CaSR
Il recettore sensibile al calcio (CaSR) è un GPCR che svolge un ruolo vitale nel mantenimento dell'omeostasi del calcio regolando la secrezione dell'ormone paratiroideo e il riassorbimento del calcio nei reni. Il CaSR è anche coinvolto in vari altri processi fisiologici, tra cui il metabolismo osseo e la funzione vascolare. I modulatori del CaSR sono utilizzati nel trattamento di condizioni come l'iperparatiroidismo, l'osteoporosi e le malattie cardiovascolari. Presso CymitQuimica, offriamo una selezione di modulatori del CaSR di alta qualità per supportare la tua ricerca nel metabolismo del calcio, endocrinologia e salute delle ossa.
Trovati 31 prodotti per "CaSR".
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(Rac)-Upacicalcet
CAS:(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.Formula:C11H14ClN3O6SColore e forma:SolidPeso molecolare:351.76GSK3004774
CAS:GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.Formula:C32H40N4O3Purezza:98%Colore e forma:SolidPeso molecolare:528.68Tecalcet Hydrochloride
CAS:Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.Formula:C18H23Cl2NOPurezza:99.97%Colore e forma:White SolidPeso molecolare:340.29Ref: TM-T13918
200mgPrezzo su richiesta2mg34,00€5mg47,00€1mL*10mM (DMSO)52,00€10mg72,00€25mg146,00€50mg230,00€100mg335,00€Ronacaleret HCl
CAS:Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.Formula:C25H32ClF2NO4Purezza:99.97%Colore e forma:SolidPeso molecolare:483.98CaSR antagonist-1
CAS:CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigationFormula:C29H24FN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:497.58Encaleret
CAS:Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.Formula:C29H33ClFNO4Colore e forma:SolidPeso molecolare:514.03Calindol hydrochloride
CAS:Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.Formula:C21H21ClN2Purezza:99.84%Colore e forma:SolidPeso molecolare:336.86H-Glu-Thr-OH
CAS:H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).Formula:C9H16N2O6Colore e forma:SolidPeso molecolare:248.23TAK-075
CAS:TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.Formula:C36H46N4O4SColore e forma:SolidPeso molecolare:630.84Encaleret sodium
CAS:Encaleret (CLTX-305) sodium is an orally active calcium-sensing receptor (CaSR) antagonist with an IC50 of 12 nM. It functions by inhibiting the excessive activity of gain-of-function CaSR variants, helping to restore blood calcium levels, promote parathyroid hormone secretion, and improve magnesium and phosphorus metabolism along with urinary calcium excretion. Encaleret sodium is applicable in the research of conditions such as osteoporosis and autosomal dominant hypocalcemia type 1.Formula:C29H34ClFNNaO4Peso molecolare:538.03SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Formula:C26H32N2O4Purezza:99.22%Colore e forma:SolidPeso molecolare:436.54
