Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1495 prodotti di "Autofagia"
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OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formula:C30H30F3N5OPurezza:98.69%Colore e forma:SolidPeso molecolare:533.59Ref: TM-T5485
1mg88,00€5mg187,00€10mg298,00€25mg533,00€50mg755,00€100mg1.008,00€200mg1.359,00€1mL*10mM (DMSO)220,00€Ixazomib
CAS:Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.Formula:C14H19BCl2N2O4Purezza:98% - 99.77%Colore e forma:SolidPeso molecolare:361.03SBE13 Hydrochloride
CAS:SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.Formula:C24H28Cl2N2O4Purezza:99.00% - ≥95%Colore e forma:SolidPeso molecolare:479.4Oxyphenisatin acetate
CAS:Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.Formula:C24H19NO5Purezza:98% - 99.35%Colore e forma:SolidPeso molecolare:401.41Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurezza:99.36%Colore e forma:SolidPeso molecolare:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Formula:C25H21N7O3Purezza:93.28% - 98.3%Colore e forma:SolidPeso molecolare:467.48Ref: TM-T6110
1mg46,00€2mg60,00€5mg90,00€10mg170,00€25mg340,00€50mg532,00€100mg760,00€500mg1.558,00€1mL*10mM (DMSO)92,00€Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purezza:97.14% - 98.80%Colore e forma:SolidPeso molecolare:527.66Ref: TM-T6277
1g532,00€5mg34,00€10mg52,00€25mg74,00€50mg96,00€100mg120,00€200mg213,00€500mg359,00€1mL*10mM (DMSO)42,00€Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurezza:98% - 99.81%Colore e forma:SolidPeso molecolare:317.21Ambroxol hydrochloride
CAS:Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract.Formula:C13H18Br2N2O·HClPurezza:99.70%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:414.56CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purezza:99.66%Colore e forma:SolidPeso molecolare:486.49Ref: TM-T5312
2mg39,00€5mg58,00€10mg85,00€25mg156,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)63,00€ZLN005
CAS:ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.Formula:C17H18N2Purezza:98.59% - >99.99%Colore e forma:SolidPeso molecolare:250.34TWS119
CAS:TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiationFormula:C18H14N4O2Purezza:98.14% - 99.63%Colore e forma:SolidPeso molecolare:318.33Rutin hydrate
CAS:Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.Formula:C27H32O17Purezza:97.23%Colore e forma:SolidPeso molecolare:628.53Liensinine diperchlorate
CAS:Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus.Formula:C37H44Cl2N2O14Purezza:99.8% - ≥95%Colore e forma:SolidPeso molecolare:811.67Bafilomycin A1
CAS:Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible.Formula:C35H58O9Purezza:95.87% - 99.36%Colore e forma:SolidPeso molecolare:622.83Belinostat
CAS:Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.Formula:C15H14N2O4SPurezza:99.75% - >99.99%Colore e forma:SolidPeso molecolare:318.35Ref: TM-T8517
5mg46,00€10mg65,00€25mg92,00€50mg137,00€100mg195,00€200mg290,00€500mg492,00€1mL*10mM (DMSO)59,00€Quisinostat
CAS:Quisinostat (JNJ-26481585), a second-gen HDAC inhibitor, is most potent for HDAC1 (IC50 0.11 nM) and selectively affects HDACs 2, 4, 10, and 11.Formula:C21H26N6O2Purezza:96.01% - ≥98%Colore e forma:SolidPeso molecolare:394.47Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Formula:C19H20O6Purezza:99.88%Colore e forma:SolidPeso molecolare:344.36Veliparib
CAS:Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.Formula:C13H16N4OPurezza:98.66% - 99%Colore e forma:SolidPeso molecolare:244.29Ref: TM-T2591
5mg57,00€10mg81,00€25mg127,00€50mg207,00€100mg331,00€200mg540,00€500mg852,00€1mL*10mM (DMSO)64,00€Genistein
CAS:Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.Formula:C15H10O5Purezza:98.22% - 99.64%Colore e forma:Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidPeso molecolare:270.24(1E,6E)-Bis(demethoxy)curcumin
CAS:(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.Formula:C19H16O4Purezza:97.45%Colore e forma:SolidPeso molecolare:308.33Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.
Formula:C27H45NO2Purezza:99.94% - 99.98%Colore e forma:SolidPeso molecolare:415.65GNE-7915
CAS:GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.Formula:C19H21F4N5O3Purezza:98% - ≥95%Colore e forma:SolidPeso molecolare:443.4Ref: TM-T1945
5mg44,00€10mg58,00€25mg108,00€50mg177,00€100mg299,00€200mg389,00€500mg645,00€1mL*10mM (DMSO)48,00€Dehydropachymic acid
CAS:Dehydropachymic acid shows antiinflammatory activity.Formula:C33H50O5Purezza:99.61% - 99.78%Colore e forma:SolidPeso molecolare:526.75Notoginsenoside Fc
CAS:1. Notoginsenoside Fc has perfect anti-platelet aggregatory effect.
