Antibatterico

Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.

Cefotiam dihydrochloride hydrate: parenteral cephalosporin antibiotic with broad-spectrum Gram-positive and Gram-negative activity.

CjGlmU, a sugar nucleotidyltransferase, uses UTP and GlcNAc-1-P to make UDP-GlcNAc, and has antimicrobial research potential.

HLF1-11: human lactoferrin peptide, antimicrobial, inhibits MPO, steers monocytes to macrophages, boosts immunity.

Lactoferricin H, Lactotransferrin (37-61), human, is a bioactive peptide with antimicrobial properties, derived from the amino acid residues 37-61 of human

Aurein 1.1, an antibiotic peptide, originates from Australian Bell Frogs (Litoria raniformis) [1].

Bovine tracheal antimicrobial peptide, derived from the tracheal mucosa, exhibits antimicrobial efficacy against E.

Diaporthein B, a potent pimarane diterpene, inhibits M. tuberculosis (MIC: 3.1 μg/mL) and combats colon cancer cells (IC50: 1.5-3 μM/L).

Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.

Netropsin: polypeptide from Streptomyces, with antibiotic/antiviral properties, binds to A-T DNA regions, effective on Gram-positive/negative bacteria.

PBP4-IN-1 (Compound 1) is an inhibitor targeting penicillin-binding protein 4 (PBP4) in Staphylococcus aureus. By inhibiting the function of PBP4, PBP4-IN-1 enhances the antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) mediated by PBP2a. This compound is used in studies involving osteomyelitis caused by Staphylococcus aureus and in research aimed at reversing PBP4-mediated resistance to β-lactam antibiotics.

Julifloricine is an alkaloid isolated from Prosopis juliflora that has antimicrobial activity.

Altromycin A is an anticancer agent.

G43 inhibits glucosyltransferase GtfB (Kd 3.7μM) and GtfC (Kd 46.9nM), and fights Streptococcus mutans in caries research.

Bombinin H7, an antimicrobial peptide originating from the skin secretions of Bombina, exhibits bactericidal activity against Bacillus megaterium Bm11 at a

TP2 inhibits Pks13, halting mycolic acid production and killing mycobacteria, with a 1 μM MIC against Mycobacterium tuberculosis.

Pks13-IN-1 (Compound 44) is an orally active inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13). It inhibits the M. tuberculosis H37Rv strain with a minimum inhibitory concentration (MIC) of 0.07 μM. In mouse models, Pks13-IN-1 demonstrates antibacterial activity.

Myricetin 3-O-α-L-arabinopyranoside, a quercetin derivative and plant flavonoid, exhibits antioxidant, antibacterial, and antiurease properties.

Antibacterial agent 165 (compound 3), a hydroxyquinoline derivative, effectively inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1], demonstrating

Pelagiomicin A is used as an anticancer antibiotic produced by the marine bacterium Pelagiobacter variabilis.

Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.

Cefoperazone dihydrate, a semi-synthetic cephalosporin, exhibits a wide range of antibacterial properties.

Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.

Cephalexin: potent oral antibiotic, broad-spectrum against gram-positive/negative bacteria; treats pneumonia, strep throat, endocarditis.

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

Flurithromycin is an orally active, broad-spectrum antibiotic for bacterial infection research.

Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.

Angustifoline HCl, from Lupinus angustifolius, has antimicrobial effects on S. aureus, B. subtilis, E. coli, P. aeruginosa, B. thuringiensis.

Fortimicin C is a bioactive chemical.

"Ribostamycin (Vistamycin) is a broad-spectrum antibiotic, effective against many bacteria and inhibits PDI."

NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.

Arylomycin A4 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

Antibacterial agent 55 (example 21) is a antibacterial agent.

Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.

Temporin C is an antimicrobial peptide effective against Legionella pneumophila [1].

Sitafloxacin (DU6859a) is a potent fluoroquinolone, effective against a wide spectrum of bacteria and used for respiratory and urinary infections.

Nybomycin, a fungal metabolite from Streptomyces sp. A717, has antibacterial properties; effective against various bacteria including M. tuberculosis.

Naphthomycin B is an antibiotic that was originally isolated from Streptomyces sp. It exhibits antibacterial activity against gram-positive bacteria and various fungi.

Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.

EBL-3183 is a reversible, competitive indole-2-carboxylate NDM-1 inhibitor with a pIC50 of 7.7, targeting metallo-β-lactamases.

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins

Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent.

Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.

Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.

Betonicine, an l-alpha-amino acid, is in herbs, spices, pulses, and mainly urine.

Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.

Valclavam is a biochemical.

Compound 1h (Antibacterial agent 108) is a potent antibacterial agent, demonstrating a minimum inhibitory concentration (MIC) of 3 μM against both MRSA and

Apigravin, a potent antibacterial compound, demonstrates activity against Bacillus subtilis, exhibiting a minimum inhibitory concentration (MIC) value of 61 μM

Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A.

Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.

UX4O is an allosteric inhibitor of UDP-glucose dehydrogenase (UGDH). The human UGDH (hUGDH) is a hexamer that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid. It exists in an active (E) state and an inactive (EΩ) state, which requires binding with the allosteric inhibitor UDP-xylose (UDP-Xyl) to stabilize the inactive form. UX4O may also serve as a physiologically relevant inhibitor of bacterial allosteric UGDH that does not produce UDP-Xyl.

Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.

Dalbavancin HCl (MDL-63397 HCl), a semi-synthetic antibiotic, targets Gram-positive bacteria with low MICs for S. aureus and B. anthracis.

A-54556B: Natural ADEP antibiotic from S. hawaiiensis, combats Gram-positive and anaerobic bacteria, including penicillin-resistant S. aureus.

