mTOR
Gli inibitori di mTOR sono composti che inibiscono l'attività del Bersaglio della Rapamicina nei Mammiferi (mTOR), un regolatore centrale della crescita cellulare, della proliferazione, del metabolismo e della sopravvivenza. La via di mTOR è frequentemente alterata nel cancro e in altre malattie, rendendo mTOR un bersaglio critico per l'intervento terapeutico. Gli inibitori di mTOR sono ampiamente utilizzati nella ricerca sul cancro, l'invecchiamento e i disturbi metabolici. Presso CymitQuimica, offriamo una varietà di inibitori di mTOR per supportare la tua ricerca nella trasduzione del segnale, oncologia e sviluppo terapeutico.
Trovati 162 prodotti di "mTOR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ICSN3250 HCl
CAS:<p>ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, preventing mTOR activation and leading to cytotoxicity.</p>Formula:C31H41ClN4O8Purezza:98.46% - 99.60%Colore e forma:SoildPeso molecolare:633.13Rapamycin
CAS:<p>Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.</p>Formula:C51H79NO13Purezza:97.08% - 99.80%Colore e forma:Yellow SolidPeso molecolare:914.17MT 63-78
CAS:<p>MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).</p>Formula:C21H14N2O2Purezza:97.11%Colore e forma:SolidPeso molecolare:326.35NSC781406
CAS:<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formula:C29H27F2N5O5S2Purezza:99.58%Colore e forma:SolidPeso molecolare:627.68Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formula:C21H27ClN2S2Purezza:99.55% - 99.957%Colore e forma:White To Off-White SolidPeso molecolare:407.04SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Formula:C24H33F2N9O4SPurezza:98.06%Colore e forma:SolidPeso molecolare:581.64NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Formula:C7H13F2NO2Purezza:98% - ≥98%Colore e forma:SolidPeso molecolare:181.18RMC-4627
CAS:RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.Formula:C93H141N11O23Colore e forma:SolidPeso molecolare:1781.17MCX 28
CAS:MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.Formula:C25H19N5O4S3Colore e forma:SolidPeso molecolare:549.64Aschantin
CAS:<p>Aschantin is a useful organic compound for research related to life sciences. The catalog number is T126072 and the CAS number is 13060-15-6.</p>Formula:C22H24O7Colore e forma:SolidPeso molecolare:400.427PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Colore e forma:Odour SolidYB-3-17
CAS:YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)Formula:C38H39N11O6Colore e forma:SolidPeso molecolare:745.786MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Formula:C22H16N4O4Purezza:99.63% - 99.85%Colore e forma:SolidPeso molecolare:400.39FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:Liquid(32-Carbonyl)-RMC-5552
CAS:(32-Carbonyl)-RMC-5552, a potent mTOR inhibitor, blocks mTORC1/C2, with pIC50 values >9 for p-P70S6K and p-4E-BP1, and 8~9 for p-AKT1/2/3.Formula:C93H134N10O24Colore e forma:SolidPeso molecolare:1776.1412DII
2DII is a potent and selective mTORC2 inhibitor. It specifically binds to the mSin1 PH domain, resulting in a decreased phosphorylation of AKT1.Formula:C54H76ClN7O11SColore e forma:SolidPeso molecolare:1066.74mTOR inhibitor 9f
CAS:mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.Formula:C25H23N5O2SPurezza:99.18%Colore e forma:SoildPeso molecolare:457.55PF-06465603
CAS:PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.Formula:C22H25N5O5Colore e forma:SolidPeso molecolare:439.46mTOR inhibitor 13
CAS:Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).Formula:C24H22N6O2SPurezza:99.75%Colore e forma:SolidPeso molecolare:458.54DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Colore e forma:Odour SolidThioether-cyclized helix B peptide, CHBP TFA
Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP.Formula:C56H93N19O22S·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:1416.52 (free base)WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formula:C28H32N8O3Purezza:99.93%Colore e forma:SolidPeso molecolare:528.61mTOR inhibitor-14
<p>mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1</p>Purezza:98%Colore e forma:Odour SolidmTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFormula:C19H24N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:400.5mTOR inhibitor WYE-28
CAS:Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).Formula:C30H34N8O5Colore e forma:SolidPeso molecolare:586.653PI3K-IN-22
CAS:<p>PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.</p>Formula:C31H35F3N8O3Colore e forma:SolidPeso molecolare:624.66RMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Formula:C90H139N13O23Colore e forma:SolidPeso molecolare:1771.17Thioether-cyclized helix B peptide, CHBP
CAS:Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTORFormula:C56H93N19O22SPurezza:98%Colore e forma:SolidPeso molecolare:1416.52Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidRMC-6272
CAS:RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.Formula:C95H141FN6O27SColore e forma:SolidPeso molecolare:1850.25DEPTOR-IN-1
CAS:DEPTOR-IN-1 is an inhibitor of DEPTOR with a Kd of 9.3 μM.Formula:C24H16Cl2FNO4Purezza:97.84%Colore e forma:SolidPeso molecolare:472.29AJ2-30
CAS:AJ2-30: Inhibits SLCl5A4, TLR9-B cell activation, MDP transport, NOD signaling; for inflammation study.Formula:C23H22N4Purezza:>99.99%Colore e forma:SoildPeso molecolare:354.45QL-IX-55
CAS:QL-IX-55 has a wide range of applications in life science related research.Formula:C24H14F4N4OColore e forma:SolidPeso molecolare:450.39Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Formula:C35H58N6O9Purezza:98.59%Colore e forma:SolidPeso molecolare:706.87RMC-5552
CAS:RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.Formula:C93H136N10O24Colore e forma:SolidPeso molecolare:1778.16Anti-Phospho-MTOR (Ser2448) Antibody (2K503)
<p>Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.</p>Colore e forma:Odour LiquidAnti-Phospho-mTOR (Ser2481) Antibody (4R8)
Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.Colore e forma:Odour LiquidS6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Formula:C16H17BrN6OPurezza:99.99%Colore e forma:SolidPeso molecolare:389.25Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purezza:98.92%Colore e forma:SolidPeso molecolare:338.35Omipalisib
CAS:<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formula:C25H17F2N5O3SPurezza:98% - 99.8%Colore e forma:SolidPeso molecolare:505.5mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Formula:C16H15BrN2O3Purezza:99.43%Colore e forma:SolidPeso molecolare:363.21Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Formula:C43H45BrCl2N3OPPurezza:97.25% - 98.34%Colore e forma:SolidPeso molecolare:801.62Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formula:C23H26N4O3Purezza:98.41% - 99.69%Colore e forma:SolidPeso molecolare:406.48WYE-687 dihydrochloride
CAS:WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).Formula:C28H34Cl2N8O3Colore e forma:SolidPeso molecolare:601.53Corynoxine
CAS:<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formula:C22H28N2O4Purezza:96.83% - 99.93%Colore e forma:SolidPeso molecolare:384.47Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Formula:C14H20O7Purezza:97.81%Colore e forma:Red-Brown Fine PowderPeso molecolare:300.30PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formula:C22H27N5O4Purezza:96.27% - ≥95%Colore e forma:SolidPeso molecolare:425.48GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formula:C21H28N8O3S2Purezza:98.88% - 99.55%Colore e forma:SolidPeso molecolare:504.63OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formula:C21H22N6O3Purezza:97.42%Colore e forma:SolidPeso molecolare:406.44
