Eterocicli con azoto (N)

<p>Applications 3-((2S,4S)-4-Mercaptopyrrolidine-2-carboxamido)benzoic Acid Hydrochloride is used as a reactant in the synthesis of a carbapenem antibiotic; Ertapenem Sodium.<br>References Williams, J. Michael, et al.: J. of Org. Chem., 70(19), 7479-7487 (2005)<br></p>

<p>Applications 6-cyclopropyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (cas# 150190-28-6) is a useful research chemical.<br></p>

<p>Applications 2-ETHYNYLPYRIDINE (cas# 1945-84-2) is a useful research chemical.<br></p>

<p>Applications Enalapril Diketopiperazine Acid is a degradation product of Enalapril (E555250).<br>References Bhardwaj, S. et al.: J. Pharmac. Biomed. Anal., 46, 113 (2008);<br></p>

<p>Applications 1-(4-Chlorophenyl)pyrazole-4-carboxylic Acid (cas# 138907-80-9) is a useful research chemical.<br></p>

<p>Applications 3,5-Dimethyl-1-phenyl-1H-pyrazole is a reactant used in the synthesis of hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.<br>References Chenna, V., et. al.: J. Environ. Sci. Heal. A., 49, 641 (2014)<br></p>

<p>Applications Pyridazinone derivatives are useful as intermediates for preparing compounds having excellent herbicidal activity.<br>References Hackler, et al.: J. Agric. Food Chem., 38, 508 (1990)<br></p>

<p>Stability Moisture Sensitive<br>Applications 5-Bromo-pyridine-2-sulfonyl chloride<br></p>

<p>Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 2,5,6-Triamino-4(3H)-pyrimidinone Sulfate is used in the preparation of guanines and other purine derivatives with antiviral activities.<br>References Hemmati, S. et al.: Int. J. Chem. Sci., 2, 9 (2004); Chetsanga, C.J. et al.: Chem.-Biol. inter., 58, 117 (1986);<br></p>

<p>Applications 2-(1-(4-Bromophenyl)-1H-1,2,3-triazol-4-yl)propan-2-ol<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications (3S,​4S)​-​4-​Hydroxy-​3-​pyrrolidinyl Carbamic Acid 1,​1-​Dimethylethyl Ester was used as a chiral pyrrolidine to sense chirality with a liquid crystalline dynamic helical poly(phenylacetylene) bearing ethyl phsophonate pendant groups.<br>References Morimoto, M., et al.: J Polym Sci, 48, 1383 (2010).<br></p>

<p>Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).<br>References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);<br></p>

<p>Applications N-Benzyl-3-hydroxypiperidine has been used as a reactant in the preparation of optically active azidopiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cochi, A., et. al.: Eur. J. Org. Chem., 2012, 2023 (2012)<br></p>

<p>Applications 4-Bromo-1H-1,2,3-triazoleare an important class of organic compounds, playing an important role in modern medicinal chemistry. Compounds with 1,2,3-triazole moieties are known to possess fungicidal, antimicrobial, antidepressant, antibacterial, anti-inflammatory, analgesic and antitumor activities.<br>References Sibgatulin, D. A., et al.: Synthesis, No. 7, 1075 (2010); Karivopalov, V. P., et al.: Chem. Rev. (Engl. Trans), 74, 339 (2005);<br></p>

<p>Applications ethyl (3-bromo-1H-pyrazol-1-yl)acetate (cas# 1427022-51-2) is a useful research chemical.<br></p>

<p>Applications 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors.<br>References Robichaud, J., et al.: J. Med. Chem., 46, 3709 (2003); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 702 (2007)<br></p>

<p>Applications 2,5-Dioxopyrrolidin-1-yl dodecanoate (cas# 14565-47-0) is a useful research chemical.<br></p>

<p>Applications 2-[[6-Amino-5-(4-bromophenyl)-4-pyrimidinyl]oxy]-ethanol is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications 4-(3-Pyridinyl)-3-buten-1-amine is a useful synthetic intermediate.<br></p>

<p>Applications 2-Chloromethyl-3H-benzoimidazole-5-carbonitrile (cas# 150613-50-6) is a useful research chemical.<br></p>

<p>Applications 1,2-Diphenyl-3,5-pyrazolidinedione is a reactant used in organic synthesis such as in the preparation of inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase.<br>References Gilbert, A. et al.: J. Med. Chem., 49, 6027 (2006); Fernandez, Is. et al.: J. Am. Chem. Soc., 131, 11875 (2009);<br></p>

