Altri inibitori

<p>(11aR)-1,11-Bis(diphenylphosphino)dibenzo[d,f][1,3]dioxepine is a useful organic compound for research related to life sciences and the catalog number is T67396.</p>

<p>1,3-diisopropylurea is a useful organic compound for research related to life sciences and the catalog number is T67077.</p>

<p>Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temperature.</p>

<p>Cy-Tripglu has a wide range of applications in life science related research.</p>

<p>Methanesulfonato[4,6-bis(diphenylphosphino)phenoxazine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67254.</p>

<p>2-Acetamidothiazole is a useful organic compound for research related to life sciences. The catalog number is T67350 and the CAS number is 2719-23-5.</p>

<p>Thalidomide-NH-PEG4-Ms: cereblon ligand + linker, for PROTAC BCL-XL degrader XZ739.</p>

<p>Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine is a useful organic compound for research related to life sciences. The catalog number is T66183 and the CAS number is 1160861-53-9.</p>

<p>Guanylthiourea is a useful organic compound for research related to life sciences. The catalog number is T64909 and the CAS number is 2114-02-5.</p>

<p>4,4-Dimethyl-2-cyclopenten-1-one, derived from Apocyniveneti Folium, exhibits enhanced tumor-specific cytotoxicity [1].</p>

<p>2-(3-Ethoxy-4-(ethoxycarbonyl)phenyl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T67483 and the CAS number is 99469-99-5.</p>

<p>2-([1,1-Biphenyl]-4-yl)-5-phenyl-1,3,4-oxadiazole is a useful organic compound for research related to life sciences. The catalog number is T66233 and the CAS number is 852-38-0.</p>

<p>3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66115 and the CAS number is 5409-58-5.</p>

<p>2-Methoxyethyl 3-oxobutanoate is a useful organic compound for research related to life sciences. The catalog number is T67432 and the CAS number is 22502-03-0.</p>

<p>Ethyl 4-hydroxycyclohexanecarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65155 and the CAS number is 17159-80-7.</p>

<p>N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66203 and the CAS number is 356068-86-5.</p>

<p>Stibosamine is a bioactive chemical.</p>

<p>Triethyl 2-phosphonopropionate is a useful organic compound for research related to life sciences. The catalog number is T65480 and the CAS number is 3699-66-9.</p>

<p>4-Iodo-N-[(phenylmethoxy)carbonyl]-L-phenylalanine (catalog number T66874, CAS number 220400-04-4) is a valuable organic compound for life sciences research.</p>

<p>Phenarsone sulfoxylate is a biochemical.</p>

<p>MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor used to study conditions linked to muscle wasting, encompassing both skeletal and cardiac muscle atrophy [1].</p>

<p>2-Amino-5-chloropyridine is a useful organic compound for research related to life sciences. The catalog number is T67468 and the CAS number is 1072-98-6.</p>

<p>Zolimidine, an imidazopyridine derivative, functions as an orally active antiulcer agent. It promotes mucus secretion in intestinal mucosal cells and enhances the intestinal wall's resistance to ulceration. Studies demonstrate its gastroprotective effect in duodenal ulcer research [1] [2].</p>

<p>Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).</p>

<p>NT 2 Toxin is a useful organic compound for research related to life sciences. The catalog number is T124258 and the CAS number is 76348-84-0.</p>

<p>5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67591 and the CAS number is 25961-11-9.</p>

<p>Methyl 2-(4-bromophenyl)quinoline-4-carboxylate is a useful organic compound for research related to life sciences and the catalog number is T64719.</p>

<p>Azido-PEG3-C-Boc is a PEG-based linker for PROTACs that connects two essential ligands, crucial for the formation of PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.</p>

<p>Fos-Mea-10 is a useful organic compound for research related to life sciences. The catalog number is TF0021 and the CAS number is 557788-85-9.</p>

<p>A031: PROTAC AR degrader, IC50 &lt; 0.25 μM, inhibits prostate cancer growth in zebrafish.</p>

<p>(S)-2-Acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is a valuable organic compound for life sciences research [Catalog: T65171, CAS: 1027-28-7].</p>

<p>ER degrader 2: Potent estrogen receptor disruptor; key for cancer research.</p>

