Antibatterico

Δ2-transEicosenoic acid, an α,β-unsaturated fatty acid, emerges as a by-product during the synthesis of Δ2-ciseicosenoic acid, which along with its salts, shows promise in diabetes treatment and lipid metabolism enhancement. Additionally, the compound 2-octadecenoic acid is recognized for its ability to enhance liver function and reduce blood sugar levels in streptozocin-induced diabetic rats.

MsbA-IN-6: potent antibiotic, hinders MsbA in gram-negative bacteria, kills E. coli, effective on drug-resistant strains.

CPFX2090, a cephalosporin antibacterial compound.

β-L-Gulopyranosyl-caldarchaetidyl-glycerol is the principal polar lipid in the archaeon T. acidophilum. Its cellular levels in T. acidophilum HO-62 show a positive correlation with culture pH and a negative correlation with temperature. This compound also serves as a standard for polar lipid quantification from T. acidophilum HO-62. [Matreya, LLC. Catalog No. 1303]

Tuberculosis Inhibitor 12, an oxadiazole derivative, effectively inhibits Mycobacterium tuberculosis, demonstrating inhibition rates of 82% and 78% at a

TMV-IN-3 is a chalcone derivative that inhibits TMV with a 120.3 μg/mL EC50, used in research on infection and cancer.

Elastase LasB-IN-1 (Compound 4b), a potent and selective inhibitor of elastase LasB, exhibits antibacterial activity and has been determined to possess an IC50

TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.

Acorafloxacin: broad-spectrum fluoroquinolone antibacterial for acute skin infections and pneumonia.

A 33853 is an antibiotic isolated from culture broth of Streptomyces sp.

DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram

Lithium benzoate, an aromatic alcohol present in numerous plants, commonly serves as an additive in food, beverages, cosmetics, and various other products. This compound exhibits antibacterial and antifungal properties, functioning effectively as a preservative [1].

LY 173013 is a bicyclic pyrazolidinone, it has antibacterial properties.

Antibacterial 91: Inhibits aaRS, IC50 2.10μM vs. S. enterica ThrRS, has antibacterial properties. [1]

Sterculic acid methyl ester, an ester derivative of sterculic acid known for inhibiting Δ9 desaturase, has been found to adversely affect and exhibit toxicity towards R. opacus bacteria at a concentration of 0.75 mM. It not only hampers bacterial growth but also modifies fatty acid composition by reducing stearate and oleate levels, increasing the palmitate ratio, and decreasing overall fatty acid content at 0.25 or 0.5 mM concentrations. Additionally, at 50 ppm, Sterculic acid methyl ester enhances the tumor growth-promoting effects of aflatoxin Q1 in rainbow trout, indicating a synergistic interaction between the two compounds. [Matreya, LLC. Catalog No. 1236]

SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM.

ThrRS-IN-3: Potent inhibitor of Salmonella enterica ThrRS, IC50 = 19 nM, Kd = 34 nM, with antibacterial effects.

LS-BF1: Stable, low-toxic antimicrobial peptide targeting ESKAPE pathogens via cell membrane disruption, effective in mouse infection model.

Sulfachloropyridazine (sodium) is a sulfonamide antibiotic that impedes bacterial proliferation [1].

L 680833 is an orally active monocyclic beta-lactam human polymorphonuclear leukocyte elastase inhibitor.