Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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VUF11211
CAS:VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Formula:C26H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:504.498-Nitro-cGMP
CAS:8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation.Formula:C10H11N6O9PColore e forma:SolidPeso molecolare:390.20CXCR4 antagonist 9
CAS:CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.Formula:C21H27FN6Colore e forma:SolidPeso molecolare:382.48Autophagy-IN-C1
CAS:Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.Formula:C29H28F6N4O2Colore e forma:SolidPeso molecolare:578.55SB-332235
CAS:SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.Formula:C13H10Cl3N3O4SColore e forma:SolidPeso molecolare:410.66Omeprazole Sodium
CAS:Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.Formula:C17H18N3NaO3SPurezza:99.84%Colore e forma:Clear In WaterPeso molecolare:367.4ICT5040
CAS:ICT5040 is a CXCR4 antagonist.Formula:C10H8F3N3OSColore e forma:SolidPeso molecolare:275.25Norswertianin
CAS:Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.Formula:C13H8O6Colore e forma:SolidPeso molecolare:260.2PF 750
CAS:PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.Formula:C22H23N3OPurezza:99.87%Colore e forma:SolidPeso molecolare:345.44Ref: TM-T16515
2mg39,00€5mg62,00€10mg87,00€25mg187,00€50mg298,00€100mg444,00€200mg635,00€500mg938,00€1mL*10mM (DMSO)67,00€Dilmapimod tosylate
CAS:Dilmapimod tosylate, a p38 MAPK inhibitor, targets IL-1β, was in phase III trials by GlaxoSmithKline for rheumatoid arthritis and more.Formula:C30H27F3N4O6SColore e forma:SolidPeso molecolare:628.62Quinacrine analog 34
CAS:Quinacrine: anti-protozoal, autophagy inhibitor (toxic at 2.5 μM). Analog 34 less toxic (LD50 = 27 μM), raises LC3-II protein, deacidifies lysosomes.Formula:C20H27ClN4Colore e forma:SolidPeso molecolare:358.91SMYD3-IN-2
SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.Formula:C26H21BrN2O4Colore e forma:SolidPeso molecolare:505.36CXCR4 modulator-2
CAS:CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.Formula:C21H32N8O2Colore e forma:SolidPeso molecolare:428.53NSC 33994
CAS:NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Formula:C28H42N2O2Purezza:98%Colore e forma:SolidPeso molecolare:438.65SR 3677 dihydrochloride
CAS:Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).Formula:C22H26Cl2N4O4Colore e forma:SolidPeso molecolare:481.37Glaucocalyxin B
CAS:Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).Formula:C22H30O5Purezza:99.13% - 99.35%Colore e forma:SolidPeso molecolare:374.47Ref: TM-TQ0309
1mg97,00€5mg235,00€10mg354,00€25mg582,00€50mgPrezzo su richiesta1mL*10mM (DMSO)243,00€Lamotrigine isethionate
CAS:Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.Formula:C11H13Cl2N5O4SColore e forma:SolidPeso molecolare:382.22PF-06371900
CAS:PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).Formula:C17H16N6O2SColore e forma:SolidPeso molecolare:368.41Ralimetinib
CAS:Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).Formula:C24H29FN6Purezza:99.16% - 99.21%Colore e forma:SolidPeso molecolare:420.53Ivacaftor benzenesulfonate
CAS:Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.Formula:C30H34N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.67
