Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1494 prodotti di "Autofagia"
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Hoechst 33342
CAS:Hoechst 33342 (bisBenzimide H 33342) is a benzimidazole fluorescent dye and a cell-permeable fluorescent DNA dye. High-Quality, Low-Cost!Formula:C27H28N6OPurezza:98.12% - 99.75%Colore e forma:Yellow-Green PowderPeso molecolare:452.55Sofalcone
CAS:Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.Formula:C27H30O6Purezza:97.55%Colore e forma:SolidPeso molecolare:450.52Hesperadin
CAS:Hesperadin(IC50=250 nM) effectively inhibits Aurora B.Formula:C29H32N4O3SPurezza:98.04% - 99.44%Colore e forma:SolidPeso molecolare:516.65Nitroprusside disodium dihydrate
CAS:Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.Formula:C5H4FeN6Na2O3Purezza:98%Colore e forma:Bright RedPeso molecolare:297.95UNC1999
CAS:UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).Formula:C33H43N7O2Purezza:99.19% - >99.99%Colore e forma:SolidPeso molecolare:569.74Ref: TM-T3057
1mg34,00€2mg46,00€5mg66,00€10mg92,00€25mg167,00€50mg259,00€100mg401,00€200mg580,00€1mL*10mM (DMSO)94,00€Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purezza:99.97% - >99.99%Colore e forma:SolidPeso molecolare:346.42Ref: TM-T4672
1mg90,00€5mg203,00€10mg350,00€25mg578,00€50mg797,00€100mg1.071,00€500mg2.187,00€1mL*10mM (DMSO)224,00€α-Thujone
CAS:α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.Formula:C10H16OPurezza:97.02% - 98.41%Colore e forma:Less Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996) Colorless Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996)Peso molecolare:152.23Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purezza:99% - 99.98%Colore e forma:SolidPeso molecolare:392.49Ref: TM-T2588
1mg38,00€2mgPrezzo su richiesta5mg81,00€10mg127,00€25mg205,00€50mg304,00€100mg439,00€200mgPrezzo su richiesta1mL*10mM (DMSO)88,00€Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formula:C25H17F2N5O3SPurezza:98% - 99.8%Colore e forma:SolidPeso molecolare:505.5Urolithin A
CAS:Urolithin A is a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Cost-effective and quality-assured.Formula:C13H8O4Purezza:99.14% - 99.67%Colore e forma:SolidPeso molecolare:228.2Ref: TM-T7174
5mg49,00€10mg72,00€25mg130,00€50mg187,00€100mg320,00€200mg472,00€500mg753,00€1mL*10mM (DMSO)50,00€OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formula:C21H22N6O3Purezza:97.42%Colore e forma:SolidPeso molecolare:406.44Ref: TM-T6319
1mg42,00€2mg52,00€5mg86,00€10mg138,00€25mg248,00€50mg389,00€100mg567,00€1mL*10mM (DMSO)88,00€Nocodazole
CAS:Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.Formula:C14H11N3O3SPurezza:98% - 99.91%Colore e forma:Physical Description White Powder (Ntp 1992)Peso molecolare:301.32Ref: TM-T2802
5mg34,00€10mg52,00€25mg94,00€50mg165,00€100mg268,00€200mg399,00€500mg647,00€1mL*10mM (DMSO)38,00€Atorvastatin hemicalcium trihydrate
CAS:Atorvastatin hemicalcium trihydrate, an oral HMG-CoA reductase inhibitor, lowers blood lipids and inhibits SV-SMC with IC50s: 0.39/2.39 μM.Formula:C33H35FN2O5Ca·3H2OColore e forma:SolidPeso molecolare:632.73Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formula:C18H18N4O4Purezza:99.79%Colore e forma:SolidPeso molecolare:354.36Ref: TM-T16681
1mg90,00€5mg203,00€10mg358,00€25mg617,00€50mg878,00€100mg1.189,00€1mL*10mM (DMSO)225,00€Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formula:C35H28F3N5O2Purezza:98.3% - 99.33%Colore e forma:SolidPeso molecolare:607.62Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
Formula:C29H25F4N3O5SPurezza:99.3% - 99.85%Colore e forma:SolidPeso molecolare:603.58Ref: TM-T4379
1mg87,00€5mg166,00€10mg248,00€25mg437,00€50mg665,00€100mg1.008,00€200mg1.520,00€500mg2.252,00€Aliskiren hydrochloride
CAS:Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is a selective, orally active, renin inhibitor (IC50: 1.5 nM). Cachexia.Formula:C30H54ClN3O6Colore e forma:SolidPeso molecolare:588.23Crenolanib
CAS:Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).Formula:C26H29N5O2Purezza:98.40% - 99.73%Colore e forma:SolidPeso molecolare:443.54SBI-0206965
CAS:SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
Formula:C21H21BrN4O5Purezza:99.13%Colore e forma:SolidPeso molecolare:489.32
