DUB
Gli inibitori delle deubiquitinasi (DUB) mirano alle enzimi che rimuovono le molecole di ubiquitina dalle proteine, regolando così la stabilità, la localizzazione e l'attività delle proteine all'interno della cellula. Le deubiquitinasi svolgono ruoli essenziali in vari processi cellulari, tra cui la regolazione del ciclo cellulare, la riparazione del DNA e le risposte immunitarie. La disfunzione dell'attività delle DUB è legata al cancro, ai disturbi neurodegenerativi e alle infezioni virali. Gli inibitori delle DUB possono modulare questi processi, offrendo potenziali approcci terapeutici per queste condizioni. Presso CymitQuimica, forniamo inibitori delle DUB per supportare la tua ricerca in omeostasi proteica, oncologia e neurobiologia.
Trovati 110 prodotti per "DUB".
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IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Formula:C19H23ClN2OPurezza:98.94%Colore e forma:White SolidPeso molecolare:330.852GRL0617
CAS:GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).Formula:C20H20N2OPurezza:99.31%Colore e forma:SolidPeso molecolare:304.39C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formula:C17H8FNO3Purezza:97.22%Colore e forma:SolidPeso molecolare:293.2487HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formula:C25H28ClN3OPurezza:97.71%Colore e forma:SolidPeso molecolare:421.962MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formula:C30H37N3O4SPurezza:99.93%Colore e forma:White SolidPeso molecolare:535.697USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Formula:C26H30Cl2N4O3SColore e forma:SolidPeso molecolare:549.51Ga-CY03
Ga-CY03 (compound) is a FAP-tracing molecule designed based on the FAP inhibitor QI-18 and labeled with [Ga].Formula:C53H63F2GaN13O15Colore e forma:SolidPeso molecolare:1229.87(R)-CMPD-39
(R)-CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 μM. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.USP30-IN-20
USP30-IN-20 is an orally active USP30 inhibitor with a Kd of 1.61 μM and an IC50 of 12.8 μM. It induces ferroptosis by promoting the ubiquitination-mediated degradation of GPX4. This compound inhibits the proliferation, migration, and invasion of prostate cancer cells and induces G0/G1 phase arrest while increasing ROS levels. In a mouse xenograft model with PC3 cells, USP30-IN-20 demonstrates significant antitumor activity. It is applicable for advanced prostate cancer research.UBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Colore e forma:Odour SolidSubquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Formula:C20H27N3O4SColore e forma:SolidPeso molecolare:405.17223FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColore e forma:SolidPeso molecolare:447.596Q14
Q14 is a polypeptide derived from the transmembrane (TM) domain of USP30 (ubiquitin specific peptidase30) and is capable of inhibiting the deubiquitination activity of USP30 (IC50=57.2 nM). By hindering the interaction between USP30’s transmembrane and catalytic domains, it lowers USP30 activity. The Q14 polypeptide contains an LC3 interaction region (LIR) motif, enabling it to bind with LC3, thereby accelerating autophagosome formation and promoting mitophagy. Q14 is applicable in the study of neurodegenerative diseases, mitochondrial quality control, and cellular metabolism.Formula:C101H168N32O23Colore e forma:SolidPeso molecolare:2197.29601MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Colore e forma:Odour SolidUbiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Colore e forma:Odour SolidJAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.4433PROTAC USP7 Degrader-1
PROTACUSP7 Degrader-1 (Compound 40) is a PROTAC degrader specifically targeting ubiquitin-specific protease 7 (USP7) with a DC50 of 25 nM. It is utilized in cancer research, including studies on acute myeloid leukemia.BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Formula:C24H28F3N5O2SColore e forma:SolidPeso molecolare:507.57PROTAC USP7 Degrader-2
CAS:PROTACUSP7 Degrader-2 (Compound D16) is a potent and selective USP7 PROTAC degrader with a DC50 of 1.91 μM (in TE-12 cells). It inhibits the migration of upper gastrointestinal (UGI) cancer cells while exhibiting weak antiproliferative activity. This compound is utilized for research on metastatic UGI cancer.Formula:C42H44Cl2N8O6SPeso molecolare:859.82GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formula:C21H22N6O2Colore e forma:SolidPeso molecolare:390.44
