mTOR
Gli inibitori di mTOR sono composti che inibiscono l'attività del Bersaglio della Rapamicina nei Mammiferi (mTOR), un regolatore centrale della crescita cellulare, della proliferazione, del metabolismo e della sopravvivenza. La via di mTOR è frequentemente alterata nel cancro e in altre malattie, rendendo mTOR un bersaglio critico per l'intervento terapeutico. Gli inibitori di mTOR sono ampiamente utilizzati nella ricerca sul cancro, l'invecchiamento e i disturbi metabolici. Presso CymitQuimica, offriamo una varietà di inibitori di mTOR per supportare la tua ricerca nella trasduzione del segnale, oncologia e sviluppo terapeutico.
Trovati 161 prodotti di "mTOR"
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SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Formula:C24H33F2N9O4SPurezza:98.06%Colore e forma:SolidPeso molecolare:581.64Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formula:C21H27ClN2S2Purezza:99.55% - 99.957%Colore e forma:White To Off-White SolidPeso molecolare:407.04MT 63-78
CAS:<p>MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).</p>Formula:C21H14N2O2Purezza:97.11%Colore e forma:SolidPeso molecolare:326.35NSC781406
CAS:<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formula:C29H27F2N5O5S2Purezza:99.58%Colore e forma:SolidPeso molecolare:627.68NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Formula:C7H13F2NO2Purezza:98% - ≥98%Colore e forma:SolidPeso molecolare:181.18Rapamycin
CAS:<p>Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.</p>Formula:C51H79NO13Purezza:97.08% - 99.80%Colore e forma:Yellow SolidPeso molecolare:914.17ICSN3250 HCl
CAS:<p>ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, preventing mTOR activation and leading to cytotoxicity.</p>Formula:C31H41ClN4O8Purezza:98.46% - 99.60%Colore e forma:SoildPeso molecolare:633.13RMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Formula:C90H139N13O23Colore e forma:SolidPeso molecolare:1771.17mTOR inhibitor WYE-28
CAS:Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).Formula:C30H34N8O5Colore e forma:SolidPeso molecolare:586.653mTOR inhibitor-14
<p>mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1</p>Purezza:98%Colore e forma:Odour SolidPF-06465603
CAS:PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.Formula:C22H25N5O5Colore e forma:SolidPeso molecolare:439.46DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Colore e forma:Odour SolidRMC-6272
CAS:RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.Formula:C95H141FN6O27SColore e forma:SolidPeso molecolare:1850.25FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidDEPTOR-IN-1
CAS:DEPTOR-IN-1 is an inhibitor of DEPTOR with a Kd of 9.3 μM.Formula:C24H16Cl2FNO4Purezza:97.84%Colore e forma:SolidPeso molecolare:472.29mTOR inhibitor 13
CAS:Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).Formula:C24H22N6O2SPurezza:99.75%Colore e forma:SolidPeso molecolare:458.54mTOR inhibitor 9f
CAS:mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.Formula:C25H23N5O2SPurezza:99.18%Colore e forma:SoildPeso molecolare:457.55Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Colore e forma:Odour Solid(32-Carbonyl)-RMC-5552
CAS:(32-Carbonyl)-RMC-5552, a potent mTOR inhibitor, blocks mTORC1/C2, with pIC50 values >9 for p-P70S6K and p-4E-BP1, and 8~9 for p-AKT1/2/3.Formula:C93H134N10O24Colore e forma:SolidPeso molecolare:1776.1412DII
2DII is a potent and selective mTORC2 inhibitor. It specifically binds to the mSin1 PH domain, resulting in a decreased phosphorylation of AKT1.Formula:C54H76ClN7O11SColore e forma:SolidPeso molecolare:1066.74AJ2-30
CAS:AJ2-30: Inhibits SLCl5A4, TLR9-B cell activation, MDP transport, NOD signaling; for inflammation study.Formula:C23H22N4Purezza:>99.99%Colore e forma:SoildPeso molecolare:354.45MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Formula:C22H16N4O4Purezza:99.63% - 99.85%Colore e forma:SolidPeso molecolare:400.39RMC-4627
CAS:RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.Formula:C93H141N11O23Colore e forma:SolidPeso molecolare:1781.17WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formula:C28H32N8O3Purezza:99.93%Colore e forma:SolidPeso molecolare:528.61FD274
CAS:FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,Formula:C22H14ClFN6O2SPurezza:98%Colore e forma:SoildPeso molecolare:480.9Thioether-cyclized helix B peptide, CHBP TFA
Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP.Formula:C56H93N19O22S·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:1416.52 (free base)Thioether-cyclized helix B peptide, CHBP
