DUB
Gli inibitori delle deubiquitinasi (DUB) mirano alle enzimi che rimuovono le molecole di ubiquitina dalle proteine, regolando così la stabilità, la localizzazione e l'attività delle proteine all'interno della cellula. Le deubiquitinasi svolgono ruoli essenziali in vari processi cellulari, tra cui la regolazione del ciclo cellulare, la riparazione del DNA e le risposte immunitarie. La disfunzione dell'attività delle DUB è legata al cancro, ai disturbi neurodegenerativi e alle infezioni virali. Gli inibitori delle DUB possono modulare questi processi, offrendo potenziali approcci terapeutici per queste condizioni. Presso CymitQuimica, forniamo inibitori delle DUB per supportare la tua ricerca in omeostasi proteica, oncologia e neurobiologia.
Trovati 100 prodotti per "DUB".
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P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purezza:97.9% - 99.64%Colore e forma:Yellow SolidPeso molecolare:315.32STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFormula:C27H28N4O4SPurezza:99.64%Colore e forma:SolidPeso molecolare:504.6Ref: TM-T8706
1mg67,00€5mg152,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg507,00€50mg730,00€100mg1.018,00€P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formula:C12H7Cl2NO3S2Purezza:99.53% - 99.87%Colore e forma:SolidPeso molecolare:348.22VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purezza:98.53% - 99.91%Colore e forma:SolidPeso molecolare:469.39Ref: TM-T4067
1mg90,00€2mg146,00€5mg245,00€1mL*10mM (DMSO)251,00€10mg385,00€25mg645,00€50mg888,00€100mg1.234,00€ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formula:C23H24N6Purezza:99.87% - 99.96%Colore e forma:SolidPeso molecolare:384.48GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Formula:C20H18N4OPurezza:98.64%Colore e forma:SolidPeso molecolare:330.38Ref: TM-T5461
1mg66,00€2mg96,00€5mg144,00€1mL*10mM (DMSO)158,00€10mg236,00€25mg507,00€50mg730,00€100mg1.018,00€DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formula:C16H9N5OPurezza:99.34%Colore e forma:SolidPeso molecolare:287.28Ref: TM-T11112
1mg130,00€2mg178,00€5mg309,00€1mL*10mM (DMSO)324,00€10mg442,00€25mg705,00€50mg982,00€100mg1.333,00€500mg2.655,00€ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Formula:C24H18F3N3O3S2Purezza:99.35% - >99.99%Colore e forma:SolidPeso molecolare:517.54IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formula:C20H23N3O2Purezza:99.3%Colore e forma:SolidPeso molecolare:337.42Ref: TM-T9375
1mg48,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg301,00€50mg424,00€100mg605,00€200mg845,00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Formula:C20H20N4O2Purezza:96.59% - 98.2%Colore e forma:SolidPeso molecolare:348.4TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purezza:98.87% - 99.34%Colore e forma:SolidPeso molecolare:283.92USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formula:C26H22F4N6OPurezza:99.88% - 99.99%Colore e forma:SolidPeso molecolare:510.486Ref: TM-T63518
1mg164,00€5mg389,00€1mL*10mM (DMSO)452,00€10mg515,00€25mg783,00€50mg1.054,00€100mg1.423,00€POSH-IN-1
CAS:POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide （e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.Formula:C14H8FNO3SPurezza:99.29%Colore e forma:SolidPeso molecolare:289.28VCPIP1-IN-2
CAS:VCPIP1-IN-1 (Compound 076) is an inhibitor of VCPIP1.Formula:C14H13ClFN3O2Colore e forma:SolidPeso molecolare:309.72MF-095
CAS:MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.Formula:C27H31N3O4SColore e forma:SolidPeso molecolare:493.62USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C22H18Cl2N2O3SPurezza:98.39%Colore e forma:Yellow SolidPeso molecolare:461.36XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formula:C32H42N6O4Colore e forma:SolidPeso molecolare:574.718RK64
CAS:8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .Formula:C14H16N8O2SColore e forma:SolidPeso molecolare:360.4Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Formula:C30H24N6O2S4Purezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:628.81USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C23H20Cl2N2O3SPurezza:99.92%Colore e forma:White SolidPeso molecolare:475.39
