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CaSR

CaSR

Il recettore sensibile al calcio (CaSR) è un GPCR che svolge un ruolo vitale nel mantenimento dell'omeostasi del calcio regolando la secrezione dell'ormone paratiroideo e il riassorbimento del calcio nei reni. Il CaSR è anche coinvolto in vari altri processi fisiologici, tra cui il metabolismo osseo e la funzione vascolare. I modulatori del CaSR sono utilizzati nel trattamento di condizioni come l'iperparatiroidismo, l'osteoporosi e le malattie cardiovascolari. Presso CymitQuimica, offriamo una selezione di modulatori del CaSR di alta qualità per supportare la tua ricerca nel metabolismo del calcio, endocrinologia e salute delle ossa.

Trovati 34 prodotti di "CaSR"

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  • γ-L-Glutamyl-L-alanine
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    γ-L-Glutamyl-L-alanine

    CAS:
    γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).
    Formula:C8H14N2O5
    Purezza:99.49%
    Colore e forma:Solid
    Peso molecolare:218.21

    Ref: TM-T7507

  • Poly-D-lysine hydrobromide (MW 30000-70000)
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    Poly-D-lysine hydrobromide (MW 30000-70000)

    CAS:
    Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.
    Formula:(C6H14N2O2)x·xHBr
    Colore e forma:Solid
    Peso molecolare:227.102

    Ref: TM-T40363

  • NPS-2143
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    NPS-2143

    CAS:
    NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.
    Formula:C24H25ClN2O2
    Purezza:99.56%
    Colore e forma:Solid
    Peso molecolare:408.92

    Ref: TM-T1730

  • (Rac)-Upacicalcet
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    (Rac)-Upacicalcet

    CAS:
    <p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>
    Formula:C11H14ClN3O6S
    Colore e forma:Solid
    Peso molecolare:351.76

    Ref: TM-T61232

  • Calhex 231 hydrochloride
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    Calhex 231 hydrochloride

    CAS:
    Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .
    Formula:C25H28Cl2N2O
    Purezza:99.36%
    Colore e forma:Solid
    Peso molecolare:443.41

    Ref: TM-T10666

  • Tecalcet Hydrochloride
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    Tecalcet Hydrochloride

    CAS:
    <p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>
    Formula:C18H23Cl2NO
    Purezza:99.97%
    Colore e forma:Solid
    Peso molecolare:340.29

    Ref: TM-T13918

  • GSK3004774
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    GSK3004774

    CAS:
    <p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>
    Formula:C32H40N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:528.68

    Ref: TM-T11493

  • Ronacaleret HCl
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    Ronacaleret HCl

    CAS:
    Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.
    Formula:C25H32ClF2NO4
    Purezza:99.97%
    Colore e forma:Solid
    Peso molecolare:483.98

    Ref: TM-T34385

  • CaSR antagonist-1
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    CaSR antagonist-1

    CAS:
    CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation
    Formula:C29H24FN3O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:497.58

    Ref: TM-T79023

  • Encaleret
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    Encaleret

    CAS:
    Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.
    Formula:C29H33ClFNO4
    Colore e forma:Solid
    Peso molecolare:514.03

    Ref: TM-T31624

  • Calindol hydrochloride
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    Calindol hydrochloride

    CAS:
    <p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>
    Formula:C21H21ClN2
    Purezza:99.47%
    Colore e forma:Solid
    Peso molecolare:336.86

    Ref: TM-T21758

  • H-Glu-Thr-OH
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    H-Glu-Thr-OH

    CAS:
    H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).
    Formula:C9H16N2O6
    Colore e forma:Solid
    Peso molecolare:248.23

    Ref: TM-T201727

  • TAK-075
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    TAK-075

    CAS:
    <p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>
    Formula:C36H46N4O4S
    Colore e forma:Solid
    Peso molecolare:630.84

    Ref: TM-T206506

  • SB-423562
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    SB-423562

    CAS:
    SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.
    Formula:C26H32N2O4
    Purezza:99.22%
    Colore e forma:Solid
    Peso molecolare:436.54

    Ref: TM-T12846