CAS:Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTORFormula:C56H93N19O22SPurezza:98%Colore e forma:SolidPeso molecolare:1416.52YB-3-17
CAS:YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)Formula:C38H39N11O6Colore e forma:SolidPeso molecolare:745.786PI3K-IN-22
CAS:PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.Formula:C31H35F3N8O3Colore e forma:SolidPeso molecolare:624.66mTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFormula:C19H24N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:400.5QL-IX-55
CAS:QL-IX-55 has a wide range of applications in life science related research.Formula:C24H14F4N4OColore e forma:SolidPeso molecolare:450.39Aschantin
CAS:Aschantin is a useful organic compound for research related to life sciences. The catalog number is T126072 and the CAS number is 13060-15-6.Formula:C22H24O7Colore e forma:SolidPeso molecolare:400.427MCX 28
CAS:MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.Formula:C25H19N5O4S3Colore e forma:SolidPeso molecolare:549.64PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withColore e forma:Odour SolidS6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Formula:C16H17BrN6OPurezza:99.99%Colore e forma:SolidPeso molecolare:389.25RMC-5552
CAS:RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.Formula:C93H136N10O24Colore e forma:SolidPeso molecolare:1778.16Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Formula:C35H58N6O9Purezza:98.59%Colore e forma:SolidPeso molecolare:706.87Anti-Phospho-mTOR (Ser2481) Antibody (4R8)
Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.Colore e forma:Odour LiquidAnti-Phospho-MTOR (Ser2448) Antibody (2K503)
Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.Colore e forma:Odour LiquidTemsirolimus
CAS:Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.Formula:C56H87NO16Purezza:97.76% - >99.99%Colore e forma:White Crystalline PowderPeso molecolare:1030.29Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:432.4Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purezza:98.92%Colore e forma:SolidPeso molecolare:338.35PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purezza:97.79% - 99.3%Colore e forma:SolidPeso molecolare:348.36WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Formula:C24H29N7O5Purezza:97.86% - 99.61%Colore e forma:SolidPeso molecolare:495.53Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purezza:97.58% - 98.92%Colore e forma:SolidPeso molecolare:411.38Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formula:C25H17F2N5O3SPurezza:98% - 99.8%Colore e forma:SolidPeso molecolare:505.5BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purezza:95.74% - 99.78%Colore e forma:SolidPeso molecolare:534.53XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Formula:C23H22FN3O4SPurezza:99.39% - 99.53%Colore e forma:SolidPeso molecolare:455.5GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.44Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Formula:C26H46N2OPurezza:97.78% - 98%Colore e forma:SolidPeso molecolare:402.66OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formula:C21H22N6O3Purezza:97.42%Colore e forma:SolidPeso molecolare:406.44PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formula:C22H27N5O4Purezza:96.27% - ≥95%Colore e forma:SolidPeso molecolare:425.48Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formula:C23H26N4O3Purezza:98.41% - 99.69%Colore e forma:SolidPeso molecolare:406.48D-α-Hydroxyglutaric acid disodium
CAS:D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Formula:C5H6Na2O5Purezza:97.16%Colore e forma:SolidPeso molecolare:192.083BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purezza:97.76%Colore e forma:SolidPeso molecolare:327.33GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formula:C21H28N8O3S2Purezza:98.88% - 99.55%Colore e forma:SolidPeso molecolare:504.63Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Formula:C14H20O7Purezza:97.81%Colore e forma:Red-Brown Fine PowderPeso molecolare:300.30Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Formula:C22H28N2O4Purezza:96.83% - 99.93%Colore e forma:SolidPeso molecolare:384.47Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Formula:C43H45BrCl2N3OPPurezza:97.25% - 98.34%Colore e forma:SolidPeso molecolare:801.62GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurezza:98.42% - 99.54%Colore e forma:SolidPeso molecolare:414.48Everolimus
