Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1527 prodotti per "Autofagia".
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Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Colore e forma:Odour SolidDOTA-CXCR4-L
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancerFormula:C58H78N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1223.34Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formula:C43H52N6O19P3Colore e forma:SolidPeso molecolare:1049.82G-quadruplex DNA fluorescence probe 1
Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.Formula:C27H31IN2O3Colore e forma:SolidPeso molecolare:558.45ALA-A2 peptide
ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.Formula:C67H111N21O19SColore e forma:SolidPeso molecolare:1546.79SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormula:C356H578N106O93S4Purezza:98%Colore e forma:SolidPeso molecolare:7959.34Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formula:C23H26ClI2NO3Purezza:98%Colore e forma:SolidPeso molecolare:653.72RK-682 (calcium salt)
CAS:RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Formula:C42H74CaO10Colore e forma:SolidPeso molecolare:779.122MW-150 hydrochloride
CAS:MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.Formula:C24H24ClN5Colore e forma:SolidPeso molecolare:417.93Acetazolamide
CAS:Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.Formula:C4H6N4O3S2Purezza:99.61% - 99.94%Colore e forma:White SolidPeso molecolare:222.25Cyanine 5 Tyramide methyl indole
Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.Formula:C40H47N3O8S2Colore e forma:SolidPeso molecolare:761.95Calmodulin-Dependent Protein Kinase II (290-309)
CAS:Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase IIFormula:C103H185N31O24SPurezza:98%Colore e forma:SolidPeso molecolare:2273.83TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formula:C32H55N3O10SColore e forma:SolidPeso molecolare:673.86Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFormula:C16H14F2N3NaO4SH2OPurezza:98.32%Colore e forma:SolidPeso molecolare:432.37Gefitinib-D3
CAS:Gefitinib-D3 is the deuterated form of Gefitinib. Gefitinib (T1181) (ZD1839) is a potent, selective, and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. It selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Additionally, Gefitinib (T1181) can induce autophagy (autophagy) and exhibits antitumor activity.Formula:C22H24ClFN4O3Colore e forma:SolidPeso molecolare:449.92Obeticholic acid-D5
CAS:Obeticholic acid-D5 is the deuterated form of Obeticholic acid. Obeticholic acid (T1789) (INT-747) acts as a potent, selective, and orally active FXR agonist with an EC50 of 99 nM, exhibiting both anticholeretic and anti-inflammatory properties. Additionally, Obeticholic acid (T1789) can induce autophagy (autophagy).Formula:C26H44O4Colore e forma:SolidPeso molecolare:425.66(R)-Hydroxychloroquine phosphate
CAS:(R)-Hydroxychloroquine ((R)-HCQ) phosphate is an isomer of Hydroxychloroquine. It inhibits insulin-metabolizing enzymes in the cytosolic fraction of liver homogenates in both healthy and diabetic rats.Formula:C18H28ClN3O5SColore e forma:SolidPeso molecolare:433.95Ambroxol-D5 hydrochloride
CAS:Ambroxol-D5 hydrochloride is the deuterated variant of Ambroxol hydrochloride. Ambroxol hydrochloride (T6234) (NA-872 hydrochloride) is the active metabolite of the precursor bromhexine and exhibits potent expectorant properties. It acts as a glucocerebrosidase (GCase) chaperone, enhancing the enzyme's activity. Additionally, Ambroxol hydrochloride (T6234) can induce autophagy in the lungs and holds potential for research in Parkinson's disease and neuronopathic Gaucher's disease.Formula:C13H19Br2ClN2OColore e forma:SolidPeso molecolare:419.60Cisatracurium besylate
CAS:Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.Formula:C53H72N2O12·2C6H5O3SPurezza:97.89% - 99.85%Colore e forma:SolidPeso molecolare:1243.48Ref: TM-T1459
10mg44,00€1mL*10mM (DMSO)57,00€25mg66,00€50mg105,00€100mg170,00€200mg250,00€500mg427,00€Thalidomide-PIP-(R)C-pyrrolidine-boc
CAS:Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate comprising an E3 ligase ligand and a linker, specifically containing Thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of the CRBN protein, and is a crucial intermediate in synthesizing complete PROTAC molecules.Formula:C27H35N5O6Peso molecolare:525.6
