Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1490 prodotti di "Autofagia"
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RITA
CAS:RITA (NSC-652287) forms DNA-DNA/protein cross-links without DNA breaks; disrupts p53/Mdm2 like nutlin-3.Formula:C14H12O3S2Purezza:98.49% - 99.55%Colore e forma:SolidPeso molecolare:292.37Ref: TM-T1798
1mg35,00€5mg66,00€10mg96,00€25mg187,00€50mg279,00€100mg420,00€200mg607,00€1mL*10mM (DMSO)89,00€4EGI-1
CAS:4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).Formula:C18H12Cl2N4O4SPurezza:96.8% - 99.12%Colore e forma:SolidPeso molecolare:451.28Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purezza:97.79% - >99.99%Colore e forma:Yellow SolidPeso molecolare:384.24Ref: TM-T2399
5mg52,00€10mg64,00€25mg80,00€50mg96,00€100mg144,00€200mg225,00€500mg373,00€1mL*10mM (DMSO)52,00€CZC-25146 hydrochloride
CAS:<p>CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.</p>Formula:C22H26ClFN6O4SPurezza:98.76%Colore e forma:SolidPeso molecolare:525Danshensu
CAS:<p>Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.</p>Formula:C9H10O5Purezza:98.4% - 99.74%Colore e forma:SolidPeso molecolare:198.17SKF-96365 hydrochloride
CAS:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal YFormula:C22H27ClN2O3Purezza:99.47% - 99.92%Colore e forma:SolidPeso molecolare:402.91Ref: TM-T2170
5mg57,00€10mg86,00€25mg138,00€50mg243,00€100mg470,00€200mg717,00€500mg1.111,00€1mL*10mM (DMSO)63,00€Vitexin
CAS:Vitexin: antinociceptive, antispasmodic, antioxidant, affects CYP enzymes, may inhibit cancer metastasis, protects brain.Formula:C21H20O10Purezza:98.13% - 99.64%Colore e forma:Yellow PowderPeso molecolare:432.3810074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Formula:C18H12N4O3Purezza:99.51% - 99.94%Colore e forma:SolidPeso molecolare:332.31Ref: TM-T3686
2mg39,00€5mg59,00€10mg84,00€25mg135,00€50mg213,00€100mg375,00€200mg535,00€500mg853,00€1mL*10mM (DMSO)65,00€KN-93
CAS:KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.Formula:C26H29ClN2O4SPurezza:99.56% - 99.86%Colore e forma:White SolidPeso molecolare:501.04Ref: TM-T2697
1mg57,00€2mg79,00€5mg113,00€10mg155,00€25mg305,00€50mg378,00€100mg552,00€1mL*10mM (DMSO)127,00€Taxifolin
CAS:Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.Formula:C15H12O7Purezza:94.91% - 98.9%Colore e forma:Yellowish PowderPeso molecolare:304.25RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formula:C24H16F6N6OPurezza:99.56%Colore e forma:SolidPeso molecolare:518.41Ref: TM-T6296
1mg47,00€2mg63,00€5mg87,00€10mg147,00€25mg266,00€50mg435,00€100mg640,00€1mL*10mM (DMSO)99,00€D-glutamine
CAS:D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.Formula:C5H10N2O3Purezza:99.99%Colore e forma:White Or Off-White PowderPeso molecolare:146.14IU1
CAS:IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂，可以穿透细胞，IC50为 4.7 μM。Formula:C18H21FN2OPurezza:98% - 99.3%Colore e forma:SolidPeso molecolare:300.37PF-3845
CAS:PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.Formula:C24H23F3N4O2Purezza:99.54% - 99.58%Colore e forma:SolidPeso molecolare:456.46Eprenetapopt
CAS:Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.Formula:C10H17NO3Purezza:98.75% - 99.57%Colore e forma:SolidPeso molecolare:199.25Ref: TM-T4414
5mg73,00€10mg105,00€25mg207,00€50mg368,00€100mg652,00€500mg1.320,00€1mL*10mM (DMSO)81,00€ML-SA1
CAS:ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Formula:C22H22N2O3Purezza:99.34% - 99.71%Colore e forma:SolidPeso molecolare:362.42Ref: TM-T23004
2mg37,00€5mg51,00€10mg81,00€25mg150,00€50mg244,00€100mg364,00€200mg550,00€1mL*10mM (DMSO)58,00€Dynasore