CAS:<p>Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.</p>Formula:C53H83NO14Purezza:97.76% - 99.78%Colore e forma:Off-White To Light Yellow PowdPeso molecolare:958.2225(R,S)-Ruscogenin
CAS:25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.Formula:C27H42O4Purezza:99.32% - 99.40%Colore e forma:SolidPeso molecolare:430.62AZD-8055
CAS:<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Formula:C25H31N5O4Purezza:98% - 99.69%Colore e forma:SolidPeso molecolare:465.54NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Formula:C7H14ClF2NO2Colore e forma:SolidPeso molecolare:217.64Palomid 529
CAS:Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.Formula:C24H22O6Purezza:98.40% - 98.59%Colore e forma:SolidPeso molecolare:406.43KU-0063794
CAS:KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Formula:C25H31N5O4Purezza:98.21% - >99.99%Colore e forma:SolidPeso molecolare:465.54WYE-687 dihydrochloride
CAS:WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).Formula:C28H34Cl2N8O3Colore e forma:SolidPeso molecolare:601.53SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurezza:99.56%Colore e forma:SolidPeso molecolare:336.15L-Leucine
CAS:L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.Formula:C6H13NO2Purezza:99.83%Colore e forma:White Solid CrystallinePeso molecolare:131.17Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Formula:C25H30N6O3Purezza:97.08% - 99.06%Colore e forma:SolidPeso molecolare:462.54Onatasertib
CAS:Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Formula:C21H27N5O3Purezza:99.14% - 99.93%Colore e forma:SolidPeso molecolare:397.47Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurezza:98.21% - 99.69%Colore e forma:SolidPeso molecolare:270.29PP121
CAS:PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Formula:C17H17N7Purezza:98.45% - 99.93%Colore e forma:SolidPeso molecolare:319.36Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purezza:98% - 99.5%Colore e forma:SolidPeso molecolare:855.02Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purezza:98.3% - 99.33%Colore e forma:SolidPeso molecolare:607.62G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formula:C23H30N8O3SPurezza:98.28% - 99.64%Colore e forma:SolidPeso molecolare:498.6Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Formula:C18H11N3O2SPurezza:99.3% - ≥95%Colore e forma:SolidPeso molecolare:333.36Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Formula:C19H17N5O3Purezza:98.41% - 99.5%Colore e forma:SolidPeso molecolare:363.37LY 303511 hydrochloride
CAS:LY 303511 hydrochloride is a potent mTOR inhibitorFormula:C19H19ClN2O2Purezza:98.47%Colore e forma:SolidPeso molecolare:342.82Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Formula:C15H15N7OPurezza:99.19% - >99.99%Colore e forma:SolidPeso molecolare:309.33LY-2584702 free base
CAS:LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).Formula:C21H19F4N7Purezza:98.72% - 99.51%Colore e forma:SolidPeso molecolare:445.42Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Formula:C47H76O16Purezza:98.76% - 99.92%Colore e forma:SolidPeso molecolare:897.1Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purezza:96.66% - 99.93%Colore e forma:SolidPeso molecolare:332.39CDC25B-IN-2
CAS:BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.Formula:C15H12N2O3Purezza:99.12%Colore e forma:SolidPeso molecolare:268.27CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Formula:C15H19N7O3SPurezza:99.41% - 99.87%Colore e forma:SolidPeso molecolare:377.42GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Formula:C24H16Cl2F2N6OPurezza:98.59%Colore e forma:SolidPeso molecolare:513.33Torkinib
CAS:Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Formula:C16H16N6OPurezza:99.11%Colore e forma:SolidPeso molecolare:308.34mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Formula:C16H15BrN2O3Purezza:99.43%Colore e forma:SolidPeso molecolare:363.21Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Formula:C30H48O5Purezza:96.91% - 99.97%Colore e forma:SolidPeso molecolare:488.70TMBIM6 antagonist-1
CAS:TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFormula:C15H12N2O3Purezza:99.26%Colore e forma:SolidPeso molecolare:268.27Zotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Formula:C52H79N5O12Purezza:95% - 98.01%Colore e forma:SolidPeso molecolare:966.21(+)-Usnic acid
CAS:(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.Formula:C18H16O7Purezza:98.22%Colore e forma:SolidPeso molecolare:344.32CZ415
