AMPK
Gli inibitori di AMPK sono composti che inibiscono la Proteina Chinasi Attivata da AMP (AMPK), un enzima che svolge un ruolo critico nell'omeostasi energetica cellulare. AMPK si attiva in risposta a bassi livelli di energia nelle cellule e aiuta a regolare processi come l'assorbimento del glucosio, l'ossidazione degli acidi grassi e la biogenesi mitocondriale. Inibire AMPK è importante per studiare il suo ruolo nelle malattie metaboliche, nel cancro e nell'invecchiamento. Presso CymitQuimica, offriamo una gamma di inibitori di AMPK per supportare la tua ricerca in metabolismo, oncologia e malattie legate all'età.
Trovati 169 prodotti di "AMPK"
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Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Formula:C16H30O2Purezza:99.76%Colore e forma:SolidPeso molecolare:254.41YKL-06-061
CAS:YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.Formula:C30H37N7O2Purezza:99.52% - 99.79%Colore e forma:SolidPeso molecolare:527.66Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurezza:98.89% - 99.28%Colore e forma:SolidPeso molecolare:265.25Kudinoside D
CAS:Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.Formula:C47H72O17Purezza:99.66% - 99.92%Colore e forma:SolidPeso molecolare:909.06Annaosanchun
CAS:Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Formula:C19H32O3Purezza:99.58%Colore e forma:SolidPeso molecolare:308.46ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Formula:C46H51F3N6O8S2Purezza:98.34%Colore e forma:SolidPeso molecolare:937.06HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formula:C26H28N8OPurezza:98.38% - 99.70%Colore e forma:SolidPeso molecolare:468.55Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formula:C6H16ClN5Purezza:97.83%Colore e forma:SolidPeso molecolare:193.68PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formula:C19H16ClNO3Purezza:95.17% - 98.21%Colore e forma:SolidPeso molecolare:341.797-Methoxyisoflavone
CAS:7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).Formula:C16H12O3Purezza:99.93% - 99.94%Colore e forma:SolidPeso molecolare:252.26Methyl cinnamate
CAS:<p>Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.</p>Formula:C10H10O2Purezza:99.88%Colore e forma:Colorless To Pale Yellow Solid CrystallinePeso molecolare:162.19Cimiracemoside C
CAS:Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.Formula:C35H56O9Purezza:99.95%Colore e forma:SolidPeso molecolare:620.81Karanjin
CAS:Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.Formula:C18H12O4Purezza:99.01%Colore e forma:SolidPeso molecolare:292.298-Chloroadenosine
CAS:8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.Formula:C10H12ClN5O4Purezza:98.75% - 99.84%Colore e forma:SolidPeso molecolare:301.69EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Formula:C24H18ClN3O3Purezza:99.20% - 99.36%Colore e forma:SolidPeso molecolare:431.87A-769662
CAS:A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Formula:C20H12N2O3SPurezza:97.52% - 99.58%Colore e forma:SolidPeso molecolare:360.39RGX-202
CAS:RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.Formula:C4H9N3O2Purezza:99.67% - 99.8%Colore e forma:SolidPeso molecolare:131.13Chromium(III) acetate
CAS:Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.Formula:C2H3O2CrPurezza:99.9%Colore e forma:Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InPeso molecolare:76.37Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formula:C27H29NO11Purezza:99.31%Colore e forma:Red Crystalline Solid SolidPeso molecolare:543.52AD1058
CAS:AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.Formula:C19H20N6O3SPurezza:98.24%Colore e forma:SolidPeso molecolare:412.47Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Formula:C23H30O7Colore e forma:SolidPeso molecolare:418.486TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formula:C21H32O6Purezza:99.21%Colore e forma:SolidPeso molecolare:380.48AMPK activator 9
CAS:AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Formula:C31H28F4N4O4Colore e forma:SolidPeso molecolare:596.57ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Formula:C20H25N3O3Purezza:98%Colore e forma:SolidPeso molecolare:355.43ULK1-IN-2
CAS:ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.Formula:C19H16BrFN4O6Purezza:99.07% - 99.97%Colore e forma:SolidPeso molecolare:495.26JJO-1
CAS:JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Formula:C19H13N3Colore e forma:SolidPeso molecolare:283.33AMPK activator
CAS:AMPK activatorFormula:C22H21FO4Purezza:98%Colore e forma:SolidPeso molecolare:368.4AMPK activator 8
CAS:AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Formula:C25H21ClN2O6Colore e forma:SolidPeso molecolare:480.9SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formula:C36H34BrClFN5OPPurezza:98%Colore e forma:SolidPeso molecolare:718.02IND 1316
CAS:IND 1316 is an activator of AMP-activated protein kinase (AMPK).Formula:C22H17NO3Colore e forma:SolidPeso molecolare:343.38AMDE-1
CAS:<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Formula:C18H8ClF6N3Purezza:90%Colore e forma:SolidPeso molecolare:415.72OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Formula:C25H24F3N3O6S2Colore e forma:SolidPeso molecolare:583.6AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Formula:C24H21ClN2O3Purezza:99.97% - 99.99%Colore e forma:SolidPeso molecolare:420.89AMPK activator 1
CAS:AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Formula:C32H33F3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:578.62GL-V9
CAS:GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Formula:C24H27NO5Colore e forma:SolidPeso molecolare:409.47Galegine hydrochloride
CAS:Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Formula:C6H14ClN3Colore e forma:SolidPeso molecolare:163.65HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Formula:C13H17ClF3N5OPurezza:98%Colore e forma:SolidPeso molecolare:351.76LRRK2/NUAK1/TYK2-IN-1
CAS:LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Formula:C20H11F3N6Colore e forma:SolidPeso molecolare:392.34MARK-IN-4
CAS:MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.Formula:C21H23N7OSColore e forma:SolidPeso molecolare:421.52AMPK activator 11
CAS:AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-Formula:C25H20N4O2Purezza:98%Colore e forma:SolidPeso molecolare:408.45AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Formula:C23H24BrNO2Purezza:99.55%Colore e forma:SolidPeso molecolare:426.35AMPK activator 6
CAS:AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.Formula:C25H28O5Colore e forma:SolidPeso molecolare:408.49XMD-17-51
CAS:XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Formula:C21H24N8OPurezza:99.04%Colore e forma:SoildPeso molecolare:404.47PF-739
CAS:PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Formula:C23H23ClN2O5Purezza:98%Colore e forma:SolidPeso molecolare:442.89YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Formula:C21H21FN2OPurezza:98%Colore e forma:SolidPeso molecolare:336.4DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Formula:C16H8ClF6N3OPurezza:99.63%Colore e forma:SolidPeso molecolare:407.7YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formula:C29H20ClNO3Purezza:97.74%Colore e forma:SolidPeso molecolare:465.93PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formula:C17H16ClN3O3Purezza:97.01%Colore e forma:SolidPeso molecolare:345.78MRT199665
CAS:MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Formula:C28H31N5O2Colore e forma:SolidPeso molecolare:469.58ZLN024
CAS:<p>ZLN024 is an activator of AMPK allosteric.</p>Formula:C13H13BrN2OSPurezza:99.751%Colore e forma:SolidPeso molecolare:325.22
