Altri inibitori

1-(Piperidin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one is a useful organic compound for research related to life sciences and the catalog number is T66378.

<p>Benzyl (4-bromo-3-fluorophenyl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66461 and the CAS number is 510729-01-8.</p>

<p>Diacetato[(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) is a useful organic compound for research related to life sciences. The catalog number is T66567 and the CAS number is 325146-81-4.</p>

7-TMCA is a useful organic compound for research related to life sciences. The catalog number is T65878 and the CAS number is 24209-38-9.

Enrofloxacin hydrochloride is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis.

Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.

3-[2-(Trifluoromethyl)phenyl]propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65989 and the CAS number is 94022-99-8.

7-Amino-2H-chromen-2-one is a useful organic compound for research related to life sciences and the catalog number is T64948.

BnO-PEG4-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Perhydroazepinone hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66790 and the CAS number is 50492-22-3.

<p>22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]</p>

<p>1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T66913 and the CAS number is 221615-75-4.</p>

<p>Water-18O is a useful organic compound for research related to life sciences and the catalog number is T64656.</p>

<p>HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.</p>

<p>HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>Bikunin/AMBP Protein, Human, Recombinant (aa 1-203, His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta).</p>

Intermediates and building blocks - phosphorous compounds; nucleophile

<p>BCL-W Protein, Human, Recombinant (His) is expressed in E.</p>

<p>LPL Protein, Chinese hamster, Recombinant (His) is expressed in E.</p>

<p>Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and</p>

<p>Heterocyclic compounds-pyridine,</p>

<p>S100A8 &amp; S100A9 Heterodimer Protein, Human, Recombinant (Flag &amp; His) is expressed in Baculovirus insect cells with Flag and His tag.</p>

<p>R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes.</p>

<p>CF502 (STING agonist-23) is a non-nucleotide that activates STING pathway, boosts immune responses, and shows activity against SARS-CoV.</p>

<p>Valiloxibic acid is a prodrug for GHB, a natural psychoactive neurotransmitter and weak GABAB agonist.</p>

<p>Alpha-Synuclein Protein, Human, Recombinant is expressed in E.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Lipocalin-2/LCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Hantaan virus HTNV (strain 84FLi) Nucleocapsid/NP Protein (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.</p>

<p>7-Methoxy-1-tetralone may have insecticidal activity.</p>

<p>MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.</p>

<p>10Z-Nonadecenoic acid is a long-chain fatty acid with anti-tumor activity.</p>

<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>

<p>Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-focused peptide that curbs toxic ROS and stabilizes cardiolipin.</p>

<p>Dimethylamine hydrochloride, found in urine, comes from food compound TMAO and NO synthesis inhibitor ADMA, processed by DDAH enzyme.</p>

<p>NBQX (FG9202), an AMPA/kainate receptor blocker, counters glutamate toxicity; water-soluble as disodium salt, has anticonvulsant properties.</p>

<p>Tropinone used as an intermediate in the synthesis of atropine sulfate, and is a decane alkaloid.</p>

<p>Elamipretide 2TFA (RX-31 2TFA) is a novel mitochondrion-targeted antioxidant.</p>

<p>α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation.</p>

Decyl-TPP bromide ((1-Decyl)triphenylphosphonium bromide) may be used as an intermediate for chemical synthesis and an inactive control or as a reference to

<p>Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C</p>

<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>

<p>4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.</p>

<p>FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>SLC1A2 Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is P43006.</p>

<p>IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. IGFBP-1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.9 kDa and the accession number is P21743.</p>

<p>May act as a negative regulator of collagen matrix deposition.</p>

<p>Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].</p>

CK176 is an HIV-1 inhibitor, 11x more effective than I-XW-053 in human PBMCs.

Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity.

FM-24 HCl is a long acting beta-adrenergic receptor antagonist.

<p>PS372424 activates CXCR3, triggers ERK phosphorylation, and inhibits CXCL11's effect on CD45+ cell migration in humanized mice.</p>

<p>Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties.</p>

<p>Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.</p>

PSB-6426 is the first potent and selective human nucleoside triphosphate diphosphohydrolase-2 inhibitor.

H 35-25 is a beta 2-antagonist.

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.

<p>BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (</p>

<p>Benzovindiflupyr: a fungicide that inhibits SDH (IC50=5.2nM), halts S. sclerotiorum growth (EC50=0.011μg/ml), and protects crops like eggplants.</p>

<p>(E)-Crotylbarbital, a Crotylbarbital isomer, is a sedative with hypnotic, anticonvulsant properties, aiding sleep and mental stability.</p>

<p>Albuterol stearate, a salt form of Albuterol, is a selective beta2 agonist for treating asthma and COPD, with 29x preference for beta2 over beta1.</p>

IDX-375, a HCV NS5B polymerase inhibitor, is used potentially for the treatment of HCV infection.

MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).

<p>Questiomycin A derivative 18 TFA exhibits antibacterial, anticancer properties and inhibits GRP78.</p>

<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>

<p>Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.</p>

<p>Erythrityl Tetranitrate, a vasodilator similar to nitroglycerin, was first in "sustained release" tablets; may cause "nitro headache."</p>

<p>Phenazolam is an analytical reference standard categorized as a benzodiazepine. [1] This product is intended for research and forensic applications.</p>

<p>KP372-1, an Akt inhibitor, blocks PI3K signaling, arrests cell growth, and triggers apoptosis in head/neck squamous cell carcinoma.</p>

Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties.

