PKA
La proteina chinasi A (PKA) è un enzima chiave nella cascata di segnalazione dei GPCR, attivato dall'AMP ciclico (cAMP) in risposta a vari segnali extracellulari. La PKA regola una vasta gamma di processi cellulari, tra cui il metabolismo, l'espressione genica e la crescita cellulare. La disregolazione dell'attività della PKA è associata a varie malattie, tra cui il cancro, i disturbi metabolici e le condizioni cardiovascolari. I modulatori della PKA sono strumenti preziosi nella ricerca volta a comprendere le vie di segnalazione dei GPCR e a sviluppare nuove strategie terapeutiche. Presso CymitQuimica, offriamo una selezione di modulatori della PKA di alta qualità per supportare la tua ricerca nella trasduzione del segnale, nella regolazione cellulare e nei meccanismi delle malattie.
Trovati 51 prodotti di "PKA"
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Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Formula:C8H11NO3·C5H7NO3Purezza:99.19%Colore e forma:Off-White PowderPeso molecolare:298.29H-8 hydrochloride
CAS:H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Formula:C12H17Cl2N3O2SPurezza:99.93%Colore e forma:White To Off-White Crystalline SolidPeso molecolare:338.256-Bn-cAMP
CAS:<p>6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.</p>Formula:C17H18N5O6PColore e forma:SolidPeso molecolare:419.338-MA-cAMP
CAS:8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.Formula:C11H15N6O6PColore e forma:SolidPeso molecolare:358.258-Chloro-cAMP sodium
CAS:8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.Formula:C10H10ClN5NaO6PColore e forma:SolidPeso molecolare:385.63Rp-cAMPS triethylammonium salt
CAS:<p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>Formula:C16H27N6O5PSPurezza:98%Colore e forma:SolidPeso molecolare:446.46BGC201531
CAS:<p>BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.</p>Formula:C26H28N2O6SPurezza:98.51% - 99.33%Colore e forma:SolidPeso molecolare:496.58Protein kinase inhibitor 7
CAS:Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Formula:C12H15N3O2SPeso molecolare:265.33FMP-API-1
CAS:FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).Formula:C13H14N2O2Colore e forma:SolidPeso molecolare:230.2628-Br-cGMP-AM
CAS:<p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>Formula:C13H15BrN5O9PColore e forma:SolidPeso molecolare:496.16PET-cGMP
CAS:<p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>Formula:C18H16N5O7PColore e forma:SolidPeso molecolare:445.323