Thanatin is an antimicrobial peptide with antifungal properties effective against certain Gram-positive bacteria [1].

Pyrindamycin B is an antibiotic,and actives against gram-positive and gram-negative bacterias

LL-BM123γ2 is an antimicrobial agent that exhibits activity against various microorganisms. It is utilized in research related to antimicrobial properties.

D-Hexamannuronic acid: alginate from brown algae & some bacteria, used in pain and dementia research.

Kyotorphin is a Morphine-like dipeptide.

(-)-cis-Myrtanol, a terpenoid compound derived from Artemisia dracunculus, exhibits effective antimicrobial activity against harmful gut bacteria such as Bifidobacterium bifidum.

Psoracorylifol C is a useful organic compound for research related to life sciences and the catalog number is T124015.

Emeguisin A, a depsidone from E. unguis, fights S. aureus, MRSA, C. neoformans (MIC 0.5 μg/ml), and P. falciparum (IC50 2.2 μM).

Cethromycin (ABT-773) is an antibiotic of ketolide.

KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2, with an IC50 value of 8.3 nM. KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems, leading to significant bacterial resistance to carbapenem antibiotics.

Ecteinascidin-Analog-1, a tetrahydroisoquinoline, is key for synthesizing ecteinascidin analogs with antitumor and antimicrobial properties.

Mtb-IN-5 (compound (-)17j) is an isoxazole exhibiting anti-Mycobacterium tuberculosis (Mtb) activity.

A 83016A is a kinamycin-type antibiotic.

Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.

Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).

Lysobactin (katanosin B) is an antibiotic effective against S. aureus, S. pneumoniae, and blocks PG biosynthesis.

BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus.

JSF-4898 is an orally bioactive inhibitor of Mycobacterium tuberculosis MenG enzyme. It exhibits a minimum inhibitory concentration (MIC) of 0.78 μM against Mycobacterium tuberculosis H37Rv. Additionally, JSF-4898 enhances the efficacy of rifampicin in a subacute infection model of Mycobacterium tuberculosis in mice.

XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.

A unique collection of xnum anti-infective compounds including anti-bacterial, anti-fungi, anti-Human Cytomegalovirus (HCMV), anti-HIV, anti-SARS, anti-

Anti gram-positive/negative bacteria agent 1 is an antibiotic linked with a synthetic MECAM-based siderophore, serving as a conjugate aimed at combating gram-

Aurein 5.2 is an antibiotic antimicrobial peptide [1].

HDAC3/8 ligand-1 (compound 40) serves as a ligand for the target protein of PROTAC, utilized in the synthesis of YX968.

Paldimycin B is a semi-synthetic antibiotic.

Maximin H2, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory effects on a range

Menaquinone 6, an active product found in *Wolinella succinogenes*, is a form of vitamin K2 with antimicrobial activity [1].

Lysolipin I is a bioactive chemical.

Nyssoside, an ellagic acid derivative, exhibits notable antioxidant and antibacterial properties against a variety of pathogenic bacteria.

BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae

Ro 25-0534 is an antipseudomonal dual-action drug with antimicrobial activity.

Antimicrobial agent-12 serves as a powerful antibacterial compound that also exhibits inhibitory activity against SARS-CoV-2 [1].

Calcium lactate (Conclyte) fortifies juice with calcium and aids soybean sprout growth and phytic acid breakdown.

(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic active against gram-negative pathogens, useful for studying resistant infections.

Phanerosporic acid, from P. chrysosporum, fights bacteria like B. cereus and fungi including C. cladosporioides; used in macrolide synthesis.

Antibacterial agent 54 (example 20) is a antibacterial agent.

Ilicicolin F is a useful organic compound for research related to life sciences. The catalog number is T125283 and the CAS number is 22738-98-3.

NL3 is an inhibitor of bacterial cystathionine gamma-lyase, exhibiting IC50 values of 0.7 μM for [bCSE] and 3.4 μM for [hCSE]. It is applicable in research focused on antibacterial activity and overcoming bacterial resistance.

Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd of 7 nM. This compound exhibits antimicrobial activity, with minimum inhibitory concentration (MIC) values of 0.2 μM against Staphylococcus aureus (including MRSA and MSSA) and 20 μM against Mycobacterium tuberculosis.

Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.

Tropodithietic acid, a sulfur-based antibiotic from Phaeobacter inhibens, targets many bacteria types.

Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.

Bio-AMS (TFA) inhibits bacterial biotin protein ligase, targets M. tuberculosis, and stops fatty acid/lipid synthesis.

6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.

ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.

(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].

Baquiloprim: an antibiotic that inhibits bacterial dihydrofolate reductases; fights Gram-negative and Gram-positive bacteria.

Maximin H4, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory activity against a

Saptomycin D, an antibiotic (antibiotic) isolated from the Streptomyces sp. HP530 strain, exhibits potent antitumor activity. It demonstrates strong inhibitory effects on Gram-positive bacteria and weaker inhibition against certain Gram-negative bacteria and yeasts. Additionally, Saptomycin D shows significant antitumor properties that make it a candidate for research in cancer therapy.

Parvodicin C2, a glycopeptide antibiotic derived from A. parvosata and part of the parvodicin complex, serves as a component of the A40926 antibiotic complex utilized as a precursor for synthesizing dalbavancin. It exhibits activity against methicillin-sensitive and methicillin-resistant strains of S. aureus, S. epidermidis, S. saprophyticus, S. hemolyticus, and E. faecalis.

Retro-indolicidin, a synthetic analog of the cathelicidin-derived antimicrobial peptide-amide indolicidin, comprises a reversed 13-amino acid sequence isolated

Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.