<p>Applications 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.<br>References Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013);<br></p>

<p>Applications Pyrrole-ND (CAS# 10162-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications Fmoc-1-pyrrolidine-3-carboxylic acid<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications [3-(2-Amino-6-methoxy-4-pyrimidinyl)phenyl](3,6-dihydro-4-methyl-1(2H)-pyridinyl)-methanone is a useful chemical for cancer immunotherapy research.<br></p>

<p>Applications 5-(Bromomethyl)-2-fluoropyridine is a useful reagent for preparation of N-Benzylisatinsulfonamides as potent caspase-3 inhibitors.<br>References Chu, W., et al.: J. Med. Chem., 48, 7637 (2005);<br></p>

<p>Applications 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine is an intermediate in the synthesis of Blonanserin (B595850), a 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic.<br>References Oka, T., et al.: Life Sci., 76, 225 (2004), Singh, A., et al.: Int. Med. J., 12, 175 (2005), Ochi, T., et al.: Bioorg. Med. Chem., Lett., 15, 1055 (2005),<br></p>

<p>Applications (7H-Pyrazolo[3,4-b]pyridin-5-yl)methanamine Hydrochloride is a useful research chemical.<br></p>

<p>Applications A substituted pyrimidine used in the study for prediction of relative potency of ketone protease inhibitors using molecular orbital theory.<br>References Chan, A. W. E., et al.: Bioorg. Med. Chem., 4, 1673 (1996),<br></p>

<p>Applications 6-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid (cas# 10176-79-1) is a useful research chemical.<br></p>

<p>Applications 6-ACETYL-PICOLINIC ACID ETHYL ESTER (cas# 114578-70-0) is a useful research chemical.<br></p>

<p>Applications 3-(Triethoxysilyl)propyl 2-((4-amino-5-hydrazinyl-4H-1,2,4-triazol-3-yl)thio)propanoate is a useful reagent for organic reactions.<br></p>

<p>Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.<br>References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);<br></p>

<p>Applications 2,4,6-trimethyl-5-pyrimidinol (cas# 71267-12-4) is a useful research chemical.<br></p>

<p>Applications 5-Ethyl-2-vinylpyridine (cas# 5408-74-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-4-piperidinopyrimidine<br></p>

<p>Applications Ethyl 2-(1H-Pyrrol-2-yl)acetate is an intermediate in the synthesis of rac Ketorolac 6-Benzoyl Isomer (K235620). rac Ketorolac 6-Benzoyl Isomer (Ketorolac EP Impurity C) is an isomeric impurity of Ketorolac (K235620).<br></p>

<p>Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.<br>References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)<br></p>

<p>Stability Light Sensitive<br>Applications A reagent for the determination of aldehydes and other reactive chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),<br></p>

<p>Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 4-Bromo-2-(methoxymethyl)pyridine (cas# 864412-04-4) is a useful research chemical.<br></p>

<p>Applications Ethyl-2-ethoxy-1-[[(2'-cyanobiphenyl-4-yl) methyl] benzimidazole]-7-carboxylate<br></p>

<p>Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.<br>References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);<br></p>

<p>Applications 3-(PIPERAZIN-1-YL)-1,2-BENZISOXAZOLE (cas# 87691-89-2) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-3-methylpicolinic Acid is used to prepare oxazine derivatives as BACE inhibitors useful in treatment of neurological disorders.<br>References Badiger, S., et al.: PCT Int. Appl., WO 2011009943 A1 20110127 (2011); Tintelnot-Blomley, M., et al.: PCT Int. Appl., WO 2011080176 A1 20110707 (2011)<br></p>

<p>Applications Dimethylhydrazone-1-methyl-4-piperidinone is an intermediate in the synthesis of α-Meprodine Hydrochloride (M224950), which is a narcotic analgesic. An analogue of Proline (P755300).<br>References Iorio, M.A., et al.: J. Med. Chem., 20, 309 (1977),<br></p>

<p>Applications 3-FLUOROPYRAZIN-2-AMINE (cas# 1206523-95-6) is a useful research chemical.<br></p>

<p>Applications 6,​8-​Dibromo-​3,​4-​dihydro-​3,​3-​bis(1-​pyrrolidinylmethyl)​-2H-1-benzopyran-4-ol is a useful synthetic reagent.<br></p>