Recettore dell'endotelina
I recettori dell'endotelina sono GPCR che mediano gli effetti delle endoteline, potenti peptidi vasocostrittori che giocano un ruolo significativo nella regolazione del tono vascolare, nel controllo della pressione sanguigna e nella proliferazione cellulare. Gli antagonisti dei recettori dell'endotelina sono utilizzati nel trattamento di condizioni come l'ipertensione arteriosa polmonare e l'insufficienza cardiaca. Questi recettori sono anche importanti bersagli nella ricerca sulle malattie cardiovascolari e sul cancro. Presso CymitQuimica, offriamo una selezione di modulatori dei recettori dell'endotelina di alta qualità per supportare la tua ricerca in biologia cardiovascolare, oncologia e fisiologia vascolare.
Trovati 83 prodotti di "Recettore dell'endotelina"
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Sulfisoxazole
CAS:<p>Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.</p>Formula:C11H13N3O3SPurezza:99.87% - 99.98%Colore e forma:White To Cream PowderPeso molecolare:267.30Enrasentan
CAS:Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure and protects myocardial function.Formula:C29H30O8Purezza:97.9% - 98.39%Colore e forma:SolidPeso molecolare:506.54Atrial Natriuretic Peptide (ANP) (1-28), rat
CAS:Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.Formula:C128H205N45O39S2Purezza:98%Colore e forma:SolidPeso molecolare:3062.41Atrial natriuretic factor (1-28) (rat) TFA
ANP (1-28), rat (TFA) inhibits Ang II-induced endothelin-1 secretion; main circulating ANP form in rats.Formula:C130H206N45F3O41S2Purezza:98%Colore e forma:SolidPeso molecolare:3176.43ACT-373898
CAS:<p>ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1</p>Formula:C15H17BrN4O5SColore e forma:SolidPeso molecolare:445.29IRL-1038
CAS:<p>ETB endothelin receptor antagonist</p>Formula:C68H92N14O15S2Purezza:98%Colore e forma:SolidPeso molecolare:1409.67[Ala1,3,11,15]-Endothelin
CAS:Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).Formula:C109H163N25O32SPurezza:98%Colore e forma:SolidPeso molecolare:2368Nebentan
CAS:<p>Nebentan (YM598) is an oral, selective ETA antagonist; Ki: 0.697 nM (ETA), 569 nM (ETB); may slow cor pulmonale, myocardial infarction.</p>Formula:C24H21N5O5SColore e forma:SolidPeso molecolare:491.52SB234551
CAS:SB234551 is a selective antagonist of endothelin ETA receptor.Formula:C34H34N2O9Colore e forma:SolidPeso molecolare:614.64IRL-3630
CAS:<p>IRL 3460 is an enantiomer.</p>Formula:C31H40N4O6SPurezza:98%Colore e forma:SolidPeso molecolare:596.74Sarafotoxin S6b
CAS:non-selective endothelin receptor agonistFormula:C110H163N27O34S5Purezza:98%Colore e forma:SolidPeso molecolare:2567.96Sarafotoxin S6c
CAS:<p>Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).</p>Formula:C103H147N27O37S5Purezza:98%Colore e forma:SolidPeso molecolare:2516PD 142893
CAS:PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.Formula:C50H65N7O10Purezza:98%Colore e forma:SolidPeso molecolare:924.09IRL-1620
CAS:<p>IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).</p>Formula:C86H117N17O27Purezza:98%Colore e forma:SolidPeso molecolare:1820.974Sarafotoxin S6a
CAS:Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.Formula:C105H156N28O34S5Purezza:98%Colore e forma:SolidPeso molecolare:2514.85BQ-123 TFA
BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.Formula:C33H43F3N6O9Colore e forma:SolidPeso molecolare:724.72[Ala2] Endothelin-3, human
CAS:<p>[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.</p>Formula:C120H166N26O32S4Colore e forma:SolidPeso molecolare:2613.02Endothelin 1 (swine, human), Alexa Fluor 488-labeled
<p>Synthetic human/swine Endothelin 1 peptide, tagged with Alexa Fluor 488, acts as a strong vasoconstrictor via ET A/B receptors.</p>Colore e forma:SolidPeso molecolare:2848.4[Lys4] Sarafotoxin S6c
