Composti deuterati

<p>Applications 5-Chloro-2-methoxy-benzoic Acid Methyl Ester-13C2,d6 (cas# 1794737-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Naphthalenecarboxylic Acid-13C6 (cas# 1346602-42-3) is a compound useful in organic synthesis.<br></p>

<p>Applications A deuterated intermediate in the synthesis of Carisoprodol.<br></p>

<p>Applications Adenose N-Oxide and its derivatives are used as an active ingredient in the preparation of therapeutic agents for inflammatory diseases and inhibitors of adenosine kinase.<br>References Long, M. &amp; Parker, W.: Biochem. Pharmacol., 71, 1671 (2006)<br></p>

<p>Applications Potassium Azide-15N is a labelled intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1, which is the labeled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.<br>References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991), Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001),<br></p>

<p>Applications 4-[[6-Chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-d8 is an intermediate from the synthesis of Etravirine-d8 (E937003). Etravirine-d8 is a novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008); Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008)<br></p>

<p>Applications Dimethyl-d6-(tetrahydro-3,3-diphenyl-2-furylidene)ammonium Bromide is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases.<br>References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997);<br></p>

<p>Applications 5-Nitro-1H-imidazole-1-ethanol-d4 (cas# 1794791-19-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.<br>References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),<br></p>

<p>Applications 4-Bromotoluene-2,3,5,6-D4 is used in the synthesis of some deuteriated benzene derivatives like isotopically labelled ZD4054 used to support the development of drug metabolism and pharmokinetics program.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bergin, J. A., et al.: Journal of Label. Compds Radiopharm., 50, 431 (2007); Renaud, R. N., et al.: Canadian J. Chem., 39, 21 (1961)<br></p>

<p>Applications 2-Chloro-ethanamine-d4 Hydrochloride (cas# 172333-26-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2-Aminothiazol-4-yl)acetic Acid-13C, 15N2 Hydrochloride is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications p-Vinylguaiacol-d3 is the isotope labelled analog of p-Vinylguaiacol (V424960); an aromatic substance, one of the compounds responsible for the natural aroma of buckwheat, and also one of the major pyrolytic products of (E)-N-[(4-hydroxy-3-methoxy)-phenethyl]-3-[(3-methoxy-4-O-β-D-glucopyranosyloxy) phenyl] acrylamide; a new gycloside in tobacco.<br>References Janes, Damjan., et al.: Food Chem., 112(1), 120-124 (2009); Zhou, Rong., et al.: Yancao Keji, (7), 34-36, 42 (2013)<br></p>

<p>Applications Labelled Potassium Hydroxide, used in the synthesis of biodiesels.<br>References Boz, N. et al.: Appl. Catal. B-Environ., 138, 236 (2013); Rathore, P. et al.: Energy. Fuels. 27, 2776 (2013);<br></p>

<p>Applications A labelled intermediate in the syntheis of a metabolite of the anti-cancer drug Tamoxifen.<br></p>

<p>Stability Hygroscopic<br>Applications Tiglylcarnitine-d3 is labelled Tiglylcarnitine (T793780), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Tiglylcarnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Cyclohexanol-d11 is the deuterated analog of cyclohexane, general organic chemical solvent. It is also used as a precursor to the synthesis of nylon.<br>References Hiroshi O. et al.: J. Memb. Sci., 105, 51 (1995); Rekharsky, M.V. et al.: J. Am. Chem. Soc., 124, 12361 (2002)<br></p>

<p>Applications Isotope labelled Hexahydro-1,3-isobenzofurandione is used in the synthesis of hypotensive agents, pyridazinones. Also used in the synthesis of selective PDE4 inhibitors.<br>References Curran, W. et al.: J. Med. Chem., 17, 273 (1974); Van der Mey, M. et al.: J. Med. Chem., 44, 2511 (2001);<br></p>

<p>Applications 2-(Benzoyloxy)ethyl-d4 Benzoate is an intermediate in the synthesis of Acyclovir-d4 (A192402), an orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Applications It is the labeled analogue of Indocyanine Green (I697000), a tricarbocyanine type of dye with infrared absorbing properties that can be used as a diagnostic aid (blood volume determination, cardiac output, hepatic function).<br>References Papageorgiou, P., et al.: Br. J. Dermatol., 142, 973 (2000), Dreno, B., et al.: Dermatology, 203, 135 (2001), Gollnick, H., et al.: Drugs, 63, 1579 (2003), Seaton, E., et al.: Lancet, 362, 1347 (2003),<br></p>

