AMPK
Gli inibitori di AMPK sono composti che inibiscono la Proteina Chinasi Attivata da AMP (AMPK), un enzima che svolge un ruolo critico nell'omeostasi energetica cellulare. AMPK si attiva in risposta a bassi livelli di energia nelle cellule e aiuta a regolare processi come l'assorbimento del glucosio, l'ossidazione degli acidi grassi e la biogenesi mitocondriale. Inibire AMPK è importante per studiare il suo ruolo nelle malattie metaboliche, nel cancro e nell'invecchiamento. Presso CymitQuimica, offriamo una gamma di inibitori di AMPK per supportare la tua ricerca in metabolismo, oncologia e malattie legate all'età.
Trovati 161 prodotti per "AMPK".
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Annaosanchun
CAS:Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Formula:C19H32O3Purezza:99.58%Colore e forma:SolidPeso molecolare:308.46ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Formula:C46H51F3N6O8S2Purezza:98.34%Colore e forma:SolidPeso molecolare:937.06Ref: TM-T8432
1mg50,00€5mg114,00€10mg177,00€1mL*10mM (DMSO)185,00€25mg321,00€50mg482,00€100mg677,00€200mg928,00€HTH-01-015
CAS:HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).Formula:C26H28N8OPurezza:98.38% - 99.70%Colore e forma:Yellow SolidPeso molecolare:468.55Ref: TM-T2374
1mg42,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg101,00€25mg200,00€50mg286,00€100mg385,00€Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formula:C6H16ClN5Purezza:97.83%Colore e forma:SolidPeso molecolare:193.68PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formula:C19H16ClNO3Purezza:95.17% - 98.21%Colore e forma:SolidPeso molecolare:341.79Ref: TM-T4427
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg200,00€50mg334,00€100mg537,00€200mg762,00€7-Methoxyisoflavone
CAS:7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).Formula:C16H12O3Purezza:99.93% - 99.94%Colore e forma:White SolidPeso molecolare:252.26Methyl cinnamate
CAS:Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.Formula:C10H10O2Purezza:99.88%Colore e forma:White SolidPeso molecolare:162.19Cimiracemoside C
CAS:Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.Formula:C35H56O9Purezza:99.95%Colore e forma:SolidPeso molecolare:620.81Karanjin
CAS:Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.Formula:C18H12O4Purezza:99.01%Colore e forma:SolidPeso molecolare:292.29Ref: TM-T2S0820
1mg46,00€1mL*10mM (DMSO)94,00€5mg96,00€10mg145,00€25mg259,00€50mg385,00€100mg557,00€200mg790,00€EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Formula:C24H18ClN3O3Purezza:99.20% - 99.36%Colore e forma:White SolidPeso molecolare:431.87Ref: TM-TQ0028
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)80,00€10mg105,00€25mg210,00€50mg356,00€100mg535,00€A-769662
CAS:A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Formula:C20H12N2O3SPurezza:97.52% - 99.58%Colore e forma:SolidPeso molecolare:360.39Ref: TM-T2468
2mg37,00€5mg54,00€1mL*10mM (DMSO)56,00€10mg74,00€25mg135,00€50mg244,00€100mg440,00€500mg964,00€RGX-202
CAS:RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.Formula:C4H9N3O2Purezza:99.67% - 99.8%Colore e forma:SolidPeso molecolare:131.13Chromium(III) acetate
CAS:Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.Formula:C2H3O2CrPurezza:99.9%Colore e forma:Green SolidPeso molecolare:76.37Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formula:C27H29NO11Purezza:99.31% - 99.73%Colore e forma:Red Crystalline Solid SolidPeso molecolare:543.52Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Formula:C23H30O7Colore e forma:SolidPeso molecolare:418.486AD1058
CAS:AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.Formula:C19H20N6O3SPurezza:98.24%Colore e forma:Yellow SolidPeso molecolare:412.47Ref: TM-T200105
1mg66,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg222,00€25mg447,00€50mg685,00€100mg888,00€TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formula:C21H32O6Purezza:99.21%Colore e forma:Yellow SolidPeso molecolare:380.48Ref: TM-T13173
1mg75,00€5mg164,00€1mL*10mM (DMSO)167,00€10mg260,00€25mg440,00€50mg620,00€100mg964,00€PF-739
CAS:PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Formula:C23H23ClN2O5Purezza:98%Colore e forma:SolidPeso molecolare:442.89ULK1-IN-2
CAS:ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.Formula:C19H16BrFN4O6Purezza:99.07% - 99.97%Colore e forma:SolidPeso molecolare:495.26JJO-1
CAS:JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Formula:C19H13N3Colore e forma:SolidPeso molecolare:283.33AMPK activator
CAS:AMPK activatorFormula:C22H21FO4Purezza:98%Colore e forma:SolidPeso molecolare:368.4XMD-17-51
CAS:XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Formula:C21H24N8OPurezza:99.04%Colore e forma:SolidPeso molecolare:404.47AMPK activator 6
CAS:AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.Formula:C25H28O5Colore e forma:SolidPeso molecolare:408.49AMPK activator 9
CAS:AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Formula:C31H28F4N4O4Colore e forma:SolidPeso molecolare:596.57AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Formula:C23H24BrNO2Purezza:99.57%Colore e forma:SolidPeso molecolare:426.35IND 1316
CAS:IND 1316 is an activator of AMP-activated protein kinase (AMPK).Formula:C22H17NO3Colore e forma:SolidPeso molecolare:343.38AMPK activator 8
CAS:AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Formula:C25H21ClN2O6Colore e forma:SolidPeso molecolare:480.9AMPK activator 11
CAS:AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-Formula:C25H20N4O2Purezza:98%Colore e forma:SolidPeso molecolare:408.45OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Formula:C25H24F3N3O6S2Colore e forma:SolidPeso molecolare:583.6AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Formula:C24H21ClN2O3Purezza:99.97% - 99.99%Colore e forma:SolidPeso molecolare:420.89Ref: TM-T62238
1mg86,00€5mg173,00€1mL*10mM (DMSO)203,00€10mg334,00€25mg563,00€50mg802,00€100mg1.099,00€500mg2.187,00€LRRK2/NUAK1/TYK2-IN-1
CAS:LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Formula:C20H11F3N6Colore e forma:SolidPeso molecolare:392.34GL-V9
CAS:GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Formula:C24H27NO5Colore e forma:SolidPeso molecolare:409.47HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Formula:C13H17ClF3N5OPurezza:99.84%Colore e forma:SolidPeso molecolare:351.76AMPK activator 1
CAS:AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Formula:C32H33F3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:578.62SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formula:C36H34BrClFN5OPPurezza:98%Colore e forma:SolidPeso molecolare:718.02ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Formula:C20H25N3O3Purezza:98%Colore e forma:SolidPeso molecolare:355.43YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Formula:C21H21FN2OPurezza:98%Colore e forma:SolidPeso molecolare:336.4AMDE-1
CAS:AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.Formula:C18H8ClF6N3Purezza:90%Colore e forma:SolidPeso molecolare:415.72DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Formula:C16H8ClF6N3OPurezza:99.63%Colore e forma:White SolidPeso molecolare:407.7AMPK-IN-3
CAS:AMPK-IN-3: potent, selective AMPK (α2/α1) & KDR inhibitor; IC50: 60.7/107/3820 nM; anticancer in K562 cells.Formula:C25H33N5O3Purezza:97.25%Colore e forma:SolidPeso molecolare:451.56YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formula:C29H20ClNO3Purezza:97.74%Colore e forma:SolidPeso molecolare:465.93Ref: TM-T13368
1mg34,00€5mg79,00€1mL*10mM (DMSO)82,00€10mg111,00€25mg188,00€50mg269,00€100mg371,00€200mg512,00€PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formula:C17H16ClN3O3Purezza:97.01%Colore e forma:SolidPeso molecolare:345.78Ref: TM-T24626
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg236,00€50mg344,00€100mg482,00€200mg662,00€AMPK-IN-1
CAS:AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formula:C24H18ClN3O3Colore e forma:SolidPeso molecolare:431.87MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formula:C22H24F2N6O2Purezza:99.47% - >99.99%Colore e forma:SolidPeso molecolare:442.46AMPK activator 7
CAS:AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Formula:C23H22F3N3O5Colore e forma:SolidPeso molecolare:477.43PF-06679142
CAS:PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formula:C20H17F2NO3Purezza:98%Colore e forma:SolidPeso molecolare:357.35MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formula:C18H18ClF2N5OSPurezza:98%Colore e forma:SolidPeso molecolare:425.88Butylate
CAS:Butylate is a herbicide of thiocarbamate.Formula:C11H23NOSColore e forma:SolidPeso molecolare:217.37MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formula:C22H23F2N7OSPurezza:98%Colore e forma:SolidPeso molecolare:471.53MRT199665
CAS:MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Formula:C28H31N5O2Colore e forma:SolidPeso molecolare:469.58
