PKA
La proteina chinasi A (PKA) è un enzima chiave nella cascata di segnalazione dei GPCR, attivato dall'AMP ciclico (cAMP) in risposta a vari segnali extracellulari. La PKA regola una vasta gamma di processi cellulari, tra cui il metabolismo, l'espressione genica e la crescita cellulare. La disregolazione dell'attività della PKA è associata a varie malattie, tra cui il cancro, i disturbi metabolici e le condizioni cardiovascolari. I modulatori della PKA sono strumenti preziosi nella ricerca volta a comprendere le vie di segnalazione dei GPCR e a sviluppare nuove strategie terapeutiche. Presso CymitQuimica, offriamo una selezione di modulatori della PKA di alta qualità per supportare la tua ricerca nella trasduzione del segnale, nella regolazione cellulare e nei meccanismi delle malattie.
Trovati 51 prodotti di "PKA"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PKA/AKAP-IN-2
CAS:PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Formula:C17H17NO3Purezza:99.82%Colore e forma:SoildPeso molecolare:283.32Malantide TFA
<p>Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.</p>Formula:C74H125F3N22O23Colore e forma:SolidPeso molecolare:1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS:H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].Formula:C31H58N14O9Colore e forma:SolidPeso molecolare:770.88AP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Formula:C18H16N4SPurezza:99.87%Colore e forma:SoildPeso molecolare:320.41PKI (5-24),amide
CAS:PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.Formula:C94H149N33O30Colore e forma:SolidPeso molecolare:2221.4DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Formula:C152H258N52O28S·xC2H4O2Colore e forma:SolidPeso molecolare:3294.07 (free acid)Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formula:C17H16ClN3OPurezza:98.04% - ≥95%Colore e forma:SolidPeso molecolare:313.78Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormula:C28H26N4O3Purezza:99.24% - 99.82%Colore e forma:Off-White PowderPeso molecolare:466.538-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Formula:C10H10BrN5NaO6PPurezza:98% - 99.94%Colore e forma:Off-White PowderPeso molecolare:430.08Iso-H7 dihydrochloride
CAS:Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formula:C14H19Cl2N3O2SPurezza:99.53%Colore e forma:White Crystalline SolidPeso molecolare:364.29CCG215022
CAS:<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Formula:C26H22FN7O3Purezza:97.63% - 99.69%Colore e forma:SolidPeso molecolare:499.5AT7867
CAS:<p>AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.</p>Formula:C20H20ClN3Purezza:99.63%Colore e forma:SolidPeso molecolare:337.85Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Formula:C31H20O10Purezza:97.74% - 99.69%Colore e forma:SolidPeso molecolare:552.48PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Formula:C82H134N28O26Purezza:99.30%Colore e forma:SolidPeso molecolare:1928.11Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formula:C14H19Cl2N3O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:364.29HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Formula:C13H15N3O2SPurezza:99.44%Colore e forma:Pale Yellow Crystalline SolidPeso molecolare:277.34PKG drug G1
CAS:PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Formula:C13H11N3OSPurezza:97.57% - 97.67%Colore e forma:SolidPeso molecolare:257.31H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Formula:C20H20BrN3O2S·2HClPurezza:98.22% - >99.99%Colore e forma:SolidPeso molecolare:519.28