CAS:Dynasore, a cell-permeable dynamin inhibitor, blocks GTPase of dynamin 1/2 and Drp1 (IC50: 15 μM) without affecting other small GTPases.Formula:C18H14N2O4Purezza:95.85% - 99.22%Colore e forma:SolidPeso molecolare:322.31Ref: TM-T1848
5mg49,00€10mg79,00€25mg140,00€50mg259,00€100mg374,00€200mg560,00€500mg883,00€1mL*10mM (DMSO)87,00€NH125
CAS:NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.Formula:C27H45IN2Purezza:98.60%Colore e forma:SolidPeso molecolare:524.56Ref: TM-T6605
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg264,00€50mg454,00€100mg655,00€1mL*10mM (DMSO)87,00€CX546
CAS:CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.Formula:C14H17NO3Purezza:99.75%Colore e forma:SolidPeso molecolare:247.295-Aminolevulinic acid hydrochloride
CAS:5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.Formula:C5H10ClNO3Purezza:98% - 99.97%Colore e forma:White To Pale Yellow Crystals OrPeso molecolare:167.59Ulipristal acetate
CAS:Ulipristal acetate (CDB-2914) is an oral selective progesterone modulator used for emergency contraception and suppressing uterine growths.Formula:C30H37NO4Purezza:98.83% - 99.94%Colore e forma:SolidPeso molecolare:475.62Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Formula:C40H57N5O7Purezza:99.6% - 99.84%Colore e forma:SolidPeso molecolare:719.91Nidufexor
CAS:Nidufexor is an agonist for the farnesoid X receptor (FXR).Formula:C27H22ClN3O4Purezza:98.67%Colore e forma:SolidPeso molecolare:487.93Ref: TM-T4S0797
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mg93,00€100mg125,00€500mg266,00€1mL*10mM (DMSO)55,00€Ginkgetin
CAS:Ginkgetin: antiviral, antifungal, anti-inflammatory; COX-2 reducer; STAT3 inhibitor; pro-apoptotic in cancer; neuroprotective in Parkinson's.Formula:C32H22O10Purezza:98.63% - 99.94%Colore e forma:SolidPeso molecolare:566.51Ref: TM-T4S2126
1mg46,00€5mg92,00€10mg146,00€25mg250,00€50mg369,00€100mg545,00€200mg777,00€1mL*10mM (DMSO)114,00€Rilmenidine Phosphate
CAS:Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.Formula:C10H19N2O5PPurezza:99.99% - ≥95%Colore e forma:SolidPeso molecolare:278.24Ref: TM-T6641
1mg35,00€5mg71,00€10mg87,00€25mg160,00€50mg244,00€100mg383,00€200mg557,00€1mL*10mM (DMSO)71,00€Metformin
CAS:<p>Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.</p>Formula:C4H11N5Purezza:99.77% - >99.99%Colore e forma:SolidPeso molecolare:129.16Indomethacin farnesil
CAS:Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.Formula:C34H40ClNO4Purezza:97.29%Colore e forma:SolidPeso molecolare:562.14SB 202190
CAS:SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.Formula:C20H14FN3OPurezza:98% - 99.84%Colore e forma:Pale YellowPeso molecolare:331.34CaMKII-IN-1
CAS:CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).Formula:C29H30ClN5O2SPurezza:99.69%Colore e forma:SolidPeso molecolare:548.1Ref: TM-T14860
1mg50,00€2mg71,00€5mg113,00€10mg166,00€25mg334,00€50mg520,00€100mg750,00€1mL*10mM (DMSO)137,00€Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Formula:C15H12O8Purezza:96.68% - 98.229%Colore e forma:SolidPeso molecolare:320.25MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Formula:C17H21N7O4Purezza:97.74% - >99.99%Colore e forma:SolidPeso molecolare:387.39(-)-Epicatechin gallate
CAS:(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.Formula:C22H18O10Purezza:99.16% - 99.93%Colore e forma:SolidPeso molecolare:442.371-Monomyristin
CAS:1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterialFormula:C17H34O4Purezza:99.58%Colore e forma:SolidPeso molecolare:302.45Icariin
