Eterocicli con azoto (N)

<p>Applications Phenyl (4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamate Hydrochloride is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 4-(6-hydrazinylpyrimidin-4-yl)morpholine (cas# 5767-36-2) is a useful research chemical.<br></p>

<p>Applications 2,2-Dimethylpiperazine is a chemical reagent used in the preparation of non-covalent NAAA inhibitors used as a protective agent for the development of multiple sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Migliore, M. et al.: Angew. Chem. Int. Ed., 55, 11193 (2016);<br></p>

<p>Applications 2-(Difluoromethoxy)pyridin-4-amine (cas# 1211587-46-0) is a useful research chemical.<br></p>

<p>Applications Bimodal effect of the picolinic acid derivatives on the rate of wheat and pea germination.<br>References Hamaker, J., et al.: Science, 141, 363 (1963),<br></p>

<p>Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine is an intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.<br>References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);<br></p>

<p>Applications 4-Bromo-2-(methoxymethyl)pyridine (cas# 864412-04-4) is a useful research chemical.<br></p>

<p>Applications 5-Ethyl-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole-d5 is an isotope labelled impurity of Eletriptan (E505000), a serotonin 5-HTIB/ID receptor agonist and an antimigraine agent.<br>References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998), Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999), Goadsby, P.J., et al.: Neurology, 54, 156 (2000)<br></p>

<p>Applications: 2,7-Dimethyl-[1,4]dioxino[2,3-b:5,6-b']dipyridine is intermediate in the synthesis of compounds used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Applications 3-(PIPERAZIN-1-YL)-1,2-BENZISOXAZOLE (cas# 87691-89-2) is a useful research chemical.<br></p>

<p>Applications Isotope labelled 1-Ethyl-5-hydroxy-2-pyrrolidinone (E919175), an important organic solvent used in varnishing. Industrial solvent.<br>References Koch, H. et al. Arch. Toxicol., 88, 893 (2014); Koslitz, S. et al.: Toxicol. Lett., 231, 142 (2014);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Used in the synthesis of peptides. Contains up to 10% imidazole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pierschbacher, M., et al.: Nature, 309, 30 (1984),<br></p>

<p>Applications Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate-d3 is labelled Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate (P698600) which is a useful synthetic intermediate.<br></p>

<p>Applications 5-pyridin-3-ylfuran-2-carboxylic acid (cas# 56632-46-3) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-cyclopropyl-4-oxazolecarboxylic Acid Ethyl Ester, is a heterocyclic building block used in the chemical synthesis.<br></p>

<p>Applications N-[5-(4-Bromophenyl)-6-[2-(2-pyrimidinyloxy)ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications (2-[(4-Chlorobenzoyl)-(5-trifluoromethylpyridin-2-yl)amino]-ethyl)-trimethyl-ammonium Iodide is a useful synthetic intermediate.<br></p>

<p>Applications 6-chloro[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas# 33050-32-7) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Stability Moisture Sensitive<br>Applications Pentathiodiphosphorus(V) Acid P,P′-Bis(pyridinium betaine) is an thionating agent used in synthetic chemistry.<br>References Bergman, J., et al.: J. Org. Chem., 76, 1546 (2011);<br></p>

<p>Applications 4-Amino-2,2,6,6-tetramethylpiperidine-d17; 1-15N-1-oxyl (CAS# 97461-87-5) is a useful isotopically labeled research compound that is used in various experiments, such as, synthesis of two cysteine-specific spin labels.<br>References Wu,G. J. Label. Compd.Radiopharm., 12,1173-1181,(1995);<br></p>

<p>Applications 2,4-Dinitro-1H-imidazole is a reagent that can be used to synthesize (S)-PA 824 (P122500), which is a novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Applications Urazole derivative.<br></p>

<p>Applications 4-Nitro-1,2,3-triazole is a highly impact sensitive and explosive material.<br>References Politzer, P. et al.: Int. J. Quant. Chem., 61, 389 (1997);<br></p>

<p>Applications 5-(3-fluorophenyl)-4H-1,2,4-triazol-3-amine (cas# 502685-67-8) is a useful research chemical.<br></p>

<p>Applications 5-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications Oxazolidine-4-carboxylic acid hydrochloride (cas# 162285-30-5) is a useful research chemical.<br></p>

<p>Applications tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate (cas# 371775-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-ethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid (cas# 80709-74-6) is a useful research chemical.<br></p>

<p>Applications 5-Chloro-2,3-difluoropyridine is a 2,3,5-trihalopyridine used in the preparation of the herbicides and pesticides such as chodinafop-propargyl.<br>References Chen, Q. et al.: Jin. Huag. Zhong., 35, 35 (2005); Feng, C. et al.: Nonyao, 46, 793 (2007);<br></p>

<p>Applications 4-{[5-(trifluoromethyl)pyridin-2-yl]amino}butanoic acid (cas# 923121-46-4) is a useful research chemical.<br></p>

<p>Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(3,5-Dimethylpyrazol-1-yl)phenylboronic acid, pinacol ester<br></p>

<p>Applications 1-(Formamidomethyl)-1H-benzotriazole is a useful reagent for the synthesis 1-​isocyanomethyl azoles and related compounds.<br>References Saikachi, H., et al.: Chem. Pharm. Bull., 31, 723 (1983)<br></p>

<p>Applications 4-Hydroxythieno[2,3-d]pyrimidine (cas# 14080-50-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-(4’-Benzyloxyphenyl)-2-oxazolidone (cas# 88693-98-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d17 (CAS# 52168-48-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Dimethyl-5-pyrazolone (cas# 2749-59-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-5-bromopyrazine (cas# 59489-71-3) is a compound useful in organic synthesis.<br>References Shi, Z., et al.: J. Med. Chem., 51, 3684 (2008), Onda, K., et al.: Bioorg. Med. Chem., 16, 5452 (2008),<br></p>

<p>Applications 2-(Ethylthio)-1H-benzimidazole is the active substance or the active ingredient in the synthesis of the drug Metaprot. Performs a transplacental function: daily administration of bemithyl (20 mg/kg) from 6 th to 16 th day of pregnancy in female rats led to the decrease in fetal death after the implantation and increased fetal body weight.<br>References Kibal'chich, D. A., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 74, 30 (2011); Bugaeva, L. I., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 70, 40 (2007).<br></p>

<p>Applications An intermediate in the production of Zolpidem metabolites<br>References Klupsch, F., et al.: Chem. Pharm. Bull., 54, 1318 (2006),<br></p>