Formula:C58H98O26Purezza:99.22% - 99.94%Colore e forma:SolidPeso molecolare:1211.38Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Formula:C28H22Cl3N3O5Purezza:99.86% - ≥95%Colore e forma:SolidPeso molecolare:586.85Ref: TM-T7436
1mg50,00€2mg77,00€5mg124,00€10mg188,00€25mg376,00€50mg567,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)158,00€Rosuvastatin
CAS:Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.Formula:C22H28FN3O6SPurezza:95.24% - 99.95%Colore e forma:SolidPeso molecolare:481.54STF-31
CAS:STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.Formula:C23H25N3O3SPurezza:99.55% - >99.99%Colore e forma:SolidPeso molecolare:423.53Ref: TM-T5S2358
1mg52,00€2mg72,00€5mg111,00€10mg144,00€25mg207,00€50mg311,00€100mg472,00€1mL*10mM (DMSO)123,00€PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purezza:98.82%Colore e forma:SolidPeso molecolare:394.47Liensinine
CAS:1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.Formula:C37H42N2O6Purezza:98.92% - 99.93%Colore e forma:White-Like PowderPeso molecolare:610.74Atorvastatin hemicalcium salt
CAS:Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.Formula:C33H34FN2O5CaPurezza:99.27% - >99.99%Colore e forma:White Crystalline PowderPeso molecolare:577.67CZC-54252
CAS:CZC-54252 is a potent inhibitor of LRRK2.Formula:C22H25ClN6O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:504.99Nilotinib monohydrochloride monohydrate
CAS:Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosineFormula:C28H22F3N7O·HCl·H2OPurezza:99.93%Colore e forma:SolidPeso molecolare:583.99Autogramin-2
CAS:Autogramin-2 (tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) potently inhibits autophagy induced by eitherFormula:C21H27N3O4SPurezza:96.25%Colore e forma:SolidPeso molecolare:417.52Vismodegib
CAS:Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).Formula:C19H14Cl2N2O3SPurezza:98% - 99.82%Colore e forma:SolidPeso molecolare:421.3PFK-158
CAS:PFK-158 is an effective and specific inhibitor PFKFB3.Formula:C18H11F3N2OPurezza:95.49% - 99.16%Colore e forma:SolidPeso molecolare:328.29Ref: TM-T3105
1mg34,00€2mg46,00€5mg66,00€10mg90,00€25mg170,00€50mg259,00€100mg409,00€1mL*10mM (DMSO)73,00€Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purezza:98% - 99.96%Colore e forma:SolidPeso molecolare:615.39Levosimendan
CAS:Levosimendan (OR1259) is a calcium sensitizer for acute heart failure, enhancing cardiac contractility without raising calcium levels.
Formula:C14H12N6OPurezza:99.37% - 99.91%Colore e forma:Yellow Crystalline PowderPeso molecolare:280.28Wogonin
CAS:Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
Formula:C16H12O5Purezza:98% - 99.8%Colore e forma:Yellow CrystalPeso molecolare:284.26SU9516
CAS:SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.Formula:C13H11N3O2Purezza:99.34% - 99.96%Colore e forma:SolidPeso molecolare:241.25Ref: TM-T6167
1mg35,00€2mg50,00€5mg73,00€10mg103,00€25mg208,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)74,00€10058-F4
CAS:10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Formula:C12H11NOS2Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:249.35Soyasapogenol B
CAS:Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.Formula:C30H50O3Purezza:99.51% - 99.81%Colore e forma:SolidPeso molecolare:458.72CZC-25146
CAS:CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).Formula:C22H25FN6O4SPurezza:97.68%Colore e forma:SolidPeso molecolare:488.54N-Benzyllinolenamide
CAS:N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).Formula:C25H37NOPurezza:98.7% - 99.92%Colore e forma:SolidPeso molecolare:367.57Ref: TM-TN1965
1mg86,00€5mg180,00€10mg274,00€25mg465,00€50mg663,00€100mg919,00€200mg1.216,00€1mL*10mM (DMSO)187,00€Amsacrine hydrochloride
CAS:Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Formula:C21H20ClN3O3SPurezza:99.05% - 99.92%Colore e forma:SolidPeso molecolare:429.92Pantoprazole
CAS:Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal refluxFormula:C16H15F2N3O4SPurezza:97.16% - 99.63%Colore e forma:Almost White SolidPeso molecolare:383.37Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formula:C26H22N2O2Purezza:97.12% - 99.96%Colore e forma:SolidPeso molecolare:394.47Ref: TM-T6671
2mg43,00€5mg58,00€10mg93,00€25mg178,00€50mg343,00€100mg509,00€500mg1.121,00€1mL*10mM (DMSO)58,00€Embelin
CAS:Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).Formula:C17H26O4Purezza:97.07% - 99.88%Colore e forma:SolidPeso molecolare:294.39GNE-9605
CAS:GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).Formula:C17H20ClF4N7OPurezza:98.55% - 98.75%Colore e forma:SolidPeso molecolare:449.83
