mTOR

Everolimus is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or …

Apitolisib, an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ …

mTOR inhibitor-3 is an inhibitor of remarkably selective mTOR (Ki : 1.5 nM)

Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also …

N6-Cyclopentyladenosine (CPA) is a selective agonist of Adenosine A1 receptor (Ki: 2.3 nM, 790 nM …

Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl …

Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR …

SF2523 is a highly selective and potent inhibitor.

Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of …

Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). …

Tacrolimus can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the …

GSK2126458 is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.

NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).

LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).

Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with …

Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor …

AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a …

MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between …

Zotarolimus, an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).

NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.

JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme …

GDC-0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC-0084 specifically inhibits PI3K in …

GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, …

FT-1518 ,exhibits antitumor activity, is a new generation selective, potent and oral bioavailable mTORC1 and …

PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.

CZ415 is a potent and highly selective mTOR inhibitor.

BIA is a bax inhibitor

DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor …

C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.

K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion …

mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).

Temsirolimus is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of …

Leucine is one of nine essential amino acids in humans (provided by food), Leucine is …

Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 …

3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; …

MLN1117 (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).

CH5132799 has been used in trials studying the treatment of Solid Tumors.

Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity …

Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold …

Gedatolisib is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: …

XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold …

Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and …

Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.

LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.

1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer activity. (+)-9,9'-O-Diferuloylsecoisolariciresinol has …

Bgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with …

WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), …

KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.

LY303511 (NV-128)is a potent mTOR inhibitor

ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, …

PI-3065 is a novel potent and selective PI3K p110δ inhibitor.

OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of …

BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT …

WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly …

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks …

VS-5584 is a pan-PI3K/mTOR kinase inhibitor.

AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold …

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.

INK 128 is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and …

CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).

LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and …