CAS:[Lys4] Sarafotoxin S6c: potent partial endothelin receptor agonist; causes pig coronary contraction, EC50=1.5 nM.Formula:C105H153N27O36S5Colore e forma:SolidPeso molecolare:2529.82Endothelin-2 (49-69), human TFA
Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.Formula:C117H161N26F3O34S4Purezza:98%Colore e forma:SolidPeso molecolare:2660.94Methylsolfonyl 25(S)-Δ7-dafachronic acid
Methylsulfonyl 25(S)-Δ7-dafachronic acid (compound 3) is a selective ssDAF-12 agonist with an IC50 value of 0.41 μM. It exhibits low cytotoxicity in HepG2 cells, with an IC50 value greater than 200 μM. Methylsulfonyl 25(S)-Δ7-dafachronic acid is applicable in the study of parasitic diseases.Formula:C28H45NO4SPeso molecolare:491.30693Endothelin 1 (swine, human) (TFA)
CAS:Synthetic human/swine Endothelin 1 (TFA) peptide; a potent vasoconstrictor acting on ET A and ET B receptors.Formula:C111H160F3N25O34S5Peso molecolare:2605.93Bosentan-d4
CAS:Bosentan-d4: deuterium version of Bosentan, competitive ET A/B antagonist, Ki: 4.7nM (ET A), 95nM (ET B) in human SMC.Formula:C27H25D4N5O6SPeso molecolare:555.64ANP (1-30), frog
CAS:ANP (1-30), frog, a peptide fragment sourced from atrial natriuretic peptide of frog origin, exhibits natriuretic, diuretic, and vasorelaxant properties.Formula:C131H217N49O41S4Peso molecolare:3262.69Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
CAS:Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is an NPR-A agonist and ANP hormone. Carperitide increases cGMP levels and reduces the heart's workload.Formula:C129H207N45O41S3Purezza:99.78%Colore e forma:SoildPeso molecolare:3140.5IRL-1038 acetate
<p>IRL-1038 acetate is a potent ETB endothelin receptor antagonist.</p>Formula:C70H96N14O17S2Purezza:97.51%Colore e forma:SoildPeso molecolare:1469.73IRL-1038 TFA
<p>IRL-1038 TFA is an ETB receptor antagonist used in the study of cardiovascular disease.</p>Formula:C70H93F3N14O17S2Purezza:98.79%Colore e forma:SolidPeso molecolare:1523.7IRL-1620 acetate
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.Formula:C88H121N17O29Purezza:96.64%Colore e forma:SolidPeso molecolare:1881Atrial natriuretic peptide (3-28) (human)
CAS:Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation ofFormula:C118H187N43O36S3Purezza:98%Colore e forma:SolidPeso molecolare:2880.21Sulfatroxazole
CAS:Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of the ETA receptor with an IC50 of 0.26 μM.Formula:C11H13N3O3SColore e forma:SolidPeso molecolare:267.3BQ-3020 ammonium
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2Formula:C96H140N20O25S·xNH3Purezza:98%Colore e forma:SolidPeso molecolare:2006.32 (free base)Endothelin-3 (Rat,Human) (TFA)
<p>Endothelin-3 (Rat, Human) (TFA) is a 21-amino acid vasoactive peptide of endothelial origi, an agonist for the endothelin receptor type B (EDNRB).</p>Formula:C123H169F3N26O35S4·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:2757.07 (free base)Macitentan
CAS:<p>Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).</p>Formula:C19H20Br2N6O4SPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:588.27Sitaxsentan sodium
CAS:Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.Formula:C18H14ClN2O6S2·NaPurezza:98.39% - 99.01%Colore e forma:SolidPeso molecolare:476.89RO 46-8443
CAS:RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.Formula:C31H35N3O8SPurezza:98.77% - 99.77%Colore e forma:SolidPeso molecolare:609.69Atrasentan
CAS:Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.Formula:C29H38N2O6Purezza:97.65% - 99.08%Colore e forma:SolidPeso molecolare:510.62Sparsentan
CAS:Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,Formula:C32H40N4O5SPurezza:97.94% - 98.69%Colore e forma:SolidPeso molecolare:592.75BMS 182874 hydrochloride