<p>(E)-3-(4-Chlorophenyl)acrylaldehyde is a useful organic compound for research related to life sciences. The catalog number is T67458 and the CAS number is 49678-02-6.</p>

<p>(R)-2-Amino-3-(pyridin-4-yl)propanoic acid is an essential organic compound for life sciences research, catalog number T67056, CAS number 37535-50-5.</p>

<p>N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide is a useful organic compound for research related to life sciences. The catalog number is T66071 and the CAS number is 799842-07-2.</p>

<p>Z-Lys(Boc)-OH is a useful organic compound for research related to life sciences. The catalog number is T65876 and the CAS number is 2389-60-8.</p>

<p>Boc-NH-PEG7-acid, a PEG-based linker for PROTACs, connects two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>(E)-Ethyl 3-(pyrrolidin-1-yl)but-2-enoate is a useful organic compound for research related to life sciences. The catalog number is T65149 and the CAS number is 54716-02-8.</p>

<p>Carbamic acid, N-(O,O-dimethylphosphorothioyl)-N-methyl-, m-isopropylphenyl ester is a bioactive chemical.</p>

<p>Boc-Phe-ONp is an amino acid derivative and has a wide range of applications in life science related research.</p>

<p>3,4-Difluorobenzamide is a useful organic compound for research related to life sciences. The catalog number is T66971 and the CAS number is 85118-04-3.</p>

<p>Cinnamyl chloride is a useful organic compound for research related to life sciences. The catalog number is T64913 and the CAS number is 2687-12-9.</p>

<p>Anticancer agent 11 suppresses angiogenesis and induces DNA cross-links for broad-spectrum efficacy.</p>

<p>Thalidomide-O-amido-PEG3-C2-NH2 TFA, a cereblon ligand-PEG linker for PROTAC, is synthesized.</p>

<p>Azide-PEG-amine (MW 5000) is a polyethylene glycol (PEG)-derived linker compound with azide functionality, primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].</p>

<p>SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 &amp; 6.6 nM; it hinders cancer cell movement and promotes apoptosis.</p>

<p>3-((2-(2-Chlorophenyl)-2-hydroxyethyl)amino)-3-methylbutanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64403 and the CAS number is 2172852-92-3.</p>

<p>Cl-PEG6-acid is a PEG-based linker for PROTACs that connects two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R is a useful organic compound for research related to life sciences and the catalog number is T64611.</p>

<p>1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a useful organic compound for research related to life sciences. The catalog number is T66890 and the CAS number is 1021-25-6.</p>

<p>Ethyl 6,7-difluoro-1-methyl-4-oxo-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65447 and the CAS number is 113046-72-3.</p>

<p>Gynosaponin V is a useful organic compound for research related to life sciences. The catalog number is T126218 and the CAS number is 1207861-73-1.</p>

<p>5H-Dibenz[b,f]azepine-10,11-dione is a useful organic compound for research related to life sciences and the catalog number is T64469.</p>

<p>2-Chloro-1-(2,4-difluorophenyl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T64939 and the CAS number is 51336-94-8.</p>

<p>TLR7/8 agonist-7d is a useful organic compound for research related to life sciences and the catalog number is T64606.</p>

<p>Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.</p>

<p>DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.</p>

<p>N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based compound employed in PROTAC synthesis.</p>

<p>CAY10736: Anticancer agent, blocks cell growth &amp; migration in various cancers, effective in mouse models.</p>

<p>m-PEG10-CH2COOH, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T67589 and the CAS number is 67914-60-7.</p>

<p>Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.</p>

<p>Melitane (Acetyl Hexapeptide-1) acetate is a useful organic compound for research related to life sciences and the catalog number is T64676.</p>

<p>Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].</p>

<p>(S)-2-((tert-Butoxycarbonyl)amino)-3-(2-methoxyphenyl)propanoic acid is a useful organic compound for research related to life sciences and the catalog number is T67248.</p>

<p>(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid is a useful organic compound for research related to life sciences. The catalog number is T67178 and the CAS number is 1012341-48-8.</p>

<p>Camphorquinone (CQ) is a widely used photoinitiator in dental materials.</p>

<p>Azido-PEG5-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>3,5-Pyridinedicarboxylic Acid is a useful organic compound for research related to life sciences. The catalog number is T66974 and the CAS number is 499-81-0.</p>

