Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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Momelotinib Mesylate
CAS:Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formula:C24H26N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:510.57Metofenazate
CAS:Metofenazate is an selective inhibitor of calmodulin .Formula:C31H36ClN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:598.15Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurezza:99.2% - 99.34%Colore e forma:Yellow Crystalline Powder SolidPeso molecolare:393.46DK-1-49
CAS:DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.Formula:C28H31N5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:549.71ACT-660602
CAS:ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Formula:C20H20F6N8OSColore e forma:SolidPeso molecolare:534.483HOI-BA-01
CAS:3HOI-BA-01 is a mammalian targeting effective rapamycin activation inhibitor.Formula:C19H15NO5Purezza:98%Colore e forma:SolidPeso molecolare:337.33FAAH-IN-1
CAS:FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.Formula:C20H19ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:398.91FKBP51F67V-selective antagonist Ligand2
CAS:FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 orFormula:C43H56N2O10Purezza:98%Colore e forma:SolidPeso molecolare:760.91LV-320
CAS:LV-320, potent ATG4B inhibitor; IC50: 24.5 μM, Kd: 16 μM. Blocks autophagy, stable, non-toxic, active in vivo. Useful for ATG4B research in cancer.Formula:C29H26ClNO2S2Purezza:98%Colore e forma:SolidPeso molecolare:520.11SA 47
CAS:SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.Formula:C17H26N4O3Purezza:98%Colore e forma:SolidPeso molecolare:334.41LRRK2-IN-10
CAS:LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2Formula:C20H15N5OPurezza:98%Colore e forma:SolidPeso molecolare:341.37BC-1485
CAS:BC-1485 is a small molecule inhibitor of FIEL1 that inhibits the degradation of PIAS4 and ameliorates fibrosis in a mouse model.Formula:C19H21N5O5SPurezza:97.03% - 97.15%Colore e forma:SolidPeso molecolare:431.47SB02024
CAS:SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Formula:C16H22F3N3O2Colore e forma:SolidPeso molecolare:345.36Rimacalib
CAS:Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).Formula:C22H23FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:394.44HF50731
CAS:HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Formula:C26H46N4Colore e forma:SolidPeso molecolare:414.67FR 167653 free base
CAS:FR 167653 is an oral p38 MAPK inhibitor for inflammation, trauma, ischemia relief; it suppresses TNF-α, IL-1β.Formula:C24H18FN5O2Purezza:98%Colore e forma:SolidPeso molecolare:427.43ROC-325
CAS:ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.Formula:C28H27ClN4OSPurezza:99.26%Colore e forma:SolidPeso molecolare:503.06Autophagy inducer 3
CAS:<p>Autophagy Inducer 3 triggers selective cancer cell death via autophagy, sparing healthy cells.</p>Formula:C24H43NO2Colore e forma:SolidPeso molecolare:377.6RNF5 inhibitor inh-02
CAS:RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR cystic fibrosis (CF).Formula:C23H20N4SPurezza:99.23%Colore e forma:SolidPeso molecolare:384.5Ref: TM-T35883
1mg86,00€5mg180,00€10mg311,00€25mg655,00€50mg1.121,00€100mg1.882,00€200mg2.547,00€1mL*10mM (DMSO)188,00€SR-17398
CAS:SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM).Formula:C14H18N4OPurezza:98%Colore e forma:SolidPeso molecolare:258.32