<p>Applications Monomethyl Glutarate-1,5-13C2 (cas# 1189708-76-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled 2-Bromo-5-picoline (B685570). Used for preparation of [[(triazolylmethyl)pyridyl]phenyl]tetrazoles and related compounds as cardiovascular agents.<br>References Behforouz, M., et al.: J. Med. Chem., 46, 5773 (2003), Behforouz, M., et al.: Bioorg. Med. Chem., 15, 495 (2007),<br></p>

<p>Applications O-2-Amino-2-methylpropyl Bilastine-d6 is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.<br>References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),<br></p>

<p>Applications Cyanoacetic Acid-13C2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications (3,3,4,4,4-d5)-(E/Z)-1-[4-(2-Chloroethoxy)phenyl]-1-[4-(t-butyldimethylsilyloxy)phenyl]-2-phenyl-1-butene (cas# 1020719-26-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 1’-Hydroxy N-Trityl Medetomidine-d3 is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.<br>References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)<br></p>

<p>Applications Used in cosmetic compositions.<br>References Chasin, M., et al.: Biopharm. Manufacturing, 1, 33 (1988), Cohen, S., et al.: Pharm. Res., 8, 713 (1991), Anderson, J., et al.: Eur. J. Pharm. Biopharm., 40, 1 (1994), Park, H., et al.: Pharm. Res., 13, 1770 (1996),<br></p>

<p>Applications N-Methyl-o-phenylenediamine-d3, Dihydrochloride (cas# 1246820-22-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Reagent used to make labelled Catechol.<br></p>

<p>Applications (Z)-2-(Methoxyimino)-3-oxobutanoic Acid-d3 Methyl Ester (cas# 1331636-65-7) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate in the production of labelled fluorothymidine derivatives<br>References Roberts, G., et al.: Biochem. Pharmacol., 46, 2209 (1993), Hatano, A., et al.: Bioorg. Med. Chem., 16, 3866 (2008),<br></p>

<p>Applications Ethyl 4-Chlorobutyrate-d4 is an isotope labelled reagent used in the preparation of cyclopropane derivatives.<br>References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),<br></p>

<p>Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N,N-dimethyl-d6-amine (cas# 1190006-94-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Benzyldiethylamine-d4 is an intermediate in the synthesis of labelled N-Nitrosodiethylamine (N525465), a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.<br>References Forbush, B., et al.: J. Bio. Chem., 263, 7979 (1988);<br></p>

<p>Applications 2,2-Dimethylbutyric-d11 Acid (CAS# 1219804-04-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl 2-Bromo-2-methylpropanoate-D6 is an intermediate in the synthesis of Aztreonam-d6 (A965202), which is an isotope labeled Azetreonam (A965200), the first totally synthetic monocyclic β-lactam antibiotic.<br>References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),<br></p>

<p>Applications N-Methylaminophthalimide-d3 is the labeled analogue of N-Methylaminophthalimide (M287295), which is used in the preparation of 2:1-[α/aza]-oligomer precursors.<br>References Abbas, C., et. al.: Tetrahedron Lett., 50, 4158 (2009)<br></p>

<p>Applications 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester-d5 is labelled 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester (T302660) which is used as a reagent to prepare N-heterocyclylcarbamates and biphenylisoxazoles as lysophosphatidic acid (LPA) receptor antagonists.<br>References Buckman, B., et al.: PCT Int. Appl., WO 2013025733 A1 20130221 (2013)<br></p>

<p>Applications Diethylamine-13C4 Hydrochloride is the labelled salt of Diethylamine (D443485).<br></p>

<p>Applications 2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of Lapatinib-d7 Dihydrochloride (L175807), which is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic;Also, it is used in the preparation of 4-Aminoquinazolines as EGFR and HER-2 inhibitors.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005); Tung, R.: PCT Int. Appl. (2008), WO 2008024439 A2 20080228<br></p>

<p>Applications 2-Hydroxypyridine-N-oxide-d5 is the labelled analogue of 2-Hydroxypyridine-N-oxide (H953633), a reactant that is useful along wtih (S)-1-phenylethylamine and EDC·HCl for the synthesis of AZD8186, a potent and selective Inhibitor of PI3Kβ and PI3Kδ.<br>References B. Barlaam., et al.: J. Med. Chem., 58, 943-62 (2015);<br></p>