<p>2-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T64717 and the CAS number is 2103656-92-2.</p>

<p>m-PEG6-amino-Mal is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>Undecyl-β-D-Selenomaltoside is a useful organic compound for research related to life sciences. The catalog number is TF0049 and the CAS number is 1423294-14-7.</p>

<p>10× TBS (PH7.4) is a reagent and has a wide range of applications in life science related research.</p>

<p>GLF16 is a hydrophilic fluorescent SBB analog and robustly identifies senescence. It enables the use of flow cytometry and live cell sorting for rapid senescent cell detection. GLF16 is suitable for in vivo identification, isolation, and downstream characterization of senescent cell populations at the single-cell level in various biological materials.</p>

<p>Carbostyril 124 is a useful organic compound for research related to life sciences. The catalog number is T65062 and the CAS number is 19840-99-4.</p>

<p>HDAC3/6-IN-2 inhibits HDAC6/3 with IC50s 0.368/0.635 μM; promotes cancer cell apoptosis and histone acetylation.</p>

<p>(S)-4-Phenoxydinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine is a useful organic compound for research related to life sciences and the catalog number is T65991.</p>

<p>2,2'-(2-Hydroxypropane-1,3-diyl)bis(isoindoline-1,3-dione) is a useful organic compound for research related to life sciences. The catalog number is T67040 and the CAS number is 73825-95-3.</p>

<p>N-(2,4-Dichloro-5-hydroxyphenyl)acetamide is a useful organic compound for research related to life sciences. The catalog number is T65326 and the CAS number is 67669-19-6.</p>

<p>NH-bis(C2-PEG2-NH-Boc) is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system in cells.</p>

<p>3,5-Dimethyl-4-nitropyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T67494 and the CAS number is 14248-66-9.</p>

<p>4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67079 and the CAS number is 139756-02-8.</p>

<p>18-Hydroxycortisol: adrenal steroid, cortisol derivative, studied in primary aldosteronism.</p>

<p>5-Bromo-2-(2H-tetrazol-5-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T64895 and the CAS number is 380380-60-9.</p>

<p>Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr</p>

<p>Questiomycin A derivatives 14 is a Questiomycin A derivative.</p>

<p>2-(3-(4-Methylbenzoyl)phenyl)propanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64773.</p>

<p>Bis(2-(3,5-dimethylphenyl)quinoline-C2,N')(acetylacetonato)iridium(III) is a useful organic compound for research related to life sciences and the catalog number is T67276.</p>

<p>Ethyl 2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T64927 and the CAS number is 53554-29-3.</p>

<p>(2R,4R)-4-Methylpiperidine-2-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65603 and the CAS number is 74892-81-2.</p>

<p>PEG3-C4-OBn, a polyethylene glycol (PEG)-based PROTAC linker, is utilized in crafting the PROTAC SGK3 degrader-1, a potent SKG3 degrader leveraging PROTAC technology [1][2].</p>

<p>1,4-Bis(4-nitrophenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T64560 and the CAS number is 16264-05-4.</p>

<p>GCLE is a useful organic compound for research related to life sciences. The catalog number is T65660 and the CAS number is 104146-10-3.</p>

<p>Tetraethylammonium hexachlorocerate(IV) is a useful organic compound for research related to life sciences and the catalog number is T64591.</p>

<p>m-PEG-triethoxysilane (MW 5000) is a polyethylene glycol-based PROTAC linker suitable for synthesizing PROTACs[1].</p>

<p>GSHtracer is a ratiometric probe designed for the quantification of glutathione (GSH) concentrations. This probe demonstrates a measurable shift in its excitation-emission profile, specifically from 520/580 nm to 430/510 nm, upon binding with GSH.</p>

<p>N-Carbobenzoxy-4-hydroxy-D-2-phenylglycine (catalog number T66184, CAS number 26787-75-7) is a valuable organic compound for research in the life sciences.</p>

<p>22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]</p>

<p>BPH-252 is a bioactive chemical.</p>

<p>Activates Notch pathway, boosts NSC self-renewal and neurogenesis, enhances mice memory.</p>