Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1494 prodotti di "Autofagia"
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Pinosylvin
CAS:Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.Formula:C14H12O2Purezza:99.89% - 99.91%Colore e forma:SolidPeso molecolare:212.24Entinostat
CAS:Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.Formula:C21H20N4O3Purezza:98% - 99.74%Colore e forma:SolidPeso molecolare:376.41CCT128930 hydrochloride
CAS:CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.Formula:C18H21Cl2N5Purezza:98.55%Colore e forma:SolidPeso molecolare:378.3Ref: TM-T6303L
1mg52,00€5mg97,00€10mg157,00€25mg254,00€50mg379,00€100mg552,00€200mg815,00€1mL*10mM (DMSO)110,00€Gartanin
CAS:Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.Formula:C23H24O6Purezza:99.64% - 99.85%Colore e forma:SolidPeso molecolare:396.43Ref: TM-TN1677
1mg92,00€5mg283,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)298,00€(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurezza:97.57% - 99.97%Colore e forma:SolidPeso molecolare:456.99Ref: TM-T2110
1mg35,00€2mg44,00€5mg60,00€10mg79,00€25mg96,00€50mg144,00€100mg188,00€200mg283,00€500mg512,00€1mL*10mM (DMSO)66,00€Autogramin-1
CAS:Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.Formula:C23H27N5O5SPurezza:97.69% - 99.25%Colore e forma:SolidPeso molecolare:485.56PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in
Formula:C17H13Br2N5OS·HBrPurezza:99.91%Colore e forma:SolidPeso molecolare:576.1Ref: TM-T6178
1mg37,00€5mg78,00€10mg124,00€25mg265,00€50mg465,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)89,00€NSC 185058
CAS:NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.Formula:C11H9N3SPurezza:99.27%Colore e forma:SolidPeso molecolare:215.27PF-543 hydrochloride
CAS:PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2Formula:C27H32ClNO4SPurezza:98.9% - 99.93%Colore e forma:SolidPeso molecolare:502.1XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Formula:C23H22FN3O4SPurezza:99.39% - 99.53%Colore e forma:SolidPeso molecolare:455.5Autocamtide-2-related inhibitory peptide
CAS:Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Formula:C64H116N22O19Purezza:>99.99%Colore e forma:SolidPeso molecolare:1497.74PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Formula:C17H15N5OPurezza:98.61% - 99.62%Colore e forma:SolidPeso molecolare:305.33Onjisaponin B
CAS:Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-Formula:C75H112O35Purezza:99.20% - 99.972%Colore e forma:SolidPeso molecolare:1573.67Ref: TM-TN1140
5mg92,00€10mg163,00€25mg266,00€50mg393,00€100mgPrezzo su richiesta1mL*10mM (DMSO)238,00€URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purezza:99.32% - 99.98%Colore e forma:SolidPeso molecolare:421.54A-867744
CAS:A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).Formula:C20H19ClN2O3SPurezza:95.66%Colore e forma:SolidPeso molecolare:402.89Juglanin
CAS:Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Formula:C20H18O10Purezza:98.8% - 99.33%Colore e forma:SolidPeso molecolare:418.35Spautin-1
CAS:Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.Formula:C15H11F2N3Purezza:97.69% - 98.99%Colore e forma:SolidPeso molecolare:271.26Ref: TM-T1937
2mg37,00€5mg52,00€10mg66,00€25mg111,00€50mg197,00€100mg298,00€200mg444,00€1mL*10mM (DMSO)58,00€TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purezza:99.55% - 99.94%Colore e forma:SolidPeso molecolare:351.32Ref: TM-T4645
2mg34,00€5mg50,00€10mg80,00€25mg147,00€50mg224,00€100mg313,00€200mg439,00€1mL*10mM (DMSO)67,00€PI3Kδ-IN-15
CAS:CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.Formula:C21H16FN7OPurezza:99.61%Colore e forma:SolidPeso molecolare:401.4Lanatoside C
CAS:Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.Formula:C49H76O20Purezza:98.3% - >99.99%Colore e forma:SolidPeso molecolare:985.12