CAS:<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Formula:C22H29N5O4SPurezza:97.54% - 98.36%Colore e forma:SolidPeso molecolare:459.56VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formula:C17H22N8OPurezza:97.82% - 99.54%Colore e forma:SolidPeso molecolare:354.41Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Formula:C15H12O8Purezza:96.68% - 98.229%Colore e forma:SolidPeso molecolare:320.25MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Formula:C17H21N7O4Purezza:97.74% - >99.99%Colore e forma:SolidPeso molecolare:387.39ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Formula:C16H17N5O2Purezza:99.14%Colore e forma:SolidPeso molecolare:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurezza:97.64% - 99.85%Colore e forma:SolidPeso molecolare:469.54PQR620
CAS:PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Formula:C21H25F2N7O2Purezza:97.61%Colore e forma:SolidPeso molecolare:445.47DMH-25
CAS:<p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>Formula:C15H8Br3NO3Purezza:99.26%Colore e forma:SolidPeso molecolare:489.94Ridaforolimus
CAS:<p>Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。</p>Formula:C53H84NO14PPurezza:90.00% - 98.55%Colore e forma:Off-White SolidPeso molecolare:990.21DIM-C-pPhOH
CAS:CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Formula:C23H18N2OPurezza:98.61%Colore e forma:SolidPeso molecolare:338.4CC-115
CAS:CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).Formula:C16H16N8OPurezza:86.79% - 99.01%Colore e forma:SolidPeso molecolare:336.35PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Formula:C18H23F2N7O2Purezza:99.5%Colore e forma:SolidPeso molecolare:407.42PKCβ inhibitor 1
CAS:<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Formula:C24H21N5O2Purezza:99.33%Colore e forma:SolidPeso molecolare:411.46KU-0060648
CAS:KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Formula:C33H34N4O4SPurezza:98.75%Colore e forma:SolidPeso molecolare:582.71Desmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Formula:C16H20N8OPurezza:>99.99%Colore e forma:SolidPeso molecolare:340.38MHY-1685
CAS:<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Formula:C11H8N2O4Purezza:99.76%Colore e forma:SolidPeso molecolare:232.19DS-7423
CAS:<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formula:C22H27F3N10O2Purezza:99.98%Colore e forma:SolidPeso molecolare:520.51Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFormula:C32H41N9O4Purezza:98% - 99.36%Colore e forma:SolidPeso molecolare:615.73ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purezza:97.76%Colore e forma:SolidPeso molecolare:470.52BGT226 maleate
CAS:<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Formula:C28H25F3N6O2·C4H4O4Purezza:97.75% - 98.78%Colore e forma:SolidPeso molecolare:650.6LY 303511
CAS:LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Formula:C19H18N2O2Purezza:98%Colore e forma:SolidPeso molecolare:306.36OXA-01
CAS:OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.Formula:C21H20ClN5O2Colore e forma:SolidPeso molecolare:409.87PI3-Kinase α Inhibitor 2
CAS:Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 andFormula:C16H15N3O2SColore e forma:SolidPeso molecolare:313.37PI3K/mTOR Inhibitor-9
CAS:PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).Formula:C23H27N7O2Colore e forma:SolidPeso molecolare:433.51P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormula:C9H8ClN3OPurezza:99.98%Colore e forma:SolidPeso molecolare:209.63PI3K/mTOR Inhibitor-3
CAS:PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.Formula:C22H23N5OColore e forma:SolidPeso molecolare:373.45PP30
CAS:PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.Formula:C18H19N7OSPurezza:98%Colore e forma:SolidPeso molecolare:381.45PI-540
CAS:PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).Formula:C22H27N5O2SColore e forma:SolidPeso molecolare:425.55PI3K/mTOR Inhibitor-4
CAS:Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.Formula:C27H22FN3O6SColore e forma:SolidPeso molecolare:535.54PI3K/mTOR Inhibitor-13
CAS:PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.Formula:C20H13F2N5O3SColore e forma:SolidPeso molecolare:441.41eCF-309
CAS:eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.Formula:C18H21N7O3Colore e forma:SolidPeso molecolare:383.4PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formula:C20H13ClF2N4O4SPurezza:96.16%Colore e forma:SolidPeso molecolare:478.86PI3K/mTOR Inhibitor-8
CAS:PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.Formula:C23H22N8O4SColore e forma:SolidPeso molecolare:506.54PKI-179 hydrochloride
