Proteina Hedgehog/Smoothened
La via di segnalazione Hedgehog/Smoothened è una via correlata ai GPCR cruciale, coinvolta nello sviluppo embrionale, nella rigenerazione dei tessuti e nel mantenimento delle cellule staminali. Smoothened (SMO) è una proteina transmembrana chiave che trasduce i segnali dai ligandi Hedgehog (Hh) per attivare le cascate di segnalazione a valle. La disregolazione della via Hedgehog/Smoothened è implicata in vari tumori e disturbi dello sviluppo, rendendola un bersaglio significativo per l'intervento terapeutico. Presso CymitQuimica, offriamo una gamma di modulatori di alta qualità per la via Hedgehog/Smoothened per supportare la tua ricerca in biologia dello sviluppo, oncologia e medicina rigenerativa.
Trovati 49 prodotti di "Proteina Hedgehog/Smoothened"
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MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formula:C31H29N3O5SPurezza:99.72%Colore e forma:SolidPeso molecolare:555.64SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Formula:C28H28ClN3OSPurezza:97.37% - 98.88%Colore e forma:SolidPeso molecolare:490.06Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Formula:C17H9Cl2N3O2Purezza:98.54% - 99.57%Colore e forma:SolidPeso molecolare:358.18HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formula:C27H29NO6Purezza:97.6%Colore e forma:SolidPeso molecolare:463.52Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Formula:C27H21ClN2O3Purezza:98.01%Colore e forma:SolidPeso molecolare:456.925-LOX inhibitor
CAS:5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Formula:C22H27N5O2Purezza:98.01%Colore e forma:SolidPeso molecolare:393.48MS-0022
CAS:MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Formula:C21H16BrN3OColore e forma:SolidPeso molecolare:406.28SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formula:C16H24BrClN2OPurezza:99.81%Colore e forma:SolidPeso molecolare:375.733-epi-Vitamin D3
CAS:3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFormula:C27H44OColore e forma:SolidPeso molecolare:384.64RUSKI-201 dihydrochloride
CAS:RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Formula:C20H29Cl2N3OSColore e forma:SolidPeso molecolare:430.43Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Formula:C23H15ClF4N4O2Colore e forma:SolidPeso molecolare:490.84SMO-IN-3
CAS:SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Formula:C27H25F4N3O2Colore e forma:SolidPeso molecolare:499.5RUSKI-201
CAS:RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Formula:C20H27N3OSColore e forma:SolidPeso molecolare:357.51SANT-2
CAS:SANT-2 is a potent inhibitor of Shh signaling pathway.Formula:C23H20ClN3O4Colore e forma:SolidPeso molecolare:437.88Hedgehog IN-3
CAS:Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Formula:C18H13ClF3N5OColore e forma:SolidPeso molecolare:407.78M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Formula:C23H29N3O2Colore e forma:SolidPeso molecolare:379.5LEQ-506
CAS:LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Formula:C27H29N5OColore e forma:SolidPeso molecolare:439.55SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Formula:C25H25F4N5O2Purezza:98.64%Colore e forma:SolidPeso molecolare:503.49AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formula:C25H24N4O2Purezza:99.96%Colore e forma:SolidPeso molecolare:412.48Hedgehog IN-2
CAS:Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Formula:C24H22N4O2Colore e forma:SolidPeso molecolare:398.46
