Proteina Hedgehog/Smoothened
La via di segnalazione Hedgehog/Smoothened è una via correlata ai GPCR cruciale, coinvolta nello sviluppo embrionale, nella rigenerazione dei tessuti e nel mantenimento delle cellule staminali. Smoothened (SMO) è una proteina transmembrana chiave che trasduce i segnali dai ligandi Hedgehog (Hh) per attivare le cascate di segnalazione a valle. La disregolazione della via Hedgehog/Smoothened è implicata in vari tumori e disturbi dello sviluppo, rendendola un bersaglio significativo per l'intervento terapeutico. Presso CymitQuimica, offriamo una gamma di modulatori di alta qualità per la via Hedgehog/Smoothened per supportare la tua ricerca in biologia dello sviluppo, oncologia e medicina rigenerativa.
Trovati 49 prodotti di "Proteina Hedgehog/Smoothened"
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GSA-10
CAS:GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Formula:C26H30N2O5Purezza:99.71%Colore e forma:SolidPeso molecolare:450.53Hh-Ag1.5
CAS:Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formula:C28H26ClF2N3OSPurezza:99.8%Colore e forma:SolidPeso molecolare:526.04Ref: TM-T24754
1mg127,00€5mg305,00€10mg472,00€25mg782,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)354,00€Robotnikinin
CAS:Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.Formula:C25H27ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:454.95SAG 21k
CAS:SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formula:C29H28ClF2N3O2SPurezza:99.51%Colore e forma:SolidPeso molecolare:556.07TAK-441
CAS:TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formula:C28H31F3N4O6Purezza:99.82%Colore e forma:SolidPeso molecolare:576.56IMP-1575
CAS:IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.Formula:C19H25N3OSPeso molecolare:343.49MRT-92
CAS:MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.Formula:C33H34N4O5Colore e forma:SolidPeso molecolare:566.65BRD50837
CAS:BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).Formula:C26H32ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.07LAB687
CAS:LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.Formula:C26H23F3N2O3Colore e forma:SolidPeso molecolare:468.47