<p>PL265 is a long-acting dual ENKephalinase inhibitor (DENKi) with analgesic potential.</p>

D(-)-Octopamine CSA salt is an agonist of octopamine receptors.

Fosfonet sodium is a sodium salt of phosphonoacetic acid, effective against herpesviruses by inhibiting viral DNA polymerase.

CH-100 is a Chinese herbal medicine previously used in the treatment of human hepatitis C.

<p>Radafaxine hydrochloride is an inhibitor of DAT and NET transporters, and nAChR family modulator.</p>

<p>Culmerciclib is a cell cycle protein-dependent kinase (CDK) inhibitor that exhibits antitumour effects.</p>

DPX-3778, a triethanolamine salt, boosts tobacco callus growth 4-5x at 0.124-2.48 μM and slows aging with IAA and kinetin.

TRPP3 channel inhibitor

Guancydine is an antihypertensive agent.

<p>PAD4-IN-2 (compound 5i) is a PAD4 inhibitor with an IC50 value of 1.94 μM, shown to suppress tumor growth in mice through specific inhibition of the PAD4-H3cit-</p>

Aminobutane bisphosphonate curbs bone loss; may manage hypercalcemia in cancer.

(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride, a potent antagonist of proNGF (nerve growth factor).

<p>AKOS-22: potent VDAC1 inhibitor, Kd=15.4 μM; prevents mitochondrial dysfunction and apoptosis.</p>

<p>HPK1-IN-18: Potent, specific inhibitor of HPK1, a MAP4K enzyme, for cancer research and treatment.</p>

<p>FLT3-IN-19 (Comp 50) is a potent, selective inhibitor of FLT3, demonstrating an IC50 value of 0.213 nM, and is applicable in research pertaining to acute</p>

<p>Azilsartan medoxomil potassium (QR-01019K), an angiotensin II receptor antagonist, exhibits a potent and sustained antihypertensive effect, along with a more</p>

<p>SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2, displaying strong anti-tumor activity with an IC50 of 7 nM.</p>

<p>Anti-MI/R injury agent 1 (compound 18), derived from Panaxatriol, represents an orally administered, potent agent against myocardial ischemia/reperfusion (MI/R</p>

<p>RIOK2-IN-2 (8) functions as an inhibitor of RIOK2, exhibiting IC50 values of 3.02 μM in MKN-1 cells and 5.34 μM in MOLT4 cells [1].</p>

<p>Antibacterial Agent 160 is a potent antibacterial agent that rapidly eradicates bacteria and inhibits the formation of bacterial biofilms.</p>

<p>Tauro-obeticholic acid, a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid, is an active metabolite of obeticholic acid.</p>

Omeprazole treats GERD, ulcers, Zollinger-Ellison syndrome, prevents GI bleeding; it's a proton pump inhibitor.

<p>URAT1 Inhibitor 5 (compound 16) serves as a powerful inhibitor of URAT1 and is utilized in hyperuricemia research [1].</p>

<p>Compound B12 (Antibacterial agent 157) is a fungicidal agent that can impact protein synthesis in Botrytis cinerea.</p>

<p>Ac4GalNAlk, a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE), facilitates the detection of protein glycosylation by promoting nucleotide-sugar biosynthesis and enhancing bioorthogonal cell surface markers. It is activated by cellular biosynthetic machinery into nucleotide sugars, subsequently enabling the tracing of glycoproteins in bioorthogonal chemistry [1].</p>

<p>Antitumor Agent-136 (Compound 17), a broad-spectrum antitumor agent and NAMPT inhibitor, exhibits potent activity with an IC50 of 9.5 nM. It efficiently lowers intracellular and extracellular NAMPT protein levels via the ubiquitin proteasome pathway, achieving effective tumor inhibition [1].</p>

<p>Civorebrutinib (WS-413) is an inhibitor of Bruton's tyrosine kinase that exhibits antineoplastic activity [1].</p>

<p>DDO-2213 is a potent, orally active inhibitor of the WDR5-MLL1 interaction, demonstrating an IC50 of 29 nM and a Kd of 72.9 nM against WDR5.</p>

<p>And1-IN-1, also known as compound III, is a potent inhibitor of And1 [1].</p>

<p>LM2I, a derivative of Spinosyn A (SPA), serves both as an argininosuccinate synthase (ASS1) enzyme activator and a tumor inhibitor through direct interaction</p>

<p>DiaFluo is a probe for protein S-sulfinylation from cells.</p>

<p>CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties.</p>

<p>LT-540-717 (compound 32), a potent FLT3 inhibitor (IC50=0.62 nM), exhibits antiproliferative activity and effectively inhibits various acquired FLT3 mutations,</p>

<p>FOXM1-IN-2, a FOXM1 inhibitor, exhibits antineoplastic activity [1].</p>

<p>Compound 11, also known as Antitumor Photosensitizer-2, is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-</p>

HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).

<p>80-O16B, an ionizable cationic lipid featuring disulfide bonds, is utilized in the preparation of lipid nanoparticles (LNP) [1].</p>

<p>Immune cell migration-IN-1 (compound 2) serves as a potent inhibitor of immune cell migration, with potential research applications for mitigating conditions</p>

<p>CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM.</p>

<p>BET-IN-1 is a bromodomain inhibitor extracted from patent WO/2013024104A1 (example 2, plC50: 6.0 - 7.0).</p>

<p>S-72 acts as a microtubule polymerization inhibitor, effective in cell-free assays at concentrations of 1, 3, and 10 µM.</p>

L 689037 is an inhibitor of leukotriene biosynthesis.