Tossicologia

Applications Desaminosulfonyl N-Acetyl-dorzolamide is an intermediate in the synthesis of Dorzolamide N-Sulfonamide Dimer (D535110), which is a by-product from in-process test for synthesis of dorzolamide hydrochloride.
References Thomas, S., et al.: At-Process, 2, 432 (1997)

Applications L-Xylose is part of the chemical profile of a polysaccharide extracted in aquatic life that shows anti-viral activites against herpes simplex virus 1 & 2 as well as influenza A virus. This is the L-[13C5]Xylose labeled analog.
References Lee, J.B. et al.: Biol. Pharm. Bullet., 29, 2135 (2006);

Applications N-Oleoyl Taurine which belongs to the class of N-Acyl Taurines were detected in beta cells of Langerhans islets causing insulin secretion results beta cell dysfunction in type 2 diabetes
References Aichler, M., et al.: Cell Metab., 25, 1334-1347 (2017)

Applications Phosmet is used as a pesticide to protect crops and vegetation. Insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sipes, N. et al.: Chem. Res. Tox., 26, 878 (2013); Song, Y. et al.: J. Agri. Food Chem., 6, 2625 (2013); Sinderhauf, K. et al.: J. Label. Compd. Radiopharm., 47, 509 (2004);

Applications Didemethyldiuron acts as a reagent in the synthesis of hydatoin derivatives with anticonvulsant properties. Derivative of Diuron (D494415), a phenyl urea herbicide. Pre-emergent herbicide.
References Mahjabin; S. et al.: Pharm. Chem., 7, 100 (2015); Norsworthy, J., et al.: Weed Technol., 24, 64 (2010), Armenta, S., et al.: Anal. Bioanal., Chem., 397, 297 (2010), Neuwoehner, J., et al.: Aquatic Toxicol., 97, 58 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),

Stability Light Sensitive
Applications (1R)-trans-γ-Cyhalothrin is an isomer of λ-Cyhalothrin (C988980), which is used as an insecticide.
References Bhavani, B., et al.: Pestol., 33, 42 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Schleier, J., et al.: J. Med. Entomol., 46, 693 (2009), Yang, D., et al.: Toxicol. App. Pharmacol., 237, 49 (2009),

Applications N-(4-(4-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)hydrazinecarboxamide is an intermediate in the synthesis of derivatives of Itraconazole (I937500), an orally active antimycotic and antifungal compound.
References Heeres, J., et al.: J. Med. Chem., 27. 894 (1984);

Applications Chlorhexidine Digluconate Impurity N-d4 Hydrochloride, is labelled Chlorhexidine Digluconate Impurity N (C377660), which is a degradation product found in chlorhexidine digluconate solution.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Revelle, L., et. al.: Pharmaceut. Res., 10, 1777 (1993)

Applications 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(4-nitrophenyl)piperazine is an intermediate in the synthesis of derivatives of Itraconazole (I937500), an orally active antimycotic and antifungal compound.
References Heeres, J., et al.: J. Med. Chem., 27, 894 (1984);

Applications (Z)-1,1'-(2-(2,4-Difluorophenyl)prop-1-ene-1,3-diyl)bis(1H-1,2,4-triazole) is an impurity of Fluconazole (F421000), an antifungal.
References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985),

Applications 5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1-​(2,​2-​dimethoxyethyl)​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-2-pyridinecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Cabotegravir-d3 (C050102), which is the labelled form of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)

Applications Hydrobromic acid is a strong acid that is used in conjunction with Phenol (P318005) to carry out rapid cleavage of sulfonamides. Hydrobromic acid is also used as a catalyst to reduce sulfoxides, such as Dimethyl sulfoxide (D479380).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aida, T., et al.: Tetrahedron Lett., 14, 39 (1973); Snyder, H. & Geller, H.: J. Am. Chem. Soc., 74, 4864 (1952)

Applications Asunaprevir is an inhibitor of the viral enzyme serine protease HCV NS3. Also functions as a second generation NS3/4A protease inhibitor used in the treatment of hepatitis C.
References Takehara, T., et al.: Igaku no Ayumi, 255, 1155 92015); Kalaghatgi, P., et al.: PLoS One, 11, 5 (2016)

Applications N-(2-Hydroxyethyl)tetracosanamide acts as a crude oil emulsifier.
References Zhiqiang, J., et al.: Fami Zhu Shen., 5 (2016)

Applications A metabolite of Ofloxacin (O245750).
References Okazaki O., et al.: Xenobiotica, 22, 439 (1992), Murakami, K., et al.: Drugs, 49, 331 (1995),