CAS:PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.Formula:C25H29ClN8O3Colore e forma:SolidPeso molecolare:525QNN33358
CAS:QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.Formula:C21H42O4Colore e forma:SolidPeso molecolare:358.56WJD008
CAS:WJD008 inhibits PI3K/mTOR, blocks cancer cell growth, and has tumor-fighting properties.Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.4FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Formula:C20H26N8OPurezza:98.34% - 98.80%Colore e forma:SolidPeso molecolare:394.47PKI-179
CAS:PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.Formula:C25H28N8O3Colore e forma:SolidPeso molecolare:488.54NVP-BBD130
CAS:NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.Formula:C28H21N5OColore e forma:SolidPeso molecolare:443.5mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formula:C23H21N7OPurezza:98%Colore e forma:SolidPeso molecolare:411.46PI3Ka-IN-5
CAS:PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .Formula:C30H35N9O5Colore e forma:SolidPeso molecolare:601.66AP1867
CAS:AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand coupled to THOX derivatives, facilitating targeted protein interactions and intracellular modulation studies.Formula:C38H47NO11Purezza:99.86%Colore e forma:SolidPeso molecolare:693.78JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Formula:C17H14Cl2FN3OSPurezza:98.33% - 98.33%Colore e forma:SolidPeso molecolare:398.28mTOR inhibitor-3
CAS:mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.Formula:C25H30N8O2Purezza:99% - 99.64%Colore e forma:SolidPeso molecolare:474.56mTOR inhibitor 9d
CAS:mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,Formula:C21H23N5O3SPurezza:98.91%Colore e forma:SoildPeso molecolare:425.5PI3K/mTOR Inhibitor-1
CAS:PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)Formula:C18H22FN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:407.46PI3K/mTOR Inhibitor-7
CAS:Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.Formula:C29H33N9O4Colore e forma:SolidPeso molecolare:571.63PI3K/mTOR Inhibitor-5
CAS:PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.Formula:C32H40N10O3Colore e forma:SolidPeso molecolare:612.73MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formula:C26H30N6O3Purezza:99.97%Colore e forma:SolidPeso molecolare:474.55PI3K/mTOR Inhibitor-12
CAS:PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.Formula:C27H27F2N9O4SPurezza:98%Colore e forma:SolidPeso molecolare:611.62PI3K/mTOR Inhibitor-6
CAS:Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.Formula:C30H34N10O4Colore e forma:SolidPeso molecolare:598.66mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Formula:C21H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:394.47mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFormula:C21H23N5O2SPurezza:99.89%Colore e forma:SoildPeso molecolare:409.5GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formula:C18H22N6O2SPurezza:99.77%Colore e forma:SolidPeso molecolare:386.47PI3K/mTOR Inhibitor-14
CAS:PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, andFormula:C28H30N8O3SPurezza:98%Colore e forma:SolidPeso molecolare:558.66WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Formula:C27H33N7O4Purezza:99.16%Colore e forma:SolidPeso molecolare:519.6WYE-23
CAS:WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).Formula:C26H32N8O4Colore e forma:SolidPeso molecolare:520.58WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Formula:C28H30N8OPurezza:99.88%Colore e forma:SolidPeso molecolare:494.59Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Formula:C25H19BrCl2N2O3SPurezza:99.72%Colore e forma:SolidPeso molecolare:578.3PF-04979064
CAS:<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Formula:C24H26N6O3Purezza:98.20% - ≥98%Colore e forma:SolidPeso molecolare:446.5GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formula:C24H32N6O3Purezza:96.00% - 98.17%Colore e forma:SolidPeso molecolare:452.55PKI-402
CAS:PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.Formula:C29H34N10O3Purezza:99.94%Colore e forma:SolidPeso molecolare:570.65PI3K-IN-37
CAS:PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.51PD-M6
CAS:PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.Formula:C30H39N9O6Colore e forma:SolidPeso molecolare:621.69AZD 3147
CAS:<p>AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).</p>Formula:C24H31N5O4S2Purezza:99.99%Colore e forma:SolidPeso molecolare:517.66mTORC1-IN-1
<p>mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases</p>Purezza:98%Colore e forma:Odour Solid
