Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1491 prodotti di "Autofagia"
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LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purezza:98% - 99.96%Colore e forma:Pale Yellow SolidPeso molecolare:307.34NS1643
CAS:NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.Formula:C15H10F6N2O3Purezza:98.37% - 99.31%Colore e forma:SolidPeso molecolare:380.24Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formula:C9H12N2O5Purezza:99.04% - >99.99%Colore e forma:SolidPeso molecolare:228.2STF-62247
CAS:STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.
Formula:C15H13N3SPurezza:99.6% - 99.67%Colore e forma:SolidPeso molecolare:267.35Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurezza:98% - 99.06%Colore e forma:SolidPeso molecolare:399.49Polydatin
CAS:Polydatin, a resveratrol glycoside from Polygonum cuspidatum, inhibits platelet aggregation, alters lipid ratios, and modulates cell functions.Formula:C20H22O8Purezza:97.2% - 98.94%Colore e forma:White Fine PowderPeso molecolare:390.38Tacrolimus monohydrate
CAS:Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.Formula:C44H71NO13Purezza:97.07% - 98.05%Colore e forma:SolidPeso molecolare:822.05Tubastatin A
CAS:Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.Formula:C20H21N3O2Purezza:97.22% - 99.51%Colore e forma:SolidPeso molecolare:335.4Ref: TM-T1966
10mg46,00€25mg60,00€50mg74,00€100mg105,00€200mg160,00€500mg259,00€1mL*10mM (DMSO)44,00€NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormula:C27H29N5OPurezza:98.7% - 99.86%Colore e forma:SolidPeso molecolare:439.55CD437
CAS:CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.Formula:C27H26O3Purezza:98.92% - 99.63%Colore e forma:SolidPeso molecolare:398.49PHA-665752
CAS:PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.Formula:C32H34Cl2N4O4SPurezza:97.05% - 98.82%Colore e forma:SolidPeso molecolare:641.61Lys05
CAS:Lys05, a potent autophagy inhibitor, outperforms HCQ in cancer treatment, showing promise for drug development.Formula:C23H26Cl5N5Purezza:99.13% - 99.55%Colore e forma:SolidPeso molecolare:549.75MK-2206 dihydrochloride
CAS:MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent andFormula:C25H23Cl2N5OPurezza:99.228% - 99.94%Colore e forma:SolidPeso molecolare:480.39Ref: TM-T1952
2mg34,00€5mg49,00€10mg66,00€25mg90,00€50mg137,00€100mg205,00€200mg334,00€500mg552,00€1mL*10mM (DMSO)52,00€SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurezza:99.3% - >99.99%Colore e forma:SolidPeso molecolare:405.42PD146176
CAS:PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.
Formula:C15H11NSPurezza:98.00%Colore e forma:SolidPeso molecolare:237.32DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Formula:C22H20N4Purezza:98.93% - ≥95%Colore e forma:SolidPeso molecolare:340.42Ref: TM-T1969
2mg34,00€5mg52,00€10mg85,00€25mg152,00€50mg264,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)52,00€Diosgenin glucoside
CAS:Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis
Formula:C33H52O8Purezza:97.17% - 99.44%Colore e forma:SolidPeso molecolare:576.76Retro-2
CAS:Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, it protects HeLa cells against Ricin, Stx1 and Stx2.
Formula:C19H16N2OSPurezza:98.15%Colore e forma:SolidPeso molecolare:320.41Schisandrol B
CAS:Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.Formula:C23H28O7Purezza:99.14% - 99.95%Colore e forma:SolidPeso molecolare:416.46Ref: TM-T6S1917
5mg67,00€10mg90,00€25mg190,00€50mg286,00€100mg429,00€500mg982,00€1mL*10mM (DMSO)74,00€