CAS:BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.Formula:C17H20ClN3O3SPurezza:97.01%Colore e forma:SolidPeso molecolare:381.88Endothelin-2 (49-69), human
CAS:Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.Formula:C115H160N26O32S4Purezza:98.26%Colore e forma:SolidPeso molecolare:2546.92Ambrisentan
CAS:<p>Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.</p>Formula:C22H22N2O4Purezza:99.65% - 99.86%Colore e forma:SolidPeso molecolare:378.42Atrasentan sodium
CAS:Atrasentan (ABT-627) is an oral ETA receptor blocker with potential cancer-fighting properties, inhibiting angiogenesis and tumor growth.Formula:C29H37N2NaO6Colore e forma:SolidPeso molecolare:532.61Darusentan
CAS:Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteriesFormula:C22H22N2O6Purezza:98.72%Colore e forma:SolidPeso molecolare:410.43Ro 46-2005
CAS:Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).Formula:C23H27N3O6SPurezza:98.02% - 98.8%Colore e forma:SolidPeso molecolare:473.54Bosentan
CAS:Bosentan is a competitive endothelin receptor antagonist, used for treating pulmonary arterial hypertension.Formula:C27H29N5O6SPurezza:99.74% - 99.84%Colore e forma:Pale Yellow To Off-White SolidPeso molecolare:551.614ANP(1-28) Acetate (human, porcine)
CAS:<p>Carperitide acetate: 28-amino acid hormone from human heart, counters cardiac injury/stretch, reduces endothelin-1.</p>Formula:C129H207N45O41S3Purezza:98.24%Colore e forma:SolidPeso molecolare:3140.5Ambrisentan sodium
CAS:Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).Formula:C22H21N2NaO4Colore e forma:SolidPeso molecolare:400.41Aprocitentan
CAS:<p>Aprocitentan (ACT-132577) is ETA and ETB antagonist .</p>Formula:C16H14Br2N6O4SPurezza:99.17%Colore e forma:SolidPeso molecolare:546.19BQ-788 sodium salt
CAS:BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).Formula:C34H51N5NaO7Colore e forma:SolidPeso molecolare:664.8BQ-123
CAS:BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.Formula:C31H42N6O7Purezza:99.22% - ≥95%Colore e forma:SolidPeso molecolare:610.7Bosentan (hydrate)
CAS:Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.Formula:C27H29N5O6S·H2OPurezza:99.31% - 99.86%Colore e forma:White PowderPeso molecolare:569.63Nebentan potassium
CAS:Nebentan potassium (YM598) is an ETA receptor antagonist that inhibits pulmonary arterial hypertension and is used in the study of neurologic diseases.Formula:C24H20KN5O5SPurezza:99.05%Colore e forma:SolidPeso molecolare:529.61Zibotentan
CAS:Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.Formula:C19H16N6O4SPurezza:97.00% - 97.02%Colore e forma:SolidPeso molecolare:424.43Daglutril
CAS:Daglutril is a NEP/ECE inhibitor for treating hypertension, heart failure, and pulmonary issues, blocking big endothelin-1 conversion.Formula:C31H38N2O6Colore e forma:SolidPeso molecolare:534.64FR 139317
CAS:highly potent and selective ETA endothelin receptor antagonistFormula:C33H44N6O5Purezza:98%Colore e forma:SolidPeso molecolare:604.74Atrasentan hydrochloride
CAS:Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).Formula:C29H39ClN2O6Purezza:99.75%Colore e forma:SolidPeso molecolare:547.08WS 009A
CAS:WS 009A is an antagonist of the endothelin receptor.Formula:C24H25NO10SPurezza:98%Colore e forma:SolidPeso molecolare:519.52Avosentan
CAS:<p>Avosentan（Ro 67-0565; SPP-301） is a potent endothelin receptor (ETA) antagonist.Cost-effective and quality-assured.</p>Formula:C23H21N5O5SPurezza:98.31% - 99.47%Colore e forma:SolidPeso molecolare:479.51Aminaftone
CAS:<p>Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.</p>Formula:C18H15NO4Purezza:96.31% - 99.39%Colore e forma:SolidPeso molecolare:309.32TBC3711
CAS:TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders.Formula:C20H21N3O5S2Purezza:98%Colore e forma:SolidPeso molecolare:447.53ETA antagonist 1
CAS:ETA antagonist 1 is an antagonist of ETA selective (IC50 of 0.08 μM).Formula:C20H25N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:387.5ZD-1611
CAS:ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke.Formula:C22H24N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:456.51CH 141
CAS:CH 141 is a new type of peripheral vasodilator.Formula:C19H21N3OColore e forma:SolidPeso molecolare:307.39ABT-546
CAS:ABT-546 is a potent, selective endothelin ETA receptor antagonist, Ki 0.46 nM for [125I]ET-1 binding.Formula:C30H48N2O6Purezza:98%Colore e forma:SolidPeso molecolare:532.71BMS-193884
CAS:BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.Formula:C20H17N3O4SColore e forma:SolidPeso molecolare:395.43CI 1020
CAS:endothelin-A receptor (ETA) antagonistFormula:C28H26O9Purezza:98%Colore e forma:SolidPeso molecolare:506.5PD-156707
CAS:PD-156707 is a selective antagonist of endothelin A receptor.Formula:C28H26NaO9Purezza:98%Colore e forma:SolidPeso molecolare:529.497WS 009B
CAS:WS 009B is an antagonist of the endothelin receptor.Formula:C24H25NO11SPurezza:98%Colore e forma:SolidPeso molecolare:535.52PD-159020
CAS:PD-159020 is a non-selective antagonist of ETA/ETB(hETA and hETB with IC50s of 30 and 50 nM , respectively).Formula:C32H25NO8Purezza:98%Colore e forma:SolidPeso molecolare:551.54Sitaxsentan
CAS:Sitaxsentan (TBC-11251), a selective ETA receptor antagonist, prevents vasoconstriction by blocking endothelin.Formula:C18H15ClN2O6S2Purezza:97.99% - 98.71%Colore e forma:SolidPeso molecolare:454.9Edonentan
CAS:<p>Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.</p>Formula:C28H32N4O5SPurezza:98.07% - 99.6%Colore e forma:SolidPeso molecolare:536.64BMS 182874
CAS:BMS 182874: Oral ETA antagonist, IC50=0.150 μM, Ki=0.055 μM, lowers hypertension in rats.Formula:C17H19N3O3SPurezza:99.73%Colore e forma:SolidPeso molecolare:345.42SB-209670
CAS:SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.Formula:C29H28O9Purezza:98.29% - 99.40%Colore e forma:SolidPeso molecolare:520.53L-749329
CAS:L-749329 is a ligand of ET(A) and ET(B) endothelin receptor.Formula:C28H29NO8SPurezza:98%Colore e forma:SolidPeso molecolare:539.6Clazosentan
CAS:Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.Formula:C25H23N9O6SPurezza:95.39% - >99.99%Colore e forma:SolidPeso molecolare:577.57JKC 302
CAS:JKC 302 is an ET-A receptor antagonist that partially inhibits the contraction of tracheal rings in asthmatic rats induced by ET-1.Formula:C30H42N6O6Colore e forma:SolidPeso molecolare:582.69IRL 2500
CAS:IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.Formula:C36H35N3O4Purezza:99.36%Colore e forma:White Crystalline SolidPeso molecolare:573.68K-8794
CAS:<p>K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.</p>Formula:C36H38N6O6SColore e forma:SolidPeso molecolare:682.789Macitentan (n-butyl analogue)
CAS:Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.Formula:C20H21Br2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:587.29Tezosentan
CAS:Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).Formula:C27H27N9O6SPurezza:98%Colore e forma:SolidPeso molecolare:605.63BMS-248360
CAS:BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.Formula:C36H45N5O5SPurezza:98%Colore e forma:SolidPeso molecolare:659.84Diosuxentan
CAS:Diosuxentan is an inhibitor of ETA and is utilized in research pertaining to cardiovascular, renal, and neuronal inflammatory diseases.Formula:C20H21BrN6O7SColore e forma:SolidPeso molecolare:569.39BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Formula:C34H51N5O7Purezza:98.81%Colore e forma:SolidPeso molecolare:641.8Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purezza:98%Colore e forma:LiquidRef: TM-T81538
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