Segnalazione citoscheletrica

SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 …

H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).

BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory …

Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential …

Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport …

Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.

CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.

Mivobulin is an inhibitor of tubulin .

EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be …

DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.

Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer …

CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).

PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)

(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for …

Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization.

3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an …

LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM …

HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with …

TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective …

Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, …

Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 …

ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from …

Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum.

BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.

Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.

PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, …

AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 …

Taltobulin (HTI-286) is a potent tubulin inhibitor.

KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.

AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).

Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.

ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and …

CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor (IC50s: …

CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase (IC50s: 2 nM and …

Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 …

Abciximab (C7E3) is a mouse/human chimeric monoclonal antibody that is a potent glycoprotein IIb/IIIa inhibitor. …