ATM/ATR
Gli inibitori di ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) prendono di mira chinasi chiave coinvolte nella risposta al danno al DNA (DDR) che vengono attivate in risposta a rotture del doppio filamento di DNA e stress da replicazione. Questi inibitori interrompono la capacità di queste chinasi di rilevare e riparare i danni al DNA, il che può portare a un aumento dell'instabilità genomica e alla morte cellulare, in particolare nelle cellule tumorali che dipendono da robusti meccanismi di riparazione del DNA per sopravvivere. Gli inibitori di ATM/ATR sono strumenti cruciali nella ricerca e nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una vasta gamma di inibitori di ATM/ATR di alta qualità per supportare la tua ricerca sulla risposta al danno al DNA, la biologia del cancro e lo sviluppo terapeutico.
Trovati 72 prodotti di "ATM/ATR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purezza:99.13% - 99.92%Colore e forma:SolidPeso molecolare:414.45Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFormula:C20H22ClN7OPurezza:98.8% - 99.03%Colore e forma:SolidPeso molecolare:411.89FEN1-IN-1
CAS:FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.Formula:C15H12N2O5SPurezza:99.65% - 99.80%Colore e forma:SolidPeso molecolare:332.33Antitumor agent-28
CAS:Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Formula:C25H32N6O4SColore e forma:SolidPeso molecolare:512.63GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Formula:C20H29N3O7SPurezza:99.97%Colore e forma:SolidPeso molecolare:455.53Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formula:C36H48N6O7Purezza:98%Colore e forma:SolidPeso molecolare:676.8Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C24H25N5O3SPurezza:97.34% - >99.99%Colore e forma:SolidPeso molecolare:463.55ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Formula:C25H32N6O2Purezza:98%Colore e forma:SolidPeso molecolare:448.56CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Formula:C34H46N2O6SColore e forma:SolidPeso molecolare:610.80ATR-IN-9
CAS:ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Formula:C22H27N7O2Colore e forma:SolidPeso molecolare:421.505ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFormula:C26H34N6O2Purezza:98%Colore e forma:SolidPeso molecolare:462.59Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Formula:C41H42N8O7SColore e forma:SolidPeso molecolare:790.89VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Formula:C18H16N4O3SPurezza:97.19% - 99.97%Colore e forma:SolidPeso molecolare:368.41Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formula:C20H24N6O2SPurezza:98% - 99.99%Colore e forma:SolidPeso molecolare:412.51GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formula:C16H13N4NaO3SPurezza:99.70% - 99.91%Colore e forma:SolidPeso molecolare:364.36AZD0156
CAS:<p>AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.</p>Formula:C26H31N5O3Purezza:99.13% - 99.87%Colore e forma:SolidPeso molecolare:461.56CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Formula:C17H15N7O2Purezza:99.1% - 99.14%Colore e forma:SolidPeso molecolare:349.35KU-55933
CAS:<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Formula:C21H17NO3S2Purezza:97.21% - >99.99%Colore e forma:SolidPeso molecolare:395.49AZ20
CAS:<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Formula:C21H24N4O3SPurezza:98% - 99.69%Colore e forma:SolidPeso molecolare:412.51NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purezza:98.36%Colore e forma:SolidPeso molecolare:251.29ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purezza:97.76%Colore e forma:SolidPeso molecolare:470.52azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Formula:C27H32FN5O2Purezza:97.41% - 99.72%Colore e forma:SolidPeso molecolare:477.57Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurezza:97.64% - 99.85%Colore e forma:SolidPeso molecolare:469.54Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormula:C20H21N7OPurezza:98.72% - 99.84%Colore e forma:SolidPeso molecolare:375.43PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purezza:97.72%Colore e forma:SolidPeso molecolare:389.88AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purezza:99.03% - 99.85%Colore e forma:SolidPeso molecolare:380.4CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Formula:C23H18Cl3FN4O3SPurezza:98% - 99.67%Colore e forma:SolidPeso molecolare:555.84Adefovir dipivoxil
CAS:Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFormula:C20H32N5O8PPurezza:98% - 99.80%Colore e forma:It Has Broad-Spectrum Antiviral ActivityPeso molecolare:501.47KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Formula:C30H33N3O5SPurezza:95.9% - 99.7%Colore e forma:SolidPeso molecolare:547.67AZ32
CAS:AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.Formula:C20H16N4OPurezza:98.68% - 99.68%Colore e forma:SolidPeso molecolare:328.37Mirin
CAS:Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.Formula:C10H8N2O2SPurezza:99.24%Colore e forma:SolidPeso molecolare:220.25ART0380
CAS:<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>Formula:C18H24N6O2SPurezza:99.06% - >99.99%Colore e forma:SolidPeso molecolare:388.49ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Formula:C27H24N4OColore e forma:SolidPeso molecolare:420.51Ceralasertib formate
CAS:Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.Formula:C21H26N6O4SColore e forma:SolidPeso molecolare:458.54ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Formula:C19H25N7OColore e forma:SolidPeso molecolare:367.45ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Formula:C19H22N8OColore e forma:SolidPeso molecolare:378.43Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Formula:C25H29F2N9O3Purezza:99.52%Colore e forma:SolidPeso molecolare:541.55ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purezza:98%Colore e forma:SolidPeso molecolare:458.56SKLB-197
CAS:SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.Formula:C25H24N6OColore e forma:SolidPeso molecolare:424.5(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Formula:C20H24N6O2SColore e forma:SolidPeso molecolare:412.51ATR-IN-6
CAS:ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.Formula:C28H28FN7O2Colore e forma:SolidPeso molecolare:513.57ATR-IN-18
CAS:ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.Formula:C19H22F3N7O5SColore e forma:SolidPeso molecolare:517.48ATR-IN-5
CAS:ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Formula:C27H32F3N9OColore e forma:SolidPeso molecolare:555.6ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Formula:C29H31N5O4SColore e forma:SolidPeso molecolare:545.65ATR-IN-8
CAS:ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.Formula:C20H22N6O2SColore e forma:SolidPeso molecolare:410.49ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Formula:C19H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:378.43ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Formula:C23H27N7OPurezza:98%Colore e forma:SolidPeso molecolare:417.51ATR-IN-13
CAS:ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Formula:C24H24FN9OColore e forma:SolidPeso molecolare:473.51AZ 5704
CAS:ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.Formula:C23H23FN6O2Colore e forma:SolidPeso molecolare:434.47ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Formula:C30H36N6O3Colore e forma:SolidPeso molecolare:528.65
