Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).</p>Formula:C19H21ClFN3O4SPurezza:99.78% - >99.99%Colore e forma:SolidPeso molecolare:441.9Navarixin
CAS:Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFormula:C21H23N3O5Purezza:98% - 99.51%Colore e forma:SolidPeso molecolare:397.42Ref: TM-T7130
1mg40,00€5mg85,00€10mg120,00€25mg210,00€50mg316,00€100mg467,00€500mg1.026,00€1mL*10mM (DMSO)93,00€PD 169316
CAS:PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Formula:C20H13FN4O2Purezza:98.65%Colore e forma:SolidPeso molecolare:360.34AMD 3465 hexahydrobromide
CAS:AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Formula:C24H44Br6N6Purezza:99.39%Colore e forma:SolidPeso molecolare:896.07SB-265610
CAS:SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Formula:C14H9BrN6OPurezza:99.5%Colore e forma:SolidPeso molecolare:357.16Ref: TM-T16850
1mg56,00€5mg119,00€10mg187,00€25mg376,00€50mg560,00€100mg800,00€500mg1.644,00€1mL*10mM (DMSO)131,00€ML339
CAS:<p>ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.</p>Formula:C26H32ClN3O5Purezza:99.9%Colore e forma:SolidPeso molecolare:502AMD-070 hydrochloride
CAS:AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Formula:C21H28ClN5Purezza:98.38% - 98.57%Colore e forma:SolidPeso molecolare:385.93CTCE 9908 acetate
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.Formula:C88H151N27O25Purezza:98.47%Colore e forma:SolidPeso molecolare:1987.31MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Formula:C16H24N2O4Purezza:98.43%Colore e forma:SolidPeso molecolare:308.37WZ811
CAS:WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).Formula:C18H18N4Purezza:99.42% - ≥95%Colore e forma:SolidPeso molecolare:290.36USL311
CAS:USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Formula:C24H34N6OPurezza:98.46% - 99.56%Colore e forma:SolidPeso molecolare:422.57Ref: TM-T17208
1mg42,00€5mg88,00€10mg127,00€25mg250,00€50mg393,00€100mg628,00€500mg1.304,00€1mL*10mM (DMSO)87,00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purezza:99.21%Colore e forma:SolidPeso molecolare:531.13Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purezza:98% - 99.5%Colore e forma:SolidPeso molecolare:855.02JMS-17-2
CAS:JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Formula:C25H26ClN3OPurezza:98.7% - 99.44%Colore e forma:SolidPeso molecolare:419.95Ref: TM-T5849
1mg38,00€5mg82,00€10mg124,00€25mg210,00€50mg328,00€100mg485,00€200mg702,00€1mL*10mM (DMSO)92,00€TC14012 acetate
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM.Formula:C92H144N34O21S2Purezza:98.33% - 99.71%Colore e forma:SolidPeso molecolare:2126.47MSX-130
CAS:MSX-130 is CXCR4 Antagonist.Formula:C36H26N4Purezza:99.19%Colore e forma:SolidPeso molecolare:514.62SRT3109
CAS:SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Formula:C18H23F2N5O4S2Purezza:99.65% - 99.92%Colore e forma:SolidPeso molecolare:475.53Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formula:C28H54N8Purezza:99.17% - >99.99%Colore e forma:SolidPeso molecolare:502.78AZD-5069
CAS:AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Formula:C18H22F2N4O5S2Purezza:98.38% - 98.63%Colore e forma:SolidPeso molecolare:476.52Ref: TM-T7681
1mg37,00€2mg49,00€5mg70,00€10mg103,00€25mg202,00€50mg311,00€100mg472,00€200mgPrezzo su richiesta1mL*10mM (DMSO)78,00€Plerixafor octahydrochloride
CAS:Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Formula:C28H62Cl8N8Purezza:98.01% - 99.79%Colore e forma:SolidPeso molecolare:794.46SX-682
CAS:SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Formula:C19H14BF4N3O4SPurezza:98.19% - 99.61%Colore e forma:SolidPeso molecolare:467.2Isobavachalcone
CAS:<p>Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in</p>Formula:C20H20O4Purezza:98% - 99.76%Colore e forma:SolidPeso molecolare:324.37HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purezza:99.59%Colore e forma:SolidPeso molecolare:377.83Ref: TM-T7196
2mg35,00€5mg55,00€10mg89,00€25mg161,00€50mg250,00€100mg360,00€200mg512,00€1mL*10mM (DMSO)62,00€
