mTOR
Gli inibitori di mTOR sono composti che inibiscono l'attività del Bersaglio della Rapamicina nei Mammiferi (mTOR), un regolatore centrale della crescita cellulare, della proliferazione, del metabolismo e della sopravvivenza. La via di mTOR è frequentemente alterata nel cancro e in altre malattie, rendendo mTOR un bersaglio critico per l'intervento terapeutico. Gli inibitori di mTOR sono ampiamente utilizzati nella ricerca sul cancro, l'invecchiamento e i disturbi metabolici. Presso CymitQuimica, offriamo una varietà di inibitori di mTOR per supportare la tua ricerca nella trasduzione del segnale, oncologia e sviluppo terapeutico.
Trovati 160 prodotti di "mTOR"
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PI3K/mTOR Inhibitor-14
CAS:PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, andFormula:C28H30N8O3SPurezza:98%Colore e forma:SolidPeso molecolare:558.66mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFormula:C21H23N5O2SPurezza:99.89%Colore e forma:SoildPeso molecolare:409.5MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formula:C26H30N6O3Purezza:99.97%Colore e forma:SolidPeso molecolare:474.55PI3K/mTOR Inhibitor-6
CAS:Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.Formula:C30H34N10O4Colore e forma:SolidPeso molecolare:598.66PI3K/mTOR Inhibitor-7
CAS:Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.Formula:C29H33N9O4Colore e forma:SolidPeso molecolare:571.63WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Formula:C27H33N7O4Purezza:99.16%Colore e forma:SolidPeso molecolare:519.6PI3K/mTOR Inhibitor-5
CAS:PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.Formula:C32H40N10O3Colore e forma:SolidPeso molecolare:612.73mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Formula:C21H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:394.47PI3K/mTOR Inhibitor-1
CAS:PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)Formula:C18H22FN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:407.46mTOR inhibitor 9d
CAS:mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,Formula:C21H23N5O3SPurezza:98.91%Colore e forma:SoildPeso molecolare:425.5GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formula:C18H22N6O2SPurezza:99.77%Colore e forma:SolidPeso molecolare:386.47Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Formula:C25H19BrCl2N2O3SPurezza:99.72%Colore e forma:SolidPeso molecolare:578.3WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Formula:C28H30N8OPurezza:99.88%Colore e forma:SolidPeso molecolare:494.59PF-04979064
CAS:<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Formula:C24H26N6O3Purezza:98.20% - ≥98%Colore e forma:SolidPeso molecolare:446.5PKI-402
CAS:PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.Formula:C29H34N10O3Purezza:99.94%Colore e forma:SolidPeso molecolare:570.65GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formula:C24H32N6O3Purezza:96.00% - 98.17%Colore e forma:SolidPeso molecolare:452.55PD-M6
CAS:PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.Formula:C30H39N9O6Colore e forma:SolidPeso molecolare:621.69PI3K-IN-37
CAS:PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.51AZD 3147
CAS:<p>AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).</p>Formula:C24H31N5O4S2Purezza:99.99%Colore e forma:SolidPeso molecolare:517.66mTORC1-IN-1
<p>mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases</p>Purezza:98%Colore e forma:Odour Solid
