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PKA

PKA

La proteina chinasi A (PKA) è un enzima chiave nella cascata di segnalazione dei GPCR, attivato dall'AMP ciclico (cAMP) in risposta a vari segnali extracellulari. La PKA regola una vasta gamma di processi cellulari, tra cui il metabolismo, l'espressione genica e la crescita cellulare. La disregolazione dell'attività della PKA è associata a varie malattie, tra cui il cancro, i disturbi metabolici e le condizioni cardiovascolari. I modulatori della PKA sono strumenti preziosi nella ricerca volta a comprendere le vie di segnalazione dei GPCR e a sviluppare nuove strategie terapeutiche. Presso CymitQuimica, offriamo una selezione di modulatori della PKA di alta qualità per supportare la tua ricerca nella trasduzione del segnale, nella regolazione cellulare e nei meccanismi delle malattie.

Trovati 58 prodotti per "PKA".

prodotti per pagina.
  • Bilobetin
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    Bilobetin

    CAS:
    Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
    Formula:C31H20O10
    Purezza:97% - 99.69%
    Colore e forma:Yellow Solid
    Peso molecolare:552.4845

    Ref: TM-T4S2128

  • PKG Substrate acetate
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    PKG Substrate acetate

    PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a
    Formula:C37H71N17O13
    Purezza:99.94%
    Colore e forma:Solid
    Peso molecolare:962.08

    Ref: TM-TP1787L

  • Hydroxyfasudil
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    Hydroxyfasudil

    CAS:
    Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
    Formula:C14H17N3O3S
    Purezza:98.13%
    Colore e forma:White Solid
    Peso molecolare:307.368

    Ref: TM-T4276L

  • Malantide acetate
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    Malantide acetate

    Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide
    Formula:C74H128N22O23
    Purezza:>99.99%
    Colore e forma:Solid
    Peso molecolare:1693.97

    Ref: TM-TP1789L

  • CCG215022
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    CCG215022

    CAS:
    CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.
    Formula:C26H22FN7O3
    Purezza:97.63% - 99.69%
    Colore e forma:Solid
    Peso molecolare:499.4964

    Ref: TM-T3498

  • Daphnetin
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    Daphnetin

    CAS:
    Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
    Formula:C9H6O4
    Purezza:97.47% - 99.95%
    Colore e forma:Solid
    Peso molecolare:178.1415

    Ref: TM-T2851

  • PKG drug G1
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    PKG drug G1

    CAS:
    PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
    Formula:C13H11N3OS
    Purezza:97.57% - 97.67%
    Colore e forma:Solid
    Peso molecolare:257.311

    Ref: TM-T4661

  • Iso-H7 dihydrochloride
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    Iso-H7 dihydrochloride

    CAS:
    Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.
    Formula:C14H19Cl2N3O2S
    Purezza:99.53%
    Colore e forma:White Crystalline Solid
    Peso molecolare:364.291

    Ref: TM-T7501

  • CREBtide acetate
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    CREBtide acetate

    CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
    Formula:C75H133N29O21
    Purezza:96.13%
    Colore e forma:Solid
    Peso molecolare:1777.07

    Ref: TM-TP1876L

  • PKI 14-22 amide, myristoylated Acetate
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    PKI 14-22 amide, myristoylated Acetate

    PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. 
    Formula:C55H104N20O14
    Purezza:96.34%
    Colore e forma:Solid
    Peso molecolare:1269.54

    Ref: TM-T21983L

  • HA-100
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    HA-100

    CAS:
    HA-100 is an inhibitor of protein kinase
    Formula:C13H15N3O2S
    Purezza:99.44%
    Colore e forma:White Solid
    Peso molecolare:277.34

    Ref: TM-T7648

  • PKG inhibitor peptide TFA
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    PKG inhibitor peptide TFA

    PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).
    Formula:C40H75F3N18O12
    Purezza:98% - 98.92%
    Colore e forma:White Solid
    Peso molecolare:1057.13

    Ref: TM-TP1523

  • PKI (5-24) Acetate
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    PKI (5-24) Acetate

    PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).
    Formula:C96H152N32O33
    Purezza:99.47%
    Colore e forma:Solid
    Peso molecolare:2282.43

    Ref: TM-TP1957L

  • H-8 hydrochloride
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    H-8 hydrochloride

    CAS:
    H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.
    Formula:C12H17Cl2N3O2S
    Purezza:99.84%
    Colore e forma:Solid
    Peso molecolare:338.253

    Ref: TM-T22832

  • WAY-299562
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    WAY-299562

    CAS:
    WAY-299562 is a modulator that regulates the interaction between protein kinase A (PKA) and A-kinase anchoring proteins (AKAP).
    Formula:C16H13NO3
    Colore e forma:Solid
    Peso molecolare:267.28

    Ref: TM-T202170

  • BGC201531
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    BGC201531

    CAS:
    BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.
    Formula:C26H28N2O6S
    Purezza:98.51% - 99.33%
    Colore e forma:White Solid
    Peso molecolare:496.58

    Ref: TM-T8993

  • Protein kinase inhibitor 7
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    Protein kinase inhibitor 7

    CAS:
    Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.
    Formula:C12H15N3O2S
    Colore e forma:Solid
    Peso molecolare:265.33

    Ref: TM-T210123

  • FMP-API-1
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    FMP-API-1

    CAS:
    FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).
    Formula:C13H14N2O2
    Colore e forma:Solid
    Peso molecolare:230.262

    Ref: TM-T204439