CAS:Icariin (Ieariline) is a flavonol glycoside that inhibits PDE5 and PDE4 activity and is a PPARα activator. Cost-effective and quality-assured.Formula:C33H40O15Purezza:97.82% - 98.3%Colore e forma:SolidPeso molecolare:676.66CFTR(inh)-172
CAS:CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Formula:C18H10F3NO3S2Purezza:98% - 99.72%Colore e forma:SolidPeso molecolare:409.4Ref: TM-T2355
1mg35,00€2mg46,00€5mg66,00€10mg97,00€25mg188,00€50mg359,00€100mg530,00€1mL*10mM (DMSO)69,00€Syringin
CAS:Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.Formula:C17H24O9Purezza:98.89% - 99.96%Colore e forma:SolidPeso molecolare:372.37VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Formula:C25H23Cl2N7O4Purezza:97.03% - 99.55%Colore e forma:SolidPeso molecolare:556.4Pitavastatin calcium
CAS:Pitavastatin calcium (NK-104), a inhibitor of HMG-CoA reductase, lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans.Formula:C50H46CaF2N2O8Purezza:98.89% - >99.99%Colore e forma:White To Off-White PowderPeso molecolare:880.98Ref: TM-T2534
5mg39,00€10mg52,00€25mg70,00€50mg92,00€100mg127,00€200mg227,00€500mgPrezzo su richiesta1mL*10mM (DMSO)59,00€Tarenflurbil
CAS:Tarenflurbil, the R-enantiomer of flurbiprofen, lacks COX inhibition and was tested for Alzheimer's treatment.Formula:C15H13FO2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:244.26Efavirenz
CAS:Efavirenz (DMP 266) is an HIV-1 inhibitor, affecting reverse transcriptase and various cytochrome P450 enzymes.Formula:C14H9ClF3NO2Purezza:99.2% - 99.84%Colore e forma:White To Slightly Pink Crystalline PowderPeso molecolare:315.67Ref: TM-T2393
1g404,00€5mg42,00€10mg52,00€25mg71,00€50mg89,00€100mg116,00€500mg273,00€1mL*10mM (DMSO)49,00€D4476
CAS:D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).Formula:C23H18N4O3Purezza:99.7% - 99.96%Colore e forma:SolidPeso molecolare:398.41Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurezza:97.64% - 99.85%Colore e forma:SolidPeso molecolare:469.54Skatole
CAS:Skatole (3-Methyl-1H-indole), produced by bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.Formula:C9H9NPurezza:99.74%Colore e forma:Leaves From Petroleum Ether; White-Brown Scales SolidPeso molecolare:131.17MW-150
CAS:MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.Formula:C24H23N5Purezza:97.35% - 99.27%Colore e forma:SolidPeso molecolare:381.47Ref: TM-T5494
1mg39,00€5mg96,00€10mg153,00€25mg305,00€50mg454,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)114,00€Lumefantrine
CAS:Lumefantrine, an antimalarial, treats malaria with artemether, effective against Plasmodium spp. including in chloroquine-resistant areas.Formula:C30H32Cl3NOPurezza:98.36%Colore e forma:Yellow SolidPeso molecolare:528.94Shogaol
CAS:6-Shogaol: anti-inflammatory, analgesic, antipyretic, protects cartilage, arrests cancer cell growth, inhibits metastasis.Formula:C17H24O3Purezza:98.26% - 99.93%Colore e forma:SolidPeso molecolare:276.37Ref: TM-T6S1699
2mg40,00€5mg58,00€10mg96,00€25mg170,00€50mg268,00€100mg409,00€500mg888,00€1mL*10mM (DMSO)64,00€Deoxypodophyllotoxin
CAS:Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.Formula:C22H22O7Purezza:99.65% - 99.84%Colore e forma:SolidPeso molecolare:398.41Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formula:C33H38N4O6Purezza:98% - 99.92%Colore e forma:SolidPeso molecolare:586.68LY2109761
CAS:LY2109761: a TGF-β dual inhibitor, Ki=38 nM (TβRI) & 300 nM (TβRII), hinders Smad2 phosphorylation.Formula:C26H27N5O2Purezza:97% - 99.83%Colore e forma:SolidPeso molecolare:441.52Ref: TM-T2123
2mg47,00€5mg70,00€10mg111,00€25mg188,00€50mg335,00€100mg507,00€200mg730,00€1mL*10mM (DMSO)77,00€