<p>Applications 1-Bromooctane-d17 (CAS# 126840-36-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Di-n-decyl Phthalate-3,4,5,6-d4 (CAS# 1276197-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Bromotoluene-2,4,6-d3 (CAS# 1219805-60-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4-Dichloroaniline-d2 (cas# 1219803-22-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diethylamine-d11 (CAS# 1173019-51-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-2,2,3,3,3-d5 is an isotope labelled analog of 1-Bromopropane (B687135); a solvent used for the cleaning of metal surfaces and removal of soldering residues from electronic circuit boards. It is anticipated to be a human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lingyo, Zh., et al.: Toxicology, 304, 76 (2013); Samukawa, M., et al.: Archives Internal Med., 172(16), 1257 (2012)<br></p>

<p>Applications n-Nonanoic-9,9,9-d3 acid is labelled n-Nonanoic Acid (N649385) which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers.<br>References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009)<br></p>

<p>Applications 2-Bromoacetamide-13C2 is the labelled form of 2-Bromoacetamide (B679063). 2-Bromoacetamide is a disinfectant by-product.<br>References Lv, Lu., et al.: Environ. Pollut., 205, 291-298 (2015).<br></p>

<p>Applications 2-Chlorobenzoyl Chloride-d4 is an intermediate for the synthesis of Clofentezine-d8 (C585616), which is a labelled form of Clofentezine which is used in agriculture for the protection of ornamentals, food and non-food crops in the field. Used as a standard for Pesticide detection. Clofentezine is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Bakirci, G.T., et al.; Food. Chem., 135, 1901 (2012); Ay, R., et al.: Insect. Sci., 18, 503 (2011);<br></p>

<p>Applications 1-Heptyne-6,6,7,7,7-d5 (CAS# 83418-35-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 3-Hydroxy-3-methyl-d3-butyrate-4,4,4-d3 (CAS# 30385-86-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications Isotope Labelled Ethaboxam is a pesticide used as a fungicide against fungal infections in crops.<br>References Kim, D. et al.: Pest Manage. Sci., 60, 1007 (2004); Park, M. et al.: J. Microbiol. Biotech., 13, 43 (2003);<br></p>

<p>Applications o-Xylene-alpha,alpha,alpha,alpha',alpha',alpha'-d6 (CAS# 25319-54-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Indole-2,4,5,6,7-d5-3-acetic-alpha,alpha-d2 Acid (CAS# 1173020-21-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone Hexanoate-d11 is the isotopic analog of Testosterone Hexanoate. Testosterone Hexanoate is a metabolite of testosterone(T155000), which is used in analytical studies to determine the use of anabolic steroid esters and related compounds in equine hair sample though ultra high performance liquid chromatography-tandem mass spectrometry.<br>References Gray, B.P., et al.: Analtica Chemica Acta, 787, 163 (2013); McKinney, A., et al.: Bioanalysis 1, 785 (2009)<br></p>

<p>Applications Isotope labelled tert-Butylbenzene is a component of the model diesel fuel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiao, Jing, et al.: Indus. &amp; Eng. Chem. Res., 51(8), 3436-3443 (2012)<br></p>

<p>Applications tert-Butyl-d9 Acrylate (CAS# 928163-00-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyric-4,4,4-d3 Acid (CAS# 36789-14-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Suberylglycine-2,2-d2 (CAS# 1219799-02-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyceryl-d5 Trihexadecanoate (CAS# 60763-98-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzyl-d6 Alcohol (CAS# 1071809-48-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Cortisol-d4 21-Sulfate (C696320). Cortisol 21-Sulfate is a phase II metabolite of Cortisol (H714615).<br>References Spielgelhalder, B., et al.: J. Steroid Biochem., 7, 749 (1976), Vanluchene, E., et al.: J. Chromatogr., 456, 175 (1988), Choi, M., et al.: Steroids, 65, 54 (2000),<br></p>

<p>Applications 4-Fluorobenzyl-2,3,5,6-d4-amine (CAS# 1219798-96-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Tetracontane-d82 (CAS# 1219802-99-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Undecanoic-11,11,11-d3 Acid (CAS# 1219802-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Iodopropane-1,1-d2 (CAS# 25493-14-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Dimethyl Phthalate (D477975). It is used as insect repellent.<br>References Iselin, B., et al.: Helv. Chim. Acta., 40, 373 (1957),<br></p>

<p>Applications Benzyl-2,3,4,5,6-d5 Acetate (CAS# 1398065-57-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium-d5 Chloride is an intermediate used in the synthesis of Girard’s Reagent P-d5 (G388502), which is a labeled girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H. et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R. et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications 2,3-Dihydro-2-[3-(2-phenoxyethoxy)phenyl]-4(1H)-quinazolinone-D5is the isotopic labelled analog of 2,3-Dihydro-2-[3-(2-phenoxyethoxy)phenyl]-4(1H)-quinazolinone.<br></p>