Recettore Sigma
I recettori sigma sono siti di legame unici che, a differenza dei tradizionali GPCR, non rientrano nelle categorie classiche delle proteine recettoriali. Sono coinvolti nella modulazione dei sistemi di neurotrasmettitori e sono stati implicati in vari disturbi neurologici e psichiatrici. I recettori sigma sono anche associati alla sopravvivenza cellulare, e i loro ligandi vengono esplorati per applicazioni terapeutiche nella neuroprotezione, nel cancro e nella gestione del dolore. Presso CymitQuimica, offriamo una selezione di modulatori dei recettori sigma di alta qualità per supportare la tua ricerca in neuroscienze, oncologia e biologia dei recettori.
Trovati 46 prodotti di "Recettore Sigma"
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Roluperidone
CAS:<p>Roluperidone (CYR-101) is a novel cyclic amide derivative.</p>Formula:C22H23FN2O2Purezza:96.46% - 97.77%Colore e forma:SolidPeso molecolare:366.43Glycerol phenylbutyrate
CAS:Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Formula:C33H38O6Purezza:98.54% - 99.74%Colore e forma:SolidPeso molecolare:530.65Blonanserin
CAS:Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.Formula:C23H30FN3Purezza:99.85%Colore e forma:SolidPeso molecolare:367.5AD353
AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.Formula:C23H30N2O2Colore e forma:SolidPeso molecolare:366.5σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Formula:C22H28N2O2Colore e forma:SolidPeso molecolare:352.47PD 144418 oxalate
CAS:<p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>Formula:C20H24N2O5Purezza:98.76%Colore e forma:SolidPeso molecolare:372.42KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Formula:C24H32N2O8Purezza:98.12%Colore e forma:SolidPeso molecolare:476.52UKH-1114
CAS:UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.Formula:C22H24F3NOColore e forma:SolidPeso molecolare:375.43AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Formula:C25H30N2O5Purezza:98%Colore e forma:SolidPeso molecolare:438.52Sigma-1 receptor antagonist 4
<p>Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced</p>Formula:C22H26N2OColore e forma:SolidPeso molecolare:334.45σ1R-IN-1
σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.Formula:C15H22N2Colore e forma:SolidPeso molecolare:230.35AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.Formula:C22H28N2Purezza:98%Colore e forma:SolidPeso molecolare:320.47AB21 HCl
AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.Formula:C23H29ClN2OPurezza:99.91%Colore e forma:SolidPeso molecolare:384.2S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.Formula:C21H28ClNOPurezza:98%Colore e forma:SolidPeso molecolare:345.914-IBP
CAS:4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .Formula:C19H21IN2OPurezza:98.99%Colore e forma:SolidPeso molecolare:420.29Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Formula:C19H24ClNOPurezza:99.57% - 99.9%Colore e forma:SolidPeso molecolare:317.85Cutamesine dihydrochloride
CAS:<p>Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.</p>Formula:C23H32N2O2·2HClPurezza:99.96%Colore e forma:SolidPeso molecolare:441.43σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Formula:C21H23NOSPurezza:99.8%Colore e forma:SolidPeso molecolare:337.48BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Formula:C15H24Br2Cl2N2Purezza:97.81%Colore e forma:SolidPeso molecolare:463.08PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Formula:C19H28ClNO3Purezza:99.54%Colore e forma:SolidPeso molecolare:353.88
