PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 235 prodotti di "PI3K"
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ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Formula:C20H27N9O3SPurezza:99.8%Colore e forma:SolidPeso molecolare:473.55Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFormula:C14H11ClN6O3Purezza:99.25% - 99.41%Colore e forma:SolidPeso molecolare:346.73Taselisib
CAS:Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.Formula:C24H28N8O2Purezza:99.62% - 99.79%Colore e forma:SolidPeso molecolare:460.53IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurezza:99.31%Colore e forma:SolidPeso molecolare:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purezza:98.92%Colore e forma:SolidPeso molecolare:338.35Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:450.46Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purezza:96.66% - 99.93%Colore e forma:SolidPeso molecolare:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purezza:95.74% - 99.78%Colore e forma:SolidPeso molecolare:534.53NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurezza:99.84% - 99.9%Colore e forma:SolidPeso molecolare:385.41GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.44Alpelisib hydrochloride
CAS:Alpelisib hydrochloride (BYL-719 HCl) is a potent PI3Kα inhibitor (IC₅₀ = 5 nM) with selectivity and oral bioavailability. Cancer research.Formula:C19H23ClF3N5O2SPurezza:97.64%Colore e forma:SolidPeso molecolare:477.93Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formula:C23H26N4O3Purezza:98.41% - 99.69%Colore e forma:SolidPeso molecolare:406.48Heterophyllin B
CAS:<p>Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.</p>Formula:C40H58N8O8Purezza:99.12% - 99.85%Colore e forma:SolidPeso molecolare:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Formula:C21H16FN7Purezza:98.9% - 99.24%Colore e forma:Crystalline SolidPeso molecolare:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Formula:C22H19Br2FN2OPurezza:96.83% - ≥98%Colore e forma:SolidPeso molecolare:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurezza:98.21% - 99.69%Colore e forma:SolidPeso molecolare:270.29Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Formula:C31H24F3N5O3Purezza:99.56% - 99.56%Colore e forma:White SolidPeso molecolare:571.55AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Formula:C22H31N9O3Purezza:98.22% - 99.88%Colore e forma:SolidPeso molecolare:469.54AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Formula:C11H5F2NO4SPurezza:99.65%Colore e forma:SolidPeso molecolare:285.22PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purezza:97.72%Colore e forma:SolidPeso molecolare:389.88CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Formula:C15H19N7O3SPurezza:99.41% - 99.87%Colore e forma:SolidPeso molecolare:377.42Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Formula:C23H14ClF3N6OPurezza:99.81%Colore e forma:SolidPeso molecolare:482.85α-Linolenic acid
CAS:α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.Formula:C18H30O2Purezza:97.05% - 99.81%Colore e forma:Physical Description Clear Colorless Liquid (Ntp 1992)Peso molecolare:278.43GSK2636771
CAS:<p>GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and</p>Formula:C22H22F3N3O3Purezza:98.58% - ≥95%Colore e forma:SolidPeso molecolare:433.42Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Formula:C21H24ClN7OPurezza:97.04%Colore e forma:SolidPeso molecolare:425.91SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Formula:C19H21ClF3N5O2Purezza:99.42% - 99.79%Colore e forma:SolidPeso molecolare:443.85PIK-90
CAS:<p>PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .</p>Formula:C18H17N5O3Purezza:98.25% - ≥95%Colore e forma:SolidPeso molecolare:351.36A66
CAS:A66 is a specific and effective p110α inhibitor(IC50=32 nM).Formula:C17H23N5O2S2Purezza:99.51% - ≥95%Colore e forma:SolidPeso molecolare:393.53Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFormula:C28H37FN6O5SPurezza:99.01%Colore e forma:SolidPeso molecolare:588.69Vps34-IN-4
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Formula:C21H25N7OPurezza:98.6%Colore e forma:SolidPeso molecolare:391.47CAY10505
CAS:CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).Formula:C14H8FNO3SPurezza:99.69% - 99.74%Colore e forma:SolidPeso molecolare:289.28GDC-0326
CAS:GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).Formula:C19H22N6O3Purezza:99.35% - >99.99%Colore e forma:SolidPeso molecolare:382.42AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Formula:C24H25F2N3O4Purezza:99.89% - 99.91%Colore e forma:SolidPeso molecolare:457.47Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Formula:C23H20FN7OPurezza:97.96%Colore e forma:SolidPeso molecolare:429.45Pilaralisib analogue
CAS:Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.Formula:C21H16N6O2S2Purezza:99.3% - 99.72%Colore e forma:SolidPeso molecolare:448.52AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Formula:C22H24N4O4Purezza:99.87% - 99.95%Colore e forma:SolidPeso molecolare:408.45PIK-293
CAS:PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.Formula:C22H19N7OPurezza:99.88%Colore e forma:SolidPeso molecolare:397.43ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Formula:C16H17N5O2Purezza:99.14%Colore e forma:SolidPeso molecolare:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurezza:97.64% - 99.85%Colore e forma:SolidPeso molecolare:469.54Pectolinarin
CAS:Pectolinarin is a Cirsium isolate with anti-inflammatory activity.Formula:C29H34O15Purezza:98% - 99.79%Colore e forma:SolidPeso molecolare:622.57GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurezza:98.42% - 99.54%Colore e forma:SolidPeso molecolare:414.48Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Formula:C23H27N7O3S2Purezza:98.69% - 99.97%Colore e forma:SolidPeso molecolare:513.64Sincalide
CAS:Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.Formula:C49H62N10O16S3Purezza:98.32%Colore e forma:SolidPeso molecolare:1143.27IC-87114
CAS:<p>IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).</p>Formula:C22H19N7OPurezza:99.30% - >99.99%Colore e forma:SolidPeso molecolare:397.43Orobol
CAS:Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.Formula:C15H10O6Purezza:98% - 98%Colore e forma:SolidPeso molecolare:286.24Musk ketone
CAS:<p>Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.</p>Formula:C14H18N2O5Purezza:99.85%Colore e forma:Yellow Crystals Physical Description Light Yellow Crystalline Solid Insoluble In Water (Ntp 1992)Peso molecolare:294.30AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Formula:C11H7NO4SPurezza:99.45%Colore e forma:SolidPeso molecolare:249.24PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Formula:C18H23F2N7O2Purezza:99.5%Colore e forma:SolidPeso molecolare:407.42YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Formula:C25H21N7O3Purezza:93.28% - 98.3%Colore e forma:SolidPeso molecolare:467.48Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Formula:C53H86O23Purezza:98% - 99.83%Colore e forma:SolidPeso molecolare